The American Academy of Allergy, Asthma and Immunology - AAAAI and the American College of Allergy, Asthma and Immunology (ACAAI) Joint Task Force recently released updated guidelines for AD management, encompassing several of the latest medications and addressing five crucial questions related to AD management: 1. Among patients with AD, what topical treatments should be used to achieve optimal outcomes? 2. Should elimination diets (dietary avoidance strategies) be used for AD? 3. Should dilute bleach baths be used for AD? 4. Should allergen immunotherapy be used for AD? 5. Among patients with AD, what systemic treatments, including phototherapy (UV light therapy), should be used to achieve optimal outcomes? In this article, we provide an overview of essential discoveries and delve into the practical consequences in a clinical context. https://lnkd.in/dDbh_wrX Peter Lio, MD Gabrielle Osher Derek Chu, MD, PhD

Article sharing~ ?? Title: A practical guide to recognize allergic and immunologic skin diseases: diagnosis at first sight ?? Authors: Cataudella E, Perlato M, Salvati L, Di Agosta E, Romaldi A, Paolino D, et al. ?? Introduction: “People wear their health on their skin”, said Lauren Gravitz, and we have the responsibility to understand what it is telling us. To guide us through this process, the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC) and Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) organized the GET TOGETHER 2022 initiative. It consisted of virtual meetings held by specialists in allergic and immunologic skin diseases in Italy between September and December 2022. Its primary aim was to discuss and review the current knowledge on the differential diagnosis of contact dermatitis (CD), atopic dermatitis (AD), hereditary angioedema (HAE), urticaria, and cutaneous mastocytosis (CM). This document aims at providing a reference tool for the clinician who is faced with the onset of a new skin manifestation, considering the increasing prevalence of allergic and immunologic skin disorders. Read the full text at : https://lnkd.in/gBdteWrT ?? Keywords: #Differential #diagnosis, #skin, #contact #dermatitis, #atopic #dermatitis, #hereditary #angioedema, #urticaria, #cutaneous #mastocytosis, #allergy

Understanding Glucocorticoids in Acute Urticaria: A Clinical Perspective Acute urticaria, or sudden-onset hives, is a frequent challenge in urgent care and emergency settings. But when it comes to the role of glucocorticoids (steroids), recent evidence points to an intriguing finding: their benefit remains unclear. Two systematic reviews from 2024 have put the spotlight on this common practice: 1. Jamjanya et al. in the Journal of Allergy and Clinical Immunology concluded that parenteral antihistamines are the most effective intervention, while the added value of glucocorticoids wasn’t definitive. 2. Badloe et al. in the Journal of the European Academy of Dermatology and Venereology echoed similar findings, casting doubt on the routine use of glucocorticoids. What does this mean for our clinical practice? ?? Key Takeaway: Nonsedating second-generation antihistamines should be the first-line therapy for acute urticaria. Glucocorticoids should be reserved for specific situations—such as prominent angioedema or persistent symptoms despite several days of antihistamine therapy. Let's stay updated with evidence-based practices to provide the best patient care! ?? #Healthcare #EmergencyMedicine #EvidenceBasedPractice #Allergy #Urticaria #ClinicalUpdates #Pharmacology #PatientCare

?? Dive into the nuances of skin allergies and immunology with this insightful article! ?? 'A practical guide to recognize allergic and immunologic skin diseases: diagnosis at first sight'. ?? Explores differential diagnosis of various skin conditions. Don't miss out! ?? Read Full Article: https://lnkd.in/gBdteWrT #DifferentialDiagnosis #SkinHealth #AllergyAwareness

?? New publication alert: High content of hexavalent chromium in cement samples from three African countries (https://lnkd.in/e-Gv3bTb) ?? Hexavalent chromium is an important contact allergen traditionally found in cement This study showed that in six of eight cement samples from three African countries, the Cr(VI) content was ≥16 mg/kg, more than eight times the maximal allowed concentration in the EU. This finding suggests that high hexavalent chromium concentrations in cement in three African countries may contribute to the high prevalence of chromium contact allergy seen in these regions. Regulating the allowed levels of contact allergens in commonly used substances is key to preventing contact allergy across the world!

?? Publication alert: ESCD position paper on patch testing ?? Patch testing is the only clinically applicable diagnostic method for Type IV allergy. The availability of Type IV patch test (PT) allergens in Europe, however, is currently scarce. This severely compromises adequate diagnostics of contact allergy, leading to serious consequences for the affected patients. ? Against this background, the European Society of Contact Dermatitis (ESCD) has created a task force (TF) (i) to explore the current availability of PT substances in different member states, (ii) to highlight some of the unique characteristics of Type IV vs. other allergens and (iii) to suggest ways forward to promote and ensure availability of high-quality patch testing substances for the diagnosis of Type IV allergies throughout Europe. ? The suggestions of the TF on how to improve the availability of PT allergens are supported by the ESCD, the European Academy of Allergy and Clinical Immunology, and the European Academy of Dermatology and Venereology and intend to provide potential means to resolve the present medical crisis. Full text available at (open access): https://lnkd.in/dgR5mGZd #science #allergy #dermatitis #dermatology

