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Scientists Edit HIV Out Of Cells, Paving The Way For A Potential Cure. Researchers have taken a promising step toward an HIV cure using CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), a powerful gene-editing technology. This approach involves using CRISPR, likened to molecular scissors, to cut HIV's DNA out of infected cells. While existing treatments suppress HIV, they can't eliminate it. This new research, though in its early stages, offers hope for a complete eradication of the virus. Globally, about 39M people are living with the virus. The Ghana AIDS Commission reported that 354,927?people are living with HIV/AIDS in Ghana in 2022. This includes adults, children, adolescents, and young people. While this is a great advancement in medicine, we are thinking about the cost of treatment for the African.

CBD may be a promising therapy for people living with HIV. FIU researchers found CBD’s anti-inflammatory effects can essentially keep HIV-infected cells in the brain under control, preventing them from acting up. This is important because neuroinflammation associated with HIV creates a dangerous domino effect: inflammation causes infected cells hiding in the brain to activate, start the replication process and spread the virus back into the body. As published in?Scientific Reports, the team showed CBD works at the molecular level to lower inflammation and keep these cells dormant. The suppression of both inflammation and the HIV-infected cells is key because of the way HIV acts. After it hijacks the immune cells in the bloodstream, HIV hitches a ride through the blood-brain barrier — designed to stop harmful substances from entering the brain. Once there,?the virus targets microglia, the brain’s immune cells. These infected cells then go into a sort of hibernation. “Even though HIV crosses the blood-brain barrier, antiretroviral medicines that keep the virus from replicating cannot effectively cross the blood-brain barrier, and so the brain becomes a repository for HIV," explains Adriana Yndart, the study’s first author and?FIU Robert Stempel College of Public Health & Social Work?Ph.D. student. Read more: https://lnkd.in/eRQSPKYJ #publichealth #cbd #HIV #research

A groundbreaking test developed by Weill Cornell Medicine, highlighted in a new study, offers a significant advancement in measuring HIV persistence in individuals affected by prevalent viral strains in Africa. This development is crucial given the focus of most HIV research on strains common in Western nations, emphasizing the need for a cure effective across all strains. The test allows researchers to identify intact HIV proviruses capable of generating new viruses, a key breakthrough even when current treatments can reduce the virus to undetectable levels in the blood. This achievement represents a pivotal milestone in the ongoing pursuit of an HIV cure. Researchers found that the composition of the HIV proviral reservoir remains similar between African subtypes and those in North America and Europe, suggesting the potential for using comparable strategies to target these reservoirs. Further studies are needed to validate these findings.

Researchers of Amsterdam University Medical Centre claimed that they were able to cut HIV virus from infected cells with the help of Nobel Prize-winning Crispr gene-editing technology. Crispr, co-discovered by Emmanuelle Charpentier and Jennifer Doudna, is a technology to edit genomes by removing, adding or altering sections of the DNA sequence with precision and efficiency. The study noted that when people initially contract HIV, the virus inserts its DNA into the host's immune cells and stays dormant as long as the person takes medication. In case, the infected person stops taking medicines, the virus re-activates and spreads through the immune system again. The research team led by Elena Herrera-Carillo stated, "Our aim is to develop a robust and safe combinatorial Crispr-Cas regimen, striving for an inclusive 'HIV cure for all' that can inactivate diverse HIV strains across various cellular contexts." #HIVtreatment #HIVmedication #HIVnews #HIVhealthcare #healthcarenews #healthcareinnovations #usanews #usahealthcarenews #immunesystems #amsterdamuniversity #HIVresearch #virusresearch

Image source, Getty Images By Michelle Roberts Digital wellness editor Scientists accidental they person successfully eliminated HIV from infected cells, utilizing Nobel Prize-winning Crispr gene-editing technology. Working similar scissors, but astatine the molecular level, it cuts DNA truthful "bad" bits tin beryllium removed oregon inactivated. The anticipation is to yet beryllium capable to escaped the assemblage wholly of the virus, though overmuch much enactment is needed to cheque it would beryllium harmless and effective. Existing HIV medicines tin halt the microorganism but not destruct it. The University of Amsterdam team, presenting a synopsis, oregon abstract, of their aboriginal findings astatine a medical league this week, accent their enactment remains simply "proof of concept" and volition not go a cure for HIV immoderate clip soon. And Dr James Dixon, stem-cell and gene-therapy technologies subordinate prof astatine the University of Nottingham, agrees, saying the afloat findings inactive necessitate scrutiny. "Much much enactment volition beryllium needed to show results successful these compartment assays tin hap successful an full assemblage for a aboriginal therapy," helium said. "There volition beryllium overmuch much improvement needed earlier this could person interaction connected those with HIV." 'Extremely challenging' Other scientists are besides trying to usage Crispr against HIV. And Excision BioTherapeutics says aft 48 weeks, three volunteers with HIV person no superior broadside effects. But Dr Jonathan Stoye, a microorganism adept astatine the Francis Crick Institute, successful London, said removing HIV from each the cells that mightiness harbour it successful the assemblage was "extremely challenging". "Off-target effects of the treatment, with imaginable semipermanent broadside effects, stay a concern," helium said. "It truthful seems apt that galore years volition elapse earlier immoderate specified Crispr-based therapy becomes regular - adjacent assuming that it tin beryllium shown to beryllium effective." HIV infects and attacks immune-system cells, utilizing their ain machinery to marque copies of itself. Even with effectual treatment, immoderate spell into a resting, oregon latent, authorities - truthful they inactive incorporate the DNA, oregon familial material, of HIV, adjacent if not actively producing caller virus. Most radical with HIV request life-long antiretroviral therapy. If they halt taking these drugs, the dormant microorganism tin reawaken and origin problems again. A uncommon fewer have been seemingly "cured", aft assertive crab therapy wiped retired immoderate of their infected cells, but this would ne'er beryllium recommended purely to dainty HIV. #innovation - #management - #technology - #crea...

