Department of Physiology, Anatomy & Genetics - University of Oxford的动态

This year, HBHL welcomed Western University's Jibran Khokhar, McGill University's Dr Jelena Ristic, PhD and The Neuro (Montreal Neurological Institute-Hospital)'s Adrián Noriega de la Colina, MD PhD on stage for the Amazing Brain Science Talks. ???? Want to learn more about their research? Check out their Q&A Session for insights on the following topics: ?? The legalization of cannabis in Canada and the effects of THC and CBD on the brain ?????? The effect of COVID and masking on eye contact, and how different cultures, relationships and age groups affect social communication ?? The Alzheimer's Disease Continuum and the benefits of personalized medicine for dementia patients Watch now: https://mcgill.ca/x/wrq McGill Research + Innovation | Brain Canada | Perceiv AI | BrainsCAN at Western University | McGill Faculty of Medicine and Health Sciences

If you missed Dr. Lucina Q. Uddin's presentation "Taxonomy of Large-Scale Brain Networks", you can watch the recording at this link: https://lnkd.in/gHUff2_3

Atlantic Council The Atlantic Council asked healthcare experts to weigh in on how #MENA could improve healthcare efficiency. #ML #AI #machinelearning #digitalhealth #IoMT #wearables My response: MENA is a very diverse region; even within a given country or kingdom, there is much heterogeneity with respect to incomes, access, and cultural norms around health. To improve healthcare efficiency, governments will need to increase public health expenditure, diversify financing sources, and implement targeted interventions to address workforce shortages and inequities in access to care. Emphasizing preventive care, wearable and passive IoT technology at the edge, adopting advanced health information systems, deploying machine learning/AI in edge-based computing systems, and enhancing regulatory frameworks are essential.

"Neuroscientist Vivek Jayaraman on daring to pursue less-traveled paths in science" Read our interview with Howard Hughes Medical Institute (HHMI) neuroscientist Dr. Jayaraman, one of our #50ScientistsThatInspire: https://lnkd.in/efv6QhXu

?? Have you seen the latest episode of our Science Spotlight series yet? We are joined by Dr. Stuart Greenhill who showcases innovative wireless implants that can record neural activity. By watching, you will learn how these implants support translational research into conditions such as epilepsy and schizophrenia. Watch the full episode for FREE: https://lnkd.in/e_S3dzhM What is Science Spotlight? ?? This series explores the why, what and how behind scientists' work as they discuss their research via a poster presentation. Are you looking to share your poster with a wider audience? Drop a comment below or DM us!

Nearly 50 years ago, neuroscientists discovered cells within the brain’s hippocampus that store memories of specific locations. These cells also play an important role in storing memories of events, known as episodic memories. While the mechanism of how place cells encode spatial memory has been well-characterized, it has remained a puzzle how they encode episodic memories.A new model developed by MIT researchers explains how those place cells can be recruited to form episodic memories, even when there’s no spatial component. According to this model, place cells, along with grid cells found in the entorhinal cortex, act as a scaffold that can be used to anchor memories as a linked ser ...

It's incredible how, through hard work and research, we are now able to map a tiny section of the human brain cortex in colored, millimeter-scale detail. This groundbreaking achievement is thanks to the collaboration between Google Research and the Lichtman Lab at Harvard University, who have made significant progress in exploring the various neural arrangements within the brain cortex. Check out the article here: https://lnkd.in/dA_jrYJE

We are excited about the #ProbiotaAmericas conference this week.?Our Discovery Team Lead, M. Adnan Qureshi, Ph.D. will be presenting on?"A Preclinical Cognitive Health Platform for Discovering Biotics Targeting the Gut-Brain Axis" at this meeting!? ? In humans, cognitive health is assessed by a variety of endpoints including memory, learning, reasoning, focus, concentration and alertness. The C. elegans model has been used for cognitive phenotypes like memory and learning, however these readouts are low throughput and not conducive for bioactive screening.?At the meeting, Dr. Qureshi?will present an innovative approach to measure alertness-like phenotype for high throughput bioactive screening, paving the way for developing new biotics that modulate gut-brain axis and boost cognition!? ? Stay tuned for more updates! #CognitiveHealth #GutBrainAxis #Biotics #HighThroughput #Innovation #NemaLife?

This work is one of my favorites! Can postbiotics have nootropic properties similar to the world’s widely used stimulant, caffeine? Do they help with wakefulness or alertness by modulating the gut-brain axis? How do the biotics compare with known cognition boosters: caffeine, botanicals, vitamins? Check out M. Adnan Qureshi's presentation at #ProbiotaAmericas. Here is what it took us in our search for nootropics. ** It required biologists, microfluidic engineers and AI developers at NemaLife to come together to pull this feat of measuring an alertness-like phenotype in worms at scale, and across worm-life. ** C. elegans responds to touch. Mechanosensory neurons and the underlying neural circuitry are activated upon touch which leads to a striking fight or flight response. This reflexive response declines with age similar to loss of tactile function in older people. ** Traditionally the touch assay required gentle stroking of the worm with an eyelash or eyebrow hair to record the reflexive response. Worm-by-worm, graduate students and postdocs would do this to painstakingly (and yes pulling their own eyelashes) to dissect the genetics and neural circuitry underlying the biological meaning of touch. ** How can we speed the touch assay? At NemaLife, we use microfluidic chips?to culture worms with daily fluid injection of media/food to feed and washout-progeny. It is well known in biomechanics that fluid stresses induce cellular mechanotransduction. Can the fluid stress mimic touch-like behavior and elicit an organismal response? The answer was yes. This solved the eyelash problem! ** Best-in-class AI: The next major challenge was getting the reflexive response data from the videos. When the fluid flow is introduced into the chip, tracking the response of dozens of worms in the chip requires eliminating noise from debris, progeny, bubbles etc..We worked through several refinements of our AI model, to finally get the multi-worm detection and tracking right. Each stimulus and worm tracking generated 70,000 data points of reflexive response. How to scale this compute for several hundreds of chips per day - that is a story for another day! ** How do we know the touch-based reflexive response captures aspects of alertness. We tested mutants defective in touch-sensation as well as bioactives that are neurostimulants. This effort required analyzing more than a million images to extract phenotypic data on this reflexive response, and a data team to collate, synthesize and interpret the essence to define postbiotics that could be cognition boosters.

Heads up, brain scientists! ICERM has a number of great courses coming up this summer and fall. Check out the full list of offerings @ bit.ly/ICERMsummerfall24 #ComputationalBrainScience #BrownBrainScience!