FoundersX Superstars的动态

?? Single Cell Atlas: a single-cell multi-omics human cell encyclopedia Pan et al. constructed a single-cell multi-omics map of human tissues through in-depth characterizations of multi-omics datasets across 125 healthy adult and fetal tissues. Key points ??Data from scRNA-seq, scATAC-seq, scImmune profiling, mass cytometry, flow cytometry, spatial transcriptomics, bulk RNA-seq and whole-genome sequencing ??The inter-/intra-tissue and cell-type variabilities in molecular phenotypes, immune repertoire variations, and the interplay between multiple omics ??The extensive effects of monocyte chemoattractant family ligands on interactions between fibroblasts and other cell types ?? Web-based platform available at www.singlecellatlas.org ?? More details: https://lnkd.in/gkVRCbqX #spatialomics #spatialbiology #singlecellanalysis #singlecell

Have you ever wondered about the differences between mice and human? CPI researcher Mariano Ruz Jurado and colleagues of the Goethe-Universit?t Frankfurt show bioinformatical data about common and unique signatures of #heart failure in mice and humans in their recent publication. Cardiovascular research often relies on mouse models, but translating findings to human patients remains a challenge. To address this, a comparison of disease models in mice with human diseased tissue is crucial. Using the OrthoIntegrate pipeline, Jurado and colleagues compared single-cell RNA sequencing data from heart failure patients and a mouse model, discovering both share distinct regulatory pathways, highlighting the need for careful validation of mouse model findings in human patients. The publication can be found here: https://lnkd.in/esSYzdZJ

Sarah McCann and I from the QUEST Center for Responsible Research will present at the 11th International Symposium on Neuroprotection which will take place from November 18th to 20th 2024 in Potsdam, Germany. Sarah will start with presenting the results from our large meta-research project "Systematic review and meta-analysis of the impact of age and comorbidities on stroke severity and treatment efficacy in animal models of focal cerebral ischaemia (StrokeComorb)" in which we highlight important aspects of external validity of #stroke models to consider for successful #translation from the experimental setting to clinical testing. Her talk will be on Tuesday morning. I will present first results from our project "Investigating concordance between preclinical multicentre confirmatory trials and systematic reviews in stroke (INFORM-Stroke)" in which we synthesize the available evidence to each of the interventions from the Stroke Preclinical Assessment Network (SPAN) 1.0 to later compare them to the effect estimates from SPAN. Here, I present data on a systematic review on Tocilizumab on stroke outcome. My presentation will be on Wednesday morning. Looking forward to see many of you there. CAMARADES https://lnkd.in/dr6sie_Y

Happy Wednesday all! Check out this open access JEM review by Francesca Pala, Luigi D. Notarangelo, and Marita Bosticardo,?"Rediscovering the human thymus through cutting-edge technologies." https://lnkd.in/gBFUVGFQ Summary: Recent technological advances have transformed our understanding of the human thymus. Innovations such as high-resolution imaging, single-cell omics, and organoid cultures, including thymic epithelial cell (TEC) differentiation and culture, and improvements in biomaterials, have further elucidated the thymus architecture, cellular dynamics, and molecular mechanisms underlying T cell development, and have unraveled previously unrecognized levels of stromal cell heterogeneity. These advancements offer unprecedented insights into thymic biology and hold promise for the development of novel therapeutic strategies for immune-related disorders. #drugdiscovery #immunology #thymus #cancerresearch #tcelltherapy #immunooncology #scientificresearch

?? Wrapping up Multi-Omics 2024 in Brisbane, Australia! ?? Our Director of Biomedical Research, Dr. Ettai Markovits, presented results from our study, showcasing how Nucleai’s deep learning-based multiplex imaging pipeline unveiled distinct immune and metabolic states associated with immunotherapy outcomes in NSCLC patients. These insights have the potential to advance personalized therapeutic strategies and contribute to improved patient outcomes. Thank you to our collaborators at The University of Queensland, Dr. Arutha Kulasinghe & Dr. James Monkman, and at Yale University, Prof. David Rimm, and Dr. Thazin N Aung ?? Want to learn more? Let’s connect! https://lnkd.in/gzaYX2xF #Multiomics24 #SpatialBiology #SpatialBiomarkers #biomarkers #AIPathology #DigitalPathology #LungCancer #NSCLS #mIF #Immunotherapy

