Gnome Sciences的动态

???????????????????? ?????????????? ???????? ?? ?????????????? ???????? ???? ???????????????????? ?????? ?????????????????? ???? ?????? ??????????????????. One common degradation pathway involves the fragmentation of large RNA molecules into smaller fragments. In this application note, we investigate the difference in ?????????????????????? of 1,000 and 4,000 ? ????????-?? ?????????????? with two model mRNA compounds, Cas9 mRNA and EPO mRNA. ???? ????-???? ???????????? ?????? ?????????????????? ?????? ???????????? ?????????????????????????? ???? ???????? ??????????????. Good elution and separation for mRNA samples of various lengths were obtained in a short run time and with limited carryover. ?????? ????????-?? ?????????????????? ?????????????????? ???????? ???? ?????????? ????????????, providing the best pore size for the mRNA under investigation. More specifically, using the Agilent Technologies PLRP-S 4000 ? column, ???????? ???????????????????? ?????? ???????? ???????????????????? for both native and heated sample were easily obtained. ? Arnaud Delobel, Claire Butré, Jennifer Bouchenna, Damien Mouvet (QUALITY ASSISTANCE S.A.) Andrew Coffey, Andrea Angelo P. Tripodi (Agilent Technologies) ?? Download and share this application now ??

Scientific publications require creation of hypotheses, experimental and assay development, careful analysis of results to ensure reproducibility, and trusted reagents. Our catalog of buffers are?tested and trusted. See the number of publications that cite our products in the chart below and check out some recent peer reviewed publications cited with our products: https://lnkd.in/eZg5fXtR #custombuffers #customreagents #lifesciencebuffers #lifesciencereagents #diagnostics #biosimilar #bioprocessing #assaydevelopment?

Direct detection assays are a cost-saving innovation that help to improve resource efficiency by eliminating the nucleotide extraction step. However, clinical samples contain inhibitors that can significantly reduce assay sensitivity and performance, especially in direct qPCR/RT-qPCR assays. Meridian’s inhibitor-tolerant, specimen-specific master mixes enable direct detection without comprising performance. Our master mixes have been optimized for highly sensitive amplification on crude samples such as blood, serum, saliva, urine and stool and offer significant benefits, including reduced (1) hands-on-time, (2) turn-around-time (TAT) and (3) cost. Click here to learn more: https://lnkd.in/gnF6BVvM #moleculardiagnostics #sustainability #assayefficiency #innovation

Why Affinity Selection Mass Spectrometry for your Molecular Glue discovery？Because it allows you to directly form ternary complex in the presence of our lead-like small molecule collection during the incubation process and MS will provide precise detection for the analysis. Compared with traditional HTS, ASMS is specialised in identifying affinity-based protein modifiers with much cheaper and faster manner. With the help of our versatile compound library in WuXi AppTec, you could take off your journey in Molecular Glue design from here right away! Please reach out to me or Mahnaz Arjomand for more discussions! #WuXiAppTec #ASMS #DrugDiscovery #MolecularGlue

?? New Application Note for Cell Line Development Researchers! ?? Are you working with bispecific antibodies and looking to streamline your cell line development process? Our latest Application Note demonstrates how to identify high-quality bispecific antibodies in just days using the Beacon? platform with SpotLight reagents! In this Application Note, you'll discover how to: ? Identify top clones early, with optimal growth, titer, and product quality attributes—before scale up. ?? Screen a broad range of cell lines, including those expressing traditional mAbs and complex formats like bispecific antibodies with Lambda-Kappa light chains. ? Accelerate the identification of cell lines producing molecules in the desired format, cutting down development timelines. Download now: https://hubs.ly/Q02VG6JR0 #CellLineDevelopment #AntibodyResearch #BeaconPlatform #BiologicsDevelopment #BiotechInnovation #BispecificAntibodies

We're excited to invite you to an exclusive webinar that delves deep into the world of antibodies and their critical role in lateral flow immunoassays. ?? Join us as our expert unravels the complexities of antibody structure and function, providing insightful knowledge on their practical applications in lateral flow technology. This session is designed to enhance your understanding of antibody selection and usage, complete with actionable advice on screening methodologies to optimize antibody performance in LFAs. ?? **Don't miss this opportunity to learn from the best and elevate your expertise in lateral flow assays.** ?? Looking forward to seeing you there! #LateralFlowTech #Antibodies #Webinar #LifeSciences #Biotechnology #Innovation

Better together with qPCR and dPCR

The pull-down assay is a technique developed to verify the physical interactions between proteins in vitro, which can also be used to confirm a predicted protein-protein interaction and identify novel interacting partners.?This method typically involves the affinity capture process using bait protein-coupled supports and various wash and elution steps, which are tedious and time-consuming. CD Bioparticles provides a series of pull-down kits that contain the necessary components for protein capture and purification to make pull-down assays easier and more efficient. https://lnkd.in/g2TFUZZ3

Fully functionalized probes?are designed to speed up and simplify the early stages of drug development. The introduction of the diazirine photocrosslinking moiety along with the presence of a functional acetylene group allows the screening of compounds directly in cells. In recent work, Offensperger et al. used a chemical proteomics approach to map protein-ligand interactions across the human proteome. With a library of around 400 small-molecule fragments from #Enamine ’s catalog (harboring a diazirine moiety for photocrosslinking and an alkyne functionality for click reaction and enrichment), authors integrated machine learning to predict interactions within biological systems (https://lnkd.in/dd9Tvs8T). Enamine currently has almost?8?000?fully functionalized compounds in stock and more than 1 million molecules in?REAL?Database. The most diverse compounds have been selected and sorted out into a small library, which has been pre-plated for the most convenient and fast delivery to our clients. For more details about Enamine Fully Functionalized Probe Library https://lnkd.in/dkwpPsij

Improve the efficiency of high-throughput biological assays and avoid inconsistencies caused by manual pipetting errors with PIPETMAX?. PIPETMAX reduces costs and increases reproducibility by eliminating common pipetting errors. With a volume range from 1 μL to 1200 μL, this automated pipette system is an ideal solution for: ?? qPCR ?? NGS reactions ?? Cell-based assays Learn more about this compact but powerful solution for your lab: https://bit.ly/4ev9iOb #PIPETMAX #AutomatedPipetting #HighThroughputAssays #LabAutomation #qPCR #NGS #CellBasedAssays #PipettingAccuracy #LabEfficiency #LifeSciences #Biotech #LabInnovation #LaboratoryEquipment #Reproducibility #ScientificResearch