Hamburg Brain School的动态

Meet Dr. Raymond Colello, #AUCMed Professor of Physiology and Neuroscience, whose research is shaping the future of helmet safety in the NFL and inspiring the next generation of doctors. Read more about his story here.

Multi-Site Research Collaboration - Concussion Assessment, Research and Education/Service Academy Long Term Observation Study Integration - The CARE/SALTOS Integrated (CSI) Study, funded by CDMRP, is a public-private partnership designed to address key knowledge gaps around clinical and neurobiological recovery, brain structure and function and factors predicting outcomes in Military Service Academy graduates and the National Collegiate Athletic Association (NCAA) student-athletes. The CARE data collected to date represents the most diverse concussion data of its type ever collected and allows for analysis of groups often neglected in medical literature. The CARE SALTOS study will continue to be overseen by the NCAA/DoD Grand Alliance to yield detailed, longitudinal follow-up evaluations of service members to address critical questions surrounding long-term effects of mTBI and/or head impact exposure on warfighter brain health. Study sites are WRNMMC, USUHS, Fort Cavazos, Fort Liberty and Joint Base Lewis-McChord Traumatic Brain Injury.??

Researchers at the University Medical Center of Hamburg-Eppendorf have published a paper in Neuron, detailing their recent study on the prefrontal cortex in mice. The paper explores the changes that occur in this crucial brain region during adolescence and outlines the patterns of re-organization associated with the regulation of executive functions, such as planning, decision-making, and social behavior modulation. The study provides valuable insights into the development of the prefrontal cortex during adolescence and could help us better understand how to support healthy brain development in humans. Check out the full paper here: https://lnkd.in/dmfavsNX

I am thrilled to announce the publication of my latest review paper titled "Correlation between cognitive changes and neuroradiological changes over time in multiple sclerosis: a systematic review and meta-analysis" ?? You can access the full paper here: https://lnkd.in/euDJciHZ Many studies have looked at how brain imaging relates to cognitive abilities in multiple sclerosis (MS), but not many have focused on changes over time. We don't fully understand how cognitive changes connect with brain changes in MS. This study reviews all research that has examined the link between MRI changes and cognitive changes over at least one year. This systematic review found a significant link between cognitive changes, especially in SDMT/PASAT and verbal fluency, and changes in T2LV and brain atrophy in people with MS. However, the results should be viewed with caution due to limited high-quality research, small sample sizes, and differences in study methods.

#award #duchenne #corticosteroids #vamorolone #brain #MRI #congnition #behavior ? Dr. Rosanne Govaarts, a postdoctoral researcher at LUMC, has been awarded -as one of the seven talented researchers- the Duchenne Parent Project Grant to study the impact of chronic corticosteroid treatment on brain development in Duchenne muscular dystrophy (DMD). Corticosteroids are standard treatments that help delay physical decline. However they have significant side effects, including weight gain and behavioral changes. Recent MRI studies indicate that boys with DMD on daily deflazacort have reduced grey matter volume compared to those on intermittent prednisone, raising questions about the effects on brain phenotypes in Duchenne. This study will investigate how different corticosteroid regimens impact brain structure and function by comparing MRI scans and cognitive assessments among boys on daily vamorolone, intermittent prednisone, and daily deflazacort. Collaborating with the UZ Leuven and the John Walton Muscular Dystrophy Research Centre @ Newcastle University, this research aims to clarify the effects of vamorolone on brain morphology, which could ultimately influence the choice of type of corticosteroid in DMD care. Congratulations Rosanne, on your work in this crucial area of research!

At #SfN24? TODAY, Day 1, from 1-5pm, DON'T MISS the #HofLab's Dr. Carmen Freire-Cobo as she presents "Curcumin effects on ultrastructural changes in synapsis & #Mitochondria in middle-aged rhesus monkeys". Elucidating the impact of aging on the structure and function of neurons is key to understand the mechanisms underlying synaptic dysfunction and ensuing susceptibility to age-related cognitive decline. The role of structural alterations in dorsolateral prefrontal cortex (DLPFC) pyramidal neurons affecting synaptic function has been extensively addressed in cognitive aging studies, although until recently, focusing mainly on aged individuals. New evidence shows that age-related changes in cognition can occur as early as the 4th and 5th decades. In addition, an increasing body of work focuses on the role of #Inflammation and increased oxidative stress during #Aging. The Hof Lab's group previously showed that curcumin, a #Polyphenol component of turmeric with #Antioxidant and anti-inflammatory properties, delays cognitive decline in middle-aged (MA) macaques, as an early intervention. JOIN the #FBIatSfN and Dr. Freire-Cobo to LEARN MORE about her latest work!? Abstract ?? https://lnkd.in/e6VhqbaP #FriedmanBrainInstitute #NashNeuroscience Icahn School of Medicine at Mount Sinai The Mount Sinai Hospital Graduate School of Biomedical Sciences at the Icahn School of Medicine Patrick Hof Carmen Freire, PharmD, PhD Society for Neuroscience