?? Will you be attending the Cell Engager Summit??? Our team of Business Developers and scientific experts will be present at the 6th edition of the conference on May 21-23, 2024, in Boston. On Wednesday, May 22, at 11:30 a.m. EDT, Kader Thiam, our Senior Vice President - Discovery, Preclinical Models and Services, will give a presentation entitled: "How to Enhance Translatability of Immunotherapies in Preclinical Models?" ?? The presentation will focus on: ? Syngeneic humanized mouse models and #BRGSF-HIS hCD34+ reconstituted mice featuring human lymphoid and myeloid compartments? ? Characterization of the immune response in the mice ? Assessment of efficacy and safety induced by cell engagers If you plan on attending, don't miss the opportunity to connect and exchange with our team! Book your ticket to the conference here ?? https://lnkd.in/eC_yb-nV Learn more about our BRGSF-HIS mouse here ?? https://lnkd.in/eFxhmuss Learn about our syngeneic mouse models here ?? https://lnkd.in/eswQmRYD #6thcellengagersummit #cancerresearch #cellangagers

Investigating the dynamics of mRNA-LNPs in mice and non-human primates: in their latest study, Christine Prost at Sanofi, Roger Le Grand at Université Paris-Saclay and collaborators employed a combination of in vivo imaging techniques to study vaccine migration from the injection site to draining lymph nodes, examining interactions with local immune cells while comparing the dynamics and biodistribution of two different LNP formulations https://lnkd.in/ewhxiDh8 Their study demonstrated how the nature and physicochemical properties of the LNP delivery vehicle, including surface characteristics and in vivo mRNA release susceptibility, influence the mRNA's in vivo distribution. An article co-authored by katia lemdani, Romain Marlin, Céline Mayet, Vladimir Perkov, Quentin PASCAL, Manon Ripoll, Francis Relouzat, Nina DHOOGE, Laetitia Bossevot, Nathalie Dereuddre-Bosquet, Gihad Dargazanli, Kevin Thibault-Duprey, Jean Haensler and Catherine Chapon #LNPs #mRNA #microscopy #imaging #biodistribution #Vesiculab

It is time to meet at the Cell Engager Summit on May 21-23, 2024, in Boston. On Wednesday, May 22, at 11:30 a.m. EDT,?Kader Thiam, our Senior Vice President - Discovery, Preclinical Models and Services, will give a presentation entitled: "How to Enhance Translatability of Immunotherapies in Preclinical Models?" ?? The presentation will focus on: ? Syngeneic humanized mouse models and?#BRGSF-HIS hCD34+ reconstituted mice featuring human lymphoid and myeloid compartments? ? Characterization of the immune response in the mice ? Assessment of efficacy and safety induced by cell engagers If you plan on attending, don't miss the opportunity to connect and exchange with our team! Book your ticket to the conference here ???https://lnkd.in/eC_yb-nV Learn more about our BRGSF-HIS mouse here ???https://lnkd.in/eFxhmuss Learn about our syngeneic mouse models here ???https://lnkd.in/eswQmRYD

Humanized mice stand at the forefront of translational medicine, bridging the gap between laboratory findings and clinical applications. These advanced models, engineered to incorporate human biological components such as DNA, cells, and immune systems, offer unprecedented insights into human physiological responses. Key advantages: Enhanced accuracy in simulating human biological processes Improved reliability of preclinical research results Accelerated development of novel therapeutic interventions Are you developing the next breakthrough therapy? Discover how our humanized mouse models can accelerate your research. Fill out our inquiry form to learn more about custom solutions for your specific indication - https://gvrp.in/enquiry/ ................... GV Safety Assessment Platform (GVSAP), a subsidiary of GV Research Platform (GVRP) is an authorised distributor of Biocytogen humanized mice models in India. ................................. #researchmodels #preclinicalresearch #humanizedmicemodels #biomedicalresearch #advancedtools #precisiononcology

TREAT-NMD is thrilled to announce an in-person, expert-led one-day symposium on Duchenne Muscular Dystrophy (DMD) in Prague, Czech Republic, on July 11th, 2025! This event is perfect for industry professionals new to the field of Duchenne and those seeking a comprehensive overview of this complex area. ?? Topics Covered ? Clinical aspects of the disease ? Disease management ? Genetic causes and pathophysiology ? Preclinical tools and models ? DMD therapeutic landscape ? Clinical trial design ? Outcome measures for therapy development ?? Objectives ?? Equip participants with practical insights to apply in their work ?? Create a collaborative platform for sharing ideas, addressing challenges, and celebrating successes ?? Limited Places Available! Be the first to know when registration opens—complete the expression of interest form now! ?? https://lnkd.in/eU3yWiQB #Duchenne #TREATNMD #NeuromuscularDiseases #DMD #LifeSciences #Prague2025