??????? Part 19 of 49 - Video Presentations of the "1st Conference on Integrating Early Detection of Heart and Lung Disease through Low-Dose CT": Day 1 Session 3: Sex and Race Differences in Visceral Fat and CVD. Dr. Susan K. Fried, PhD, highlights how sex and race differences in visceral fat impact cardiovascular disease and diabetes risk. https://wix.to/bVtplZn Hosted by the International Early Lung Cancer Action Program (I-ELCAP). We want to thank our distinguished speakers, including Dr. Samuel M. Aguayo, MD, Dr. Nasser Altorki, MD, Dr. Amir Ahmadi, MD, Ricardo Avila, MS, Dr. Mary Beth Beasley, MD, Vickie Beckler, MBA, RN, Peter Bernholt, Dr. Andrea Branch, PhD, Dr. Matthew Cham, MD, Dr. Joelle Thirsk Fathi DNP, RN, ARNP, CTTS, FAANP, FAAN, Dr. Zahi Fayad, Dr. raja flores MD, Dr. Susan K. Fried, Dr. Valentin Fuster, MD, PhD, Dr. Elizabeth Garner, MD, MPH, Dr. Ilya Gipp MD, PhD, Dr. Yongfeng Gao, PhD, Dr. Lee Goldsmith, MD, Dr. Frederic Grannis Jr, MD, Catharine Grimes, MBA, Dr. Louis Gros, MD, Dr. Timothy Harkin, MD, Dr. Robert A. Harrington MD, Dr. Sebron Harrison, MD, Dr. Rob Headrick MD MBA, Cheryl Healton, DrPH, Dr. Claudia Henschke, PhD, MD, Dr. Fred Hirsch, MD, PhD, Dr. Mingqian Huang, MD, Dr. Ella A. Kazerooni, MD, MS, Dr. Karen Kelly, MD, Dr. Paul Lee, MD, Dr. David Maron, MD, Dr. Steven Markowitz, MD, DrPH, Dr. Glenn Martin, MD, Dr. Michael V. McConnell, MD, MSEE, Anita McGlothlin, Dr. Jeffrey Mechanick, MD, Dr. Roxana Mehran, MD, Dr. Mark Metersky, MD, Dr. Jim Mulshine, MD, Dr. Morteza Naghavi, M.D., Dr. Jagat Narula MD PhD, Dr. Khurram Nasir, MD MPH MSc, Dr. Maria Padilla, MD, Dr. Sean Pinney, MD, Dr. Bruce Pyenson, FSA, MAAA, Juan Carlos Ramirez-Giraldo, PhD, Dr. Jamal Rana MD FACC, Dr. Vivek Reddy, MD, Anthony Reeves, PhD, Dr. Albert Rizzo, MD, Lori Sakoda, PhD, MPH, Dr. Robert Samstein, MD, PhD, Dr. Victoria Schneider, MD, Dr. Dorith Shaham, MD, Dr. Samin K. Sharma, MD, Dr. Joseph Shemesh, MD, Dr. Samir Shah, MD, Robert Smith, PhD, Dr. Rozemarijn Vliegenthart, MD, PhD, Dr. Andrea Wolf, MD, MPH, Dr. Nathan Wong, MD, PhD, Dr. David Yankelevitz, MD, Dr. Rowena Yip, PhD, MPH, Chenyu Zhang, MS, Dr. Javier J Z., MD, and many more world leaders in cardiovascular disease and lung cancer screening for making the 1st Conference on Integrating Early Detection of Heart and Lung Disease through Low-Dose CT possible. Special thanks to our sponsors GE HealthCare led by Roland Dias, Ilya Gipp MD, PhD, Siemens Healthineer led by Sebastian Schmidt, and other leading medical companies in CT imaging and AI. #CardioTwitter #AutoChamber #AICVD #AICAC #CCTA #CAC #CACscan #CACscore #calciumscore #calcium_score #coronary_calcium_score #coronary_calcium #CAC_scan #CAC_score #HeartFlow #Cleerlyhealth #Cardiology #AIinHealthcare #heartfailure #Afib #FDAbreakthrough #heartdisease #heartdiseaseprevention #lungcancer #lungcancerprevention #LDCTscreening #LDCT_screening #shapesociety SHAPE Society (Society for Heart Attack Prevention and Eradication)
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Great talk by Dr. Susan Fried and Dr. Jeffery Mechanic showing that pathologic adepocity particularly intramuscular is associated with CVD and mortality. A recent manuscript on this topic has just been submitted for publication by the AI-CVD coauthors showing the clinical significance of AI detected myosteatosis in calcium scans.
