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Another big win for patients with HFpEF and obesity .. Tirzepatide showed a 38% reduction in heart failure outcomes and improved symptoms in adults with HFpEF and obesity. SUMMIT trial topline results announced today by Lilly waiting for the full study results. Future is bright for incretin-based therapies to become foundational in HFpEF ???? #tirzepatide #obesity #HFpEF #lilly https://lnkd.in/dHmDcmVx

The recent publication in The Lancet Diabetes & Endocrinology delves into the pertinent issue of the stigma and discrimination endured by individuals living with diabetes. This comprehensive study presents tangible measures aimed at eradicating the stigma associated with diabetes, shedding light on the paramount significance of collective action as a society to tackle this matter. It is incumbent upon each and every one of us to bear the weight of responsibility in fostering a more equitable and empathetic society. https://lnkd.in/dRZpSYka

SYNCHRONIZE-1 and -2 will provide "robust evidence" on the safety, efficacy, and tolerability of #survodutide in adults with obesity with or without #T2D. ?? https://lnkd.in/eTeQzXCn

Gestational diabetes in twin pregnancies—a pathology requiring treatment or a benign physiological adaptation? Identification of twin-specific OGTT criteria in relation to future maternal risk of diabetes The incidence rate of maternal type 2 diabetes (per 1000 person-years) was modeled as a function of the 75-g OGTT results using a multivariable fractional polynomial regression. Models were adjusted for maternal age at the time of the index birth, ethnicity, income quintile, and fetal sex. Separate models were developed for the fasting (A), 1-hour (B), and 2-hour (C) values in twin (red dashed line) and singleton (blue solid line) pregnancies. The dashed arrows indicate the twin-specific OGTT cutoff values associated with a similar incidence of future type 2 diabetes as that observed in singleton pregnancies using the currently used cutoff levels recommended by Diabetes Canada for fasting. The table compares the current recommended Diabetes Canada criteria with the newly developed twin-specific criteria. https://ow.ly/wA6s50Svp7F

New research suggests that Intravenous (IV) ketamine could be a game-changer in treating severe refractory headaches in children. A refractory headache refers to a type of headache that is resistant to conventional treatments, making it particularly challenging to manage and alleviate. This groundbreaking treatment offers hope for children struggling with severe headaches who haven't responded to other treatments. Want to learn more about this fascinating research? Click the link below to read the full article and discover how IV ketamine could revolutionize headache treatment for children. https://lnkd.in/gb2PDe5a #KetamineTreatment #HeadacheRelief #MedicalResearch #InnovativeTreatment #ChildrensHealth

In ~1000 adults 40-65 years old with a 10-year risk of <5%, prevalence of coronary atherosclerosis was 36% (51% men; 24% women) and 3.4% had ≥1 high-risk plaque feature. Lp(a) was one of the highest associated factors with atherosclerosis demonstrating an adjusted odds ratio of 1.46 #knowLpa https://lnkd.in/g7-udjBP

Telephone lifestyle intervention to prevent diabetes in women with recent gestational diabetes mellitus attending the national health system: the LINDA-Brasil clinical trial What are your thoughts on this? Objectives To evaluate a postpartum telephone-based lifestyle intervention to prevent diabetes in high-risk women with recent gestational diabetes mellitus

https://lnkd.in/gFuWXuKQ #diabetes #inflammation #aspirin #diseaseprevention #endocrinology Background Inflammation has been implicated in the pathogenesis of diabetes. This study investigated the randomised treatment effect of low-dose aspirin on incident type 2 diabetes and fasting plasma glucose (FPG) concentrations among older adults. Methods ASPREE was a double-blind, placebo-controlled trial of daily oral low-dose aspirin. The study population included community-dwelling individuals aged 70 years or older (≥65 years for US minority ethnic groups) in the USA and Australia who were free of cardiovascular disease, independence-limiting physical disability, or dementia Interpretation Aspirin treatment reduced the incidence of type 2 diabetes and slowed the increase in FPG concentration but increased major bleeding among community-dwelling older adults. Given the increasing prevalence of type 2 diabetes among older adults, the potential for anti-inflammatory agents such as aspirin to prevent type 2 diabetes or improve glucose levels warrants further study with a comprehensive assessment of all potential safety events of interest.

https://lnkd.in/dXvVA6hc. Amazing results for tirzepatide in people living with obesity and HFPEF! All co-1ary and key 2ary enpoints were met. It adds another "layer of marble blocs" on the new fast growing pillar for the treatment of patients with this condition. #Obesity #heartfailure #GLP1

?? Exciting news in medical research! ??Read more: https://bit.ly/3xACrHQ ?? A recent study found that women lost more body weight on average with semaglutide than men. ?? Researchers performed a secondary analysis within the STEP-HFpEF program, which included individuals with diabetes mellitus. ?? The study specifically looked at the effects of semaglutide in people with obesity and heart failure with preserved left ventricular ejection fraction. ?? This groundbreaking research highlights the importance of considering biological sex in treatment outcomes. ?? Let's stay informed and support continued advancements in healthcare! ?? Credit: The Journal of the American College of Cardiology #CRP #WeightLoss #ObesityTreatment #Diabetes #HealthcareInnovation #healthcare #meded #eMednews