I think it's important not to assume that everyone knows what Allergy and Clinical Immunology are all about. While many patients are familiar with specialties like Cardiology, Pulmonology, Nephrology, and Dermatology, understanding the subject matter of Allergy and Clinical Immunology, especially Clinical Immunology, can be less common. Read more about this topic in our article: https://lnkd.in/gTss_2fN #ClinicalImmunology #AllergyAwareness

?? ?????? ???????????????? ???????? ???????? ?????????????? ?????????????? ???? ???????????????????? ???????????????? Exciting news! Mikkel Bak Jensen MD, PhD student and co-authors have recently published a systematic review and meta-analysis exploring the prevalence of contact allergy to gold among dermatitis patients from 2010 to 2024. ?? Findings from 16 studies involving 14,887 patients showed a significant pooled prevalence of 14.1%. This high prevalence emphasizes the need for further research to assess the clinical relevance of positive patch tests, which remains underexplored. ?? How can we improve diagnostic accuracy and patient management based on these findings? Let's discuss! ???? https://lnkd.in/d4gi-B8X #Dermatology #Allergy #GoldAllergy #ClinicalResearch

The #skin is the largest immune organ, acting as a protective layer between the body and the environment. Microbial dysbiosis of the skin has been observed in atopic dermatitis patients, characterized by a loss of microbial diversity and an overabundance of pathogenic Staphylococcus aureus. This microbial imbalance stimulates the production of inflammatory cells, such as T cells, dendritic cells, and macrophages, contributing to disease severity, and perpetuating inflammation, itching, and further disruption of the skin barrier. In this issue, Wang et al., in their comprehensive review, highlight the impact of climatic hazards linked to greenhouse gas emissions and atopic dermatitis. Tham et al. review the skin microbiome in pediatric atopic dermatitis and food allergy. Canani et al. provide an overview of the epithelial barriers of the skin, digestive tract, and airways, and explore how barrier dysfunction affects the course of allergic and inflammatory conditions. Müller and Maintz et al., in their review of treatments for atopic dermatitis, provide an update on recently approved biologics and oral Janus kinase (JAK) inhibitors. Del Duca and Dahabreh et al. evaluate transcriptomics of skin tape-strips in children with allergic asthma and uncover epidermal barrier dysfunction and biomarker abnormalities. Ruchti et al., using a mouse model, demonstrate that epidermal barrier impairment predisposes to excessive growth of Malassezia on the skin. Fritz et al. reveal key differences between tape-strips and biopsies in the identification of gene-expression changes in atopic dermatitis. Guttman-Yassky et al. provide evidence that IL-13 targeting with tralokinumab normalizes type 2 inflammation in atopic dermatitis. Rademacher et al. present a novel role of RNase inhibitor as a trigger factor of inflammation in atopic dermatitis by blocking the ribonuclease and antimicrobial activity of RNase 7, thereby enhancing the growth of Staphylococcus aureus. Jin and Lee et al. describe a novel Th2-proming subset of dendritic cells, particularly prevalent in severe atopic dermatitis. M. Kim, J. Kim, Kang, Heo, and Kang et al. evalute the efficacy and safety of topical Streptococcus postbiotic emollient in atopic dermatitis. Aoyama, Nakagawa, and Ichikawa et al. study the skin dysbiosis in atopic dermatitis from the neonatal stage to infancy. Craig et a. use a naturally occurring canine model of atopic dermatitis to examine IL-31 transcription in the skin over the course of an acute allergic flare and following chronic inflammation. Lam et al. demonstrate that SM17, a new IL-17RB-targeting antibody, ameliorates disease progression in a mouse model of atopic dermatitis. The cover image depicts the colony Staphylococcus aureus. Photo credit: ? M Oeggerli 2007, supported by Pathology, Univ. Hosp. Basel and School of Life Sciences, FHNW, Muttenz.

Fun fact: all the papers that will be included to my doctoral dissertation have been published on an October. Here’s our latest paper on the immunosuppressive effects of nanosized zinc oxide on a contact hypersensitivity mouse model. https://lnkd.in/dY5yfAZk Contact hypersensitivity, or contact allergy, is a common skin condition affecting around 15-20 % of the general population and in humans one common contact allergen is nickel. Despite the wide use of nanosized zinc oxide (nZnO), not much is known about the molecular mechanisms of nZnO interaction with damaged skin. We used a contact hypersensitivity mouse model to identify whether nZnO has any immunomodulatory effects on allergic inflammation. While nZnO did not prevent sensitisation to our contact allergen, when the mice were re-exposed to the contact allergen and simultaneously treated with nZnO, the development of an allergic response was fully blocked. Treatment with nZnO inhibited pro-inflammatory pathways and recruitment of immune cells. We found the anti-inflammatory action could be achieved with both nZnO particles and Zn2+ ions. Our results could be beneficial for people with contact allergy and can be useful when developing skin products containing nanoparticles.