??????? Part 19 of 49 - Video Presentations of the "1st Conference on Integrating Early Detection of Heart and Lung Disease through Low-Dose CT": Day 1 Session 3: Sex and Race Differences in Visceral Fat and CVD. Dr. Susan K. Fried, PhD, highlights how sex and race differences in visceral fat impact cardiovascular disease and diabetes risk. https://wix.to/bVtplZn Hosted by the International Early Lung Cancer Action Program (I-ELCAP). We want to thank our distinguished speakers, including Dr. Samuel M. Aguayo, MD, Dr. Nasser Altorki, MD, Dr. Amir Ahmadi, MD, Ricardo Avila, MS, Dr. Mary Beth Beasley, MD, Vickie Beckler, MBA, RN, Peter Bernholt, Dr. Andrea Branch, PhD, Dr. Matthew Cham, MD, Dr. Joelle Thirsk Fathi DNP, RN, ARNP, CTTS, FAANP, FAAN, Dr. Zahi Fayad, Dr. raja flores MD, Dr. Susan K. Fried, Dr. Valentin Fuster, MD, PhD, Dr. Elizabeth Garner, MD, MPH, Dr. Ilya Gipp MD, PhD, Dr. Yongfeng Gao, PhD, Dr. Lee Goldsmith, MD, Dr. Frederic Grannis Jr, MD, Catharine Grimes, MBA, Dr. Louis Gros, MD, Dr. Timothy Harkin, MD, Dr. Robert A. Harrington MD, Dr. Sebron Harrison, MD, Dr. Rob Headrick MD MBA, Cheryl Healton, DrPH, Dr. Claudia Henschke, PhD, MD, Dr. Fred Hirsch, MD, PhD, Dr. Mingqian Huang, MD, Dr. Ella A. Kazerooni, MD, MS, Dr. Karen Kelly, MD, Dr. Paul Lee, MD, Dr. David Maron, MD, Dr. Steven Markowitz, MD, DrPH, Dr. Glenn Martin, MD, Dr. Michael V. McConnell, MD, MSEE, Anita McGlothlin, Dr. Jeffrey Mechanick, MD, Dr. Roxana Mehran, MD, Dr. Mark Metersky, MD, Dr. Jim Mulshine, MD, Dr. Morteza Naghavi, M.D., Dr. Jagat Narula MD PhD, Dr. Khurram Nasir, MD MPH MSc, Dr. Maria Padilla, MD, Dr. Sean Pinney, MD, Dr. Bruce Pyenson, FSA, MAAA, Juan Carlos Ramirez-Giraldo, PhD, Dr. Jamal Rana MD FACC, Dr. Vivek Reddy, MD, Anthony Reeves, PhD, Dr. Albert Rizzo, MD, Lori Sakoda, PhD, MPH, Dr. Robert Samstein, MD, PhD, Dr. Victoria Schneider, MD, Dr. Dorith Shaham, MD, Dr. Samin K. Sharma, MD, Dr. Joseph Shemesh, MD, Dr. Samir Shah, MD, Robert Smith, PhD, Dr. Rozemarijn Vliegenthart, MD, PhD, Dr. Andrea Wolf, MD, MPH, Dr. Nathan Wong, MD, PhD, Dr. David Yankelevitz, MD, Dr. Rowena Yip, PhD, MPH, Chenyu Zhang, MS, Dr. Javier J Z., MD, and many more world leaders in cardiovascular disease and lung cancer screening for making the 1st Conference on Integrating Early Detection of Heart and Lung Disease through Low-Dose CT possible. Special thanks to our sponsors GE HealthCare led by Roland Dias, Ilya Gipp MD, PhD, Siemens Healthineer led by Sebastian Schmidt, and other leading medical companies in CT imaging and AI. #CardioTwitter #AutoChamber #AICVD #AICAC #CCTA #CAC #CACscan #CACscore #calciumscore #calcium_score #coronary_calcium_score #coronary_calcium #CAC_scan #CAC_score #HeartFlow #Cleerlyhealth #Cardiology #AIinHealthcare #heartfailure #Afib #FDAbreakthrough #heartdisease #heartdiseaseprevention #lungcancer #lungcancerprevention #LDCTscreening #LDCT_screening #shapesociety SHAPE Society (Society for Heart Attack Prevention and Eradication)
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Advancing Early Detection: Insights from the "1st Conference on Integrating Early Detection of Heart & Lung Disease" Part 15 of 49 features a key panel from Day 1, Session 2, where experts in lung cancer screening, interstitial lung diseases, and pulmonary medicine highlighted the impact of low-dose CT in detecting COPD, emphysema, and bronchiectasis early. Watch here: https://wix.to/31Jz02w #COPD #Emphysema #EarlyDetection #LungScreening #LowDoseCT
