Inotiv的动态

A new publication on #TargetedProteinDegradation by James Gregory, Christopher Hickey, PhD, Juan C. Chavez and Angela Cacace in Cell Press offers insights into potential approaches for #TPD in neurodegenerative diseases. Read the full article to learn more: https://bitly.cx/hUdx #Innovation #Research #Neuroscience

#WorldParkinsonsDay Today, we recognize World Parkinson's Day, a time to raise awareness about Parkinson's disease and support those affected by it. ?? Let's stand together in solidarity, spreading understanding, and advancing research towards a cure.?? Our humanized B6-hSNCA mouse model serves as a valuable tool for PD research, offering insights into disease mechanisms and potential therapies. ?? Leveraging our TurboKnockout technology, we can customize models with specific mutations, supporting diverse experimental needs in pharmacology and PD-related fields. Learn more about this model: https://lnkd.in/gZt7ZNbC #ParkinsonsAwareness #neuroscience #knockout?#bioengineering?#phd?#phdlife?#scienceandtechnology?#research?#researchanddevelopment?#biotech?#biotechnology?#sciencecommunication?#preclinical?#preclinicalresearch?

Missed our webinar? Don’t worry! You can still catch all the breakthroughs in revolutionizing your #neurodegenerative drug discovery and development with our precise, multiplexed #biomarker assays. Watch our on-demand webinar and see how Inoviv is revolutionizing the field with advanced #proteomics solutions. Don’t miss out on this chance to fast-track your research goals. Watch here - https://lnkd.in/eQDGX3MV #Neurodegeneration #Neuroscience #DrugDiscovery

Metformin decelerates aging clock in male monkeys Researchers investigated the geroprotective effects of a 40 months metformin treatmenr in adult male cynomolgus monkeys. The study, publishedbin Cell: https://lnkd.in/eaBJJCH2, involved a multi-omic analysis, including transcriptomics, methylomics, proteomics, and metabolomics, to develop novel monkey aging clocks. Metformin significantly slowed aging indicators, most notably a 6-year regression in brain age. This neuroprotective effect was partially mediated by Nrf2 activation. The findings demonstrate the potential of metformin to systemically reduce biological age in primates, offering promising avenues for pharmaceutical interventions against human aging. #genetics #genomics #aging #longevity #antiaging #precisionmedicine #genomicmedicine #brain #neurology #neuroscience #cognition #omics #multiomics #rna #metabolism #transcriptomics #metabolomics #neurodegeneration #aging #longevity #drugs #drugrepurposing #biomarkers #therapeutics #biotechnology #innovation #research #science #sciencecommunication

in vitro Calcium Imaging can help you understand your compounds' mechanisms of action at the neuronal network level. ? Streamlined Lead Selection: Optimize your lead compounds with a functional assay that rapidly demonstrates their impact on neuronal networks. ? Long-Term Monitoring: Measure neuronal activity over extended periods using e.g. organotypic slice cultures. ? Cell-Type Specific Insights: Utilize genetically encoded dyes for precise, cell-type specific monitoring. ? Versatile Integration: Combine with other techniques like patch-clamp for single-cell calcium transient analysis or viral shRNA expression for targeted gene silencing in organotypic brain slices. Ready to advance your research? We're here to support you! ?? [email protected] to explore how our expertise can enhance your research journey. ?? We look forward to connecting and discussing your project! #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch

A recent 40-month study reveals that metformin prevents brain atrophy and enhances cognitive function in aged male primates. By slowing aging across various tissues, metformin exerts a substantial neuroprotective effect, partially through Nrf2 activation. These findings highlight metformin’s potential in reducing biological age, paving the way for innovative pharmaceutical strategies against human aging. Further research is urgently needed in this area! https://lnkd.in/d-fs2kqV https://lnkd.in/duz2fZNk

As of Mind-2024, Several promising therapies are being developed across various fields of Medicine and Biotechnology. Here are some notable examples: #Geneeditingtherapies #Immunotherapy #RNAbasedtherapied #Regenerative Medicine #Precision Medicine #Digital Therapeutic and Health Technologies #Neuroscience and Brain Health #Antibiotics Alternatives and Antiviral Therapies These therapies represent a blend of innovative technologies, including advanced biological, genetic engineering, and digital health solutions, aimed at addressing unmet medical needs and improving patient outcomes. ongoing clinical trends and research are crucial to further validate their efficacy, safety, and broad applicability in Healthcare.

#EditorsChoice ?? Development of Alzheimer’s Disease Biomarkers: From CSF- to Blood-Based Biomarkers — Mankhong and colleagues. In this paper, the authors aimed to review and discuss different groups of blood-based biomarker candidates for Alzheimer’s disease therapeutics and diagnostics. Full text is available ?? https://lnkd.in/dCb9WX7Y #medicine?#health?#research?#science #neuroscience

Happy to Share! Our newest research publication,"Network Pharmacology-Based Approach to Elucidate the Pharmacologic Mechanisms of Natural Compounds from Dictyostelium discoideum for Alzheimer's Disease Treatment" has just been published! In this study, our research team delve into the potential of secondary metabolites from Dictyostelium discoideum as multi-target treatments for Alzheimer's disease, using advanced network pharmacology methods. Their findings highlight nearly 50 potential targeting genes and multiple signaling pathways, with a particular focus on the neuroinflammatory pathway mediated by COX-2. For those interested in the detailed mechanisms and potential therapeutic effects of these natural compounds, check out our full article. We're happy to continue this line of research and contribute to the development of more effective AD treatments. Click the below link for the significant step towards understanding how natural compounds can be used more effectively in combating Alzheimer's disease. https://lnkd.in/dBZ-9eJR Authors: Dr. Mukul Jain, Nil Patil, Rupal Dhariwal, Lee Seong Wei, and Airfullah Mohammed Parul University Mukul Jain, PhD Patil Nil ?? Rupal Dhariwal #AlzheimersResearch #Pharmacology #Neuroscience #Publication #ResearchImpact #Cellpress #Heliyon #ComputationBiology #NetworkPharmacology #Neuro #NeuroDegeneration

Open Science:?Fueling the Fight Against Neurodegenerative Diseases Open science holds the key to precision medicine for neurodegenerative diseases like Alzheimer's. Its power lies in large, diverse, and shared datasets that fuel target discovery, biomarker development, and understanding disease complexities. Challenges like data accessibility and diverse representation can be overcome through collaboration, federated analysis, and knowledge graphs. By fostering transparency and inclusivity, open science can accelerate research, improve drug development, and ultimately benefit patients with these devastating illnesses. The commentary was published in Nat Rev Drug Discovery: https://lnkd.in/e-dCF-xM. #genetics #genomics #precisionmedicine #genomicmedicine #brain #neurology #neurodegeneration #neuroscience #alzheimers #parkinsons #aging #longevity #therapeutics #biomarkers #biotechnology #pharma #university #clinicalresearch #omics #multiomics #openscience #collaboration #publichealth #drugdiscovery #drugdevelopment #innovation #research #science #sciencecommunication