?? *READ ABSTRACT BELOW:* Keywords: Cardiac resynchronization therapy; Electrocardiogram; Functional principal component decomposition; Heart failure; Machine learning; Magnetic resonance imaging. Cardiac resynchronization therapy (CRT) can lead to marked symptom reduction and improved survival in selected patients with heart failure with reduced ejection fraction (HFrEF); however, many candidates for CRT based on clinical guidelines do not have a favorable response. A better way to identify patients expected to benefit from CRT that applies machine learning to accessible and cost-effective diagnostic tools such as the 12-lead electrocardiogram (ECG) could have a major impact on clinical care in HFrEF by helping providers personalize treatment strategies and avoid delays in initiation of other potentially beneficial treatments. This study addresses this need by demonstrating that a novel approach to ECG waveform analysis using functional principal component decomposition (FPCD) performs better than measures that require manual ECG analysis with the human eye and also at least as well as a previously validated but more expensive approach based on cardiac magnetic resonance (CMR). Analyses are based on five-fold cross validation of areas under the curve (AUCs) for CRT response and survival time after the CRT implant using Cox proportional hazards regression with stratification of groups using a Gaussian mixture model approach. Furthermore, FPCD and CMR predictors are shown to be independent, which demonstrates that the FPCD electrical findings and the CMR mechanical findings together provide a synergistic model for response and survival after CRT. In summary, this study provides a highly effective approach to prognostication after CRT in HFrEF using an accessible and inexpensive diagnostic test with a major expected impact on personalization of therapies. Bivona DJ, Comput Biol Med. 2024 Aug;178:108627. doi: 10.1016/j.compbiomed.2024.108627. Epub 2024 May 22. PMID: 38850959; PMCID: PMC11265973. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Our review paper on sensory integration for neuroprostheses is finally out! This work was spearheaded by super talented Ph.D. candidate Keqin (Catherine) Ding at The Johns Hopkins University's Dr. Nitish Thakor's lab and with the collaboration of Dr. Gordon Cheng and Natalia Paredes-Acuna from the Technical University of Munich. This review paper reviews the most recent research on the efforts to create sensory integration in neuroprostheses and offers a better perspective for understanding this mechanism. First, we focus on how studies used stimulation-elicited percepts to maximize and improve the reliability of somatosensory information. Second, we reviewed studies that have suggested multi-sensory integration in prostheses and shown evidence of cognitive benefits in the form of agency and ownership of the prosthesis. We then reviewed the theoretical models and neuroscience evidence of sensory integration in the context of prostheses. Lastly, we discuss some ongoing research and challenges to achieving and understanding sensory integration in neuroprostheses. You can read the paper here: https://lnkd.in/eDeSMSJP #neuroprosthetics #BMI #BCI #sensoryfeedback #neuralprosthetics

Discover the fascinating journey of the brain throughout life! Our latest research delves into lifelong brain morphometric dynamics. Uncover the secrets of healthy neurodevelopment and aging @Biomed_MDPI @MDPIOpenAccess #Neuroscience

?? Exploring New Frontiers in Stroke Rehabilitation: Medical School Faculty Study on Locomotor Recovery In a recent study, Medical School faculty, Prof Avgis Hadjipapas, and Dr Charalambos C. Charalambous, a former postdoctoral fellow at UNIC and now a faculty member at Duke University School of Medicine, have made progress in this area. Their research, published in Experimental Brain Research, investigates the role of supraspinal inputs via pyramidal and extrapyramidal tracts in the function of calf muscles during walking in chronic stroke patients. ?? Read More: https://lnkd.in/d_hzwbnC