??????? Part 15 of 49 - Video Presentations of the "1st Conference on Integrating Early Detection of Heart and Lung Disease through Low-Dose CT": Day 1 Session 2: Panel Discussions. Experts in pulmonary medicine discuss the need for early detection of lung diseases, the use of low-dose CT scans, and the role of pulmonologists in patient care. https://wix.to/31Jz02w Hosted by the International Early Lung Cancer Action Program (I-ELCAP). We want to thank our distinguished speakers, including Dr. Samuel M. Aguayo, MD, Dr. Nasser Altorki, MD, Dr. Amir Ahmadi, MD, Ricardo Avila, MS, Dr. Mary Beth Beasley, MD, Vickie Beckler, MBA, RN, Peter Bernholt, Dr. Andrea Branch, PhD, Dr. Matthew Cham, MD, Dr. Joelle Thirsk Fathi DNP, RN, ARNP, CTTS, FAANP, FAAN, Dr. Zahi Fayad, Dr. raja flores MD, Dr. Susan K. Fried, Dr. Valentin Fuster, MD, PhD, Dr. Elizabeth Garner, MD, MPH, Dr. Ilya Gipp MD, PhD, Dr. Yongfeng Gao, PhD, Dr. Lee Goldsmith, MD, Dr. Frederic Grannis Jr, MD, Catharine Grimes, MBA, Dr. Louis Gros, MD, Dr. Timothy Harkin, MD, Dr. Robert A. Harrington MD, Dr. Sebron Harrison, MD, Dr. Rob Headrick MD MBA, Cheryl Healton, DrPH, Dr. Claudia Henschke, PhD, MD, Dr. Fred Hirsch, MD, PhD, Dr. Mingqian Huang, MD, Dr. Ella A. Kazerooni, MD, MS, Dr. Karen Kelly, MD, Dr. Paul Lee, MD, Dr. David Maron, MD, Dr. Steven Markowitz, MD, DrPH, Dr. Glenn Martin, MD, Dr. Michael V. McConnell, MD, MSEE, Anita McGlothlin, Dr. Jeffrey Mechanick, MD, Dr. Roxana Mehran, MD, Dr. Mark Metersky, MD, Dr. Jim Mulshine, MD, Dr. Morteza Naghavi, M.D., Dr. Jagat Narula MD PhD, Dr. Khurram Nasir, MD MPH MSc, Dr. Maria Padilla, MD, Dr. Sean Pinney, MD, Dr. Bruce Pyenson, FSA, MAAA, Juan Carlos Ramirez-Giraldo, PhD, Dr. Jamal Rana MD FACC, Dr. Vivek Reddy, MD, Anthony Reeves, PhD, Dr. Albert Rizzo, MD, Lori Sakoda, PhD, MPH, Dr. Robert Samstein, MD, PhD, Dr. Victoria Schneider, MD, Dr. Dorith Shaham, MD, Dr. Samin K. Sharma, MD, Dr. Joseph Shemesh, MD, Dr. Samir Shah, MD, Robert Smith, PhD, Dr. Rozemarijn Vliegenthart, MD, PhD, Dr. Andrea Wolf, MD, MPH, Dr. Nathan Wong, MD, PhD, Dr. David Yankelevitz, MD, Dr. Rowena Yip, PhD, MPH, Chenyu Zhang, MS, Dr. Javier J Z., MD, and many more world leaders in cardiovascular disease and lung cancer screening for making the 1st Conference on Integrating Early Detection of Heart and Lung Disease through Low-Dose CT possible. Special thanks to our sponsors GE HealthCare led by Roland Dias, Ilya Gipp MD, PhD, Siemens Healthineer led by Sebastian Schmidt, and other leading medical companies in CT imaging and AI. #CardioTwitter #AutoChamber #AICVD #AICAC #CCTA #CAC #CACscan #CACscore #calciumscore #calcium_score #coronary_calcium_score #coronary_calcium #CAC_scan #CAC_score #HeartFlow #Cleerlyhealth #Cardiology #AIinHealthcare #heartfailure #Afib #FDAbreakthrough #heartdisease #heartdiseaseprevention #lungcancer #lungcancerprevention #LDCTscreening #LDCT_screening #shapesociety SHAPE Society (Society for Heart Attack Prevention and Eradication)