Supporting the immune system. Diva Secret International On Viral Load and CD4 Count Viral load explained Viral load is the amount of HIV in the blood. A viral load test shows how much of the virus is in the body by measuring how many particles of HIV are in a blood sample. The results are given as the number of copies of HIV per millilitre of blood – for example 200 copies/ml What is CD4 count and viral load? The amount of HIV in your blood is called “viral load.” Viral load shows how fast HIV is reproducing in your body – the lower your viral load, the better. Your “CD4 cell count” measures the health of your immune system. The higher it is, the better your body can fight infections. Diva Secret Stem Cells are good, effective and quick reactive to a person with low CD4 count and this mostly affects people with HIV etc. Anyone in such conditions is highly recommended to take Diva Secret Stem Cells.

Hey I want to share with you why do a HIV test even without any signs or symptoms of the disease An HIV test is important for several reasons: 1. Early Detection and Treatment: Early diagnosis allows for timely treatment, which can significantly improve health outcomes and quality of life. Antiretroviral therapy (ART) can help manage the virus, reduce the viral load, and prevent progression to AIDS. 2. Preventing Transmission: Knowing your HIV status can help prevent the spread of the virus to others. Individuals who are aware of their status can take measures to protect their partners. 3. Informed Decisions: Knowledge of HIV status allows individuals to make informed decisions about their health, lifestyle, and family planning. 4. Reducing Stigma: Regular testing and open conversations about HIV can help reduce the stigma associated with the virus. 5. Public Health: Widespread testing is crucial for public health efforts to monitor and control the spread of HIV within communities. Attention to All Community Members:"Due to the rising spread of HIV among youths in our country, it is more important than ever to take charge of your health and get tested. Knowing your HIV status is a crucial step in protecting yourself and others. Early detection allows for timely treatment and can significantly improve health outcomes, while also helping prevent the spread of the virus.Getting tested is quick, easy, and confidential. By knowing your status, you can take informed steps to maintain your health and protect your loved ones. Remember, HIV affects individuals from all walks of life, and regular testing is a responsible and proactive measure for everyone.Visit your nearest health center or clinic to get tested today. Together, we can stop the spread of HIV and build a healthier future for our community."

Join us and your technical support ; On going program - TARGET ; UNDERSTANDING T.B STIGMA and HIV [ It is in every community ] - ACTIVITIES; -TUBERCULOSIS [ TB ] is a fatal disease of the lungs , the body caused by germs that create holes in the organs affect. -Tuberculosis [T.B ] attack the glands, brain , pine , hip , intestines . -Tuberculosis it is spread through system. - Tuberculosis [T.b ] SIGNS include feeling , weak , coughing , loss of appetite. - Tuberculosis [ T,B ] is treatable and curable -Tuberculosis [T.b ] patients is not required to be isolated ? once had started treatments you are no longer infectious.This means you can eat , sleep , work together as normal . -T.B and HIV - If you are infected with T.B it does not mean you have HIV or AIDS. - However if you are living with HIV,you may be more vulnerable to catching T.B reason your immune [ de fence ] syStem man be weak . - If you are HIV positive you can take a course of treatment they will prevent you from getting T.B - I f you are living with HIV and you do get T.B, you can still cure the T. B by taking treatment. - T. B are stigmatized because as HIV. - Increase awareness on a T.B / HIV within our selves and our surroundings. - Ensure going for the a T.B diagnosis / HIV /AIDS tested as we are all assumed positive until as a result T.B negative and HIV /AIDS

In the decades since antiretroviral therapy became the standard of care for HIV, it has transformed quality of life for people living with the virus. The life-saving therapy—a combination of many medicines—prevents development of AIDS, improves immune function, and markedly lowers the risk of transmitting the virus to others. However, antiretroviral therapy is far from an HIV cure, says Gladstone virologist Melanie Ott. People who take the therapy still deal with chronic inflammation due to ongoing activation of the immune system, which can cause a host of other health problems—including higher rates of heart disease and certain cancers. And, if treatment is interrupted for even a short time, the virus bounces back. The reason for this, Ott says, is that the drugs that make up today’s antiretroviral therapy don’t completely block all lingering HIV cells in the body from being active, nor do they eliminate these infected cells. In a commentary article now appearing in the journal Nature Microbiology, Ott and her collaborators make the case for prioritizing a new type of medicine that can be added to current antiretroviral therapy to silence the so-called “transcriptionally active” infected cells of the HIV reservoir. Read more: https://bit.ly/3NnPYGW