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?? Important Findings for Childhood Cancer Survivors’ Long-Term Health ?? A groundbreaking study has shed light on the cardiac, vascular, and metabolic changes in young adults who survived childhood cancer. Conducted by a team of researchers including Olof Broberg, Ingrid ?ra, Thomas Wiebe, Constance Weismann, Petru Liuba, the study found significant differences in cardiovascular health markers between survivors and healthy controls. ?? Utilizing advanced ultrasonography, researchers discovered that childhood cancer survivors, particularly those exposed to higher doses of anthracyclines, exhibit critical changes in carotid distensibility and endothelial function. These survivors also showed higher levels of atherogenic apolipoproteins and lipids, factors contributing to an increased risk of cardiovascular diseases (CVD) later in life. ?? The findings, published in a leading medical journal, underscore the necessity of regular cardiometabolic monitoring for these individuals, even if they are asymptomatic. https://lnkd.in/dbCYHb-P Earn 1.0 #CME by learning more about this vital research and its implications. #Cardiology #CancerSurvivors #MedicalResearch #HealthcareInnovation #PhysicianInsights
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?? New Insights into Retinal Disease Biomarkers!? The National Eye Institute (NEI) has uncovered a groundbreaking dual role for annexin-V, a key biomarker used to track retinal cell degeneration. Traditionally linked to apoptosis, annexin-V has now been found to bind with immune cells, suggesting its potential as a marker for ocular inflammation. ?? Key Findings: ? Annexin-V binds to both apoptotic cells and immune cells. ? Opens new possibilities for monitoring neuroinflammation in conditions like AMD and retinitis pigmentosa. ? Challenges existing interpretations of DARC imaging, a critical technique for retinal research. This discovery could refine retinal disease diagnostics and pave the way for innovative treatments. ?? Learn more about this exciting research here: https://lnkd.in/dHutE_U9 #Diagnostics #ScientificResearch #EyeDisease #Innovation #RetinalHealth
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Thyroid Cancer A Review JAMA. 2024;331(5):425-435. doi:10.1001/jama.2023.26348 Abstract Importance Approximately 43?720 new cases of thyroid carcinoma are expected to be diagnosed in 2023 in the US. Five-year relative survival is approximately 98.5%. This review summarizes current evidence regarding pathophysiology, diagnosis, and management of early-stage and advanced thyroid cancer. Observations Papillary thyroid cancer accounts for approximately 84% of all thyroid cancers. Papillary, follicular (≈4%), and oncocytic (≈2%) forms arise from thyroid follicular cells and are termed well-differentiated thyroid cancer. Aggressive forms of follicular cell-derived thyroid cancer are poorly differentiated thyroid cancer (≈5%) and anaplastic thyroid cancer (≈1%). Medullary thyroid cancer (≈4%) arises from parafollicular C cells. Most cases of well-differentiated thyroid cancer are asymptomatic and detected during physical examination or incidentally found on diagnostic imaging studies. For microcarcinomas (≤1 cm), observation without surgical resection can be considered. For tumors larger than 1 cm with or without lymph node metastases, surgery with or without radioactive iodine is curative in most cases. Surgical resection is the preferred approach for patients with recurrent locoregional disease. For metastatic disease, surgical resection or stereotactic body irradiation is favored over systemic therapy (eg, lenvatinib, dabrafenib). Antiangiogenic multikinase inhibitors (eg, sorafenib, lenvatinib, cabozantinib) are approved for thyroid cancer that does not respond to radioactive iodine, with response rates 12% to 65%. Targeted therapies such as dabrafenib and selpercatinib are directed to genetic mutations (BRAF, RET, NTRK, MEK) that give rise to thyroid cancer and are used in patients with advanced thyroid carcinoma. Conclusions Approximately 44?000 new cases of thyroid cancer are diagnosed each year in the US, with a 5-year relative survival of 98.5%. Surgery is curative in most cases of well-differentiated thyroid cancer. Radioactive iodine treatment after surgery improves overall survival in patients at high risk of recurrence. Antiangiogenic multikinase inhibitors and targeted therapies to genetic mutations that give rise to thyroid cancer are increasingly used in the treatment of metastatic disease. https://lnkd.in/gwzFk_Wj
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?? Exciting News in Cardiac Immunology!?? ?? Kudos to Elisa Martini, the first author, and the outstanding PIs, Gianluigi Condorelli and Marinos Kallikourdis, from Humanitas Research Hospital, on their groundbreaking publication in Circulation Research. ??This research unveils how pressure overload-induced heart failure partially fulfills criteria for autoimmune disease. The study identified novel cardiac self-antigens capable of triggering cardiac dysfunction. Even more exciting, they developed a tolerizing vaccine using these antigens, which reduced disease severity in mouse models through the induction of effector regulatory T cells. ?? Heart failure remains a significant global health burden, affecting over 64 million people worldwide. This work not only deepens our understanding of the autoimmune components of heart failure but also opens the door for innovative, antigen-specific therapies to potentially prevent or mitigate this devastating condition. ?? Furthermore, it is worth to mention that Extend | the National Technology Transfer Biotech Hub, has invested in and is actively supporting this project. Backed by CDP Venture Capital SGR, Evotec, and Angelini Ventures, Extend fosters the translation of Italian research into clinical applications, bridging academia and industry to advance groundbreaking therapies. ?? Huge congratulations to all the authors for this remarkable achievement: Elisa Martini, Marco Cremonesi, Arianna Felicetta, Simone Serio, Simone Puccio, Erica Pelamatti, Jasper J.P. van Beek, Vasiliki Papadopoulou, Chiara Catalano, Francesca Fanuele, Desirée Giuliano, Gianluca Basso, Cecilia Assunta Bonfiglio, Cristina Panico, Marco Vacchiano, Pierluigi Carullo, Papa Laura, Carla D’Andrea, Naz Tuzger, Sergio Marchini, Paola Magistroni, Silvia Deaglio, Prof. Antonio Amoroso, Enrico Lugli, Gianluigi Condorelli, Marinos Kallikourdis A milestone worth celebrating and a step closer to innovative solutions in heart failure treatment! ??
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Promising research in Nature CD45-PET: a non-invasive tool to image inflammation Inflammation happens in a range of diseases - autoimmunity, aging, cancer. In this study authors used CD45 (which is expressed only by immune cells and by broadly most immune cell subtypes) as a marker of inflammation combined with positron emission tomography (PET). CD45-PET imaging demonstrated exceptional sensitivity and clarity in detecting inflammation across diverse preclinical models, surpassing 18F-FDG-PET in accurately reflecting disease severity in lung and bowel diseases. A human CD45-PET was also developed for clinical translation. CD45-PET, once clinically translated, could reliably detect inflammation across various conditions, potentially affecting the diagnosis, monitoring and treatmentof inflammatory diseases. https://lnkd.in/d5S5Vf9r #inflammation #pediatricrheumatology #immunemediateddiseases
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Rising Rates of Early-Onset Colorectal Cancer: A Call to Action This recent article from the American College of Surgeons Bulletin sheds light on a troubling trend: the dramatic increase in early-onset colorectal cancer among younger generations, including Millennials and Gen Z. Despite advancements in screening and prevention, the number of cases in people under 50 continues to rise. Key facts: ? Many young patients present with no obvious risk factors like obesity or family history. ? Lifestyle and diet are potential contributors, but the driving causes remain unclear. ? This issue has gained attention, partly due to high-profile cases such as Chadwick Boseman’s tragic death. Experts like Dr. Steven Wexner emphasize the urgent need for more research to uncover the underlying causes and improve early detection. As clinicians, researchers, and advocates, we must work to address this growing health crisis. Read the full article below American College of Surgeons The American Society of Colon and Rectal Surgeons American Society of Clinical Oncology (ASCO)
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Medical Director/Senior Medical Science Liaison, Board Certified Family Nurse Practitioner specializing in Gastroenterology
The Journal of the National Cancer Institute just published an article regarding the racial disparities in colorectal cancer incidence and mortality between Black and White Americans and how they relate to surveillance colonoscopies. The results speak loudly to me both as a healthcare provider and as a medical science liaison. ??? The article, titled “Impact of racial disparities in follow-up and quality of colonoscopy on colorectal cancer outcomes” (linked below), found that eliminating disparities between Black and White patients for follow-up colonoscopy rates and quality of colonoscopy screening would result in a 14.6% reduction in colorectal cancer incidence, an 18.7% reduction in colorectal cancer mortality and a 7.1% improvement in life-years gained for Black patients. ?? As a GI nurse practitioner ????, studies like this highlight the importance of taking intentional steps to ensure adherence to recommended surveillance colonoscopies for Black patients above and beyond the standard methods used for patient recalls. As a medical science liaison, it is a call to action to focus medical device innovation on eliminating disparities such as these and to have open conversations with physicians about how we can work together to ensure health equality for all patients. ?? Being aware of these statistics isn’t enough, it is our responsibility in all sectors of healthcare to take action and bring measurable change to improve patient outcomes. I’m thankful to have opportunities in both direct and indirect patient care to help facilitate change and can’t wait to see what the future holds for eliminating healthcare disparities, especially as AI in GI continues to progress. ?? #colorectalcancer #healthdisparities #nationalcancerinstitute #aiingi #artificialintelligence
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LET'S EAT GRANDMA British Medical Journal retracts and replaces article on unexpected weight loss as a sign of cancer ? The retracted paper, "Prioritising primary care patients with unexpected weight loss for cancer investigation: diagnostic accuracy study, https://lnkd.in/eHG5k4-T" appeared Aug. 13, 2020. The researchers, led by Brian D. Nicholson used electronic health records data to look for people diagnosed with cancer within six months after a recording of unexpected weight loss. ? The retraction notice https://lnkd.in/e2zhYX5U, published October 16, stated the authors and journal agreed to retract the flawed paper, and linked to the updated https://lnkd.in/ehegqSma version. The original study included nearly 64,000 patients with unexpected weight loss recorded in their medical records between 2000-2012, of which 1.4% ended up receiving a cancer diagnosis within six months. In the update, the authors analyzed records from about 326,000 patients with unexpected weight loss between 2000-2019. This time, 4.8% had received a cancer diagnosis half a year later. Subscribe to the Telegram channel (https://lnkd.in/eqdRAdUU) and Youtube (https://lnkd.in/e-E6STv6), visit the News (https://entc.com.ua/) and the Clubscience (https://lnkd.in/eNUgQ8KM) in order not to miss the most important! #article #research #publication #retraction #author #editor #journal #BMJ #retractionwatch #technologycenter
