Christoph Nabholz的动态

Fascinating paper out today on the possibility of quantifying and predicting common age-related diseases in adults. They showed that plasma proteomics may be a reliable tool to identify biological mechanisms involved in disease. These can then serve as useful tools for identifying possible drug-able targets or lifestyle modifications to reduce premature mortality and reduce/delay the onset of major age-related diseases and morbidities. https://lnkd.in/gdEJv4A8

Blood ‘clock’ predicts chronic disease risk An age ‘clock’ based on around 200 proteins in the blood can predict a person’s risk of developing chronic disease. Researchers developed the clock with data from more than 45,000 people in the UK Biobank. The protein clock attempted to predict each person’s chronological age. If the prediction was higher than a person’s real age, that person was more likely to develop at least one of 18 chronic diseases including diabetes, Alzheimer’s and cancer. ‘Slow agers’ – people whose protein clocks seemed younger than their actual age — were far less likely to develop these conditions. #chronicdisease #diseaserisk #bloodproteins #biobank #lackofdiversity #research #health https://lnkd.in/d4VYc5Ue

?? Researchers have built a ‘proteomic age clock’ that can predict your biological age and the likelihood of developing 18 age-related diseases, including cancers. By analyzing the levels of 204 #proteins in the blood, this clock offers new insights into #aging and health risks.? Read more: https://lnkd.in/g_it7z5D #Proteomics #Insight #PrecisionMedicine #BGIGeneTest

Exciting Breakthrough in Disease Prediction - The Protein Clock: Researchers have developed a "protein clock" that can predict a person’s risk of developing 18 chronic illnesses, including Alzheimer's, heart disease, cancer, and diabetes, by analyzing the levels of roughly 200 proteins in the blood. The clock, which accurately reflects biological age and disease status, was nearly as effective using only 20 key proteins. The study highlights the potential for this clock to enable early detection and prevention of age-related conditions, offering a new approach to personalized healthcare. Researchers are now working to expand the study to include more diverse populations and explore how environmental and behavioral factors influence protein aging. https://lnkd.in/eNd3iZWS

Recent research has developed a proteomic age clock, offering new insights into how biological aging impacts chronic diseases, including lung conditions in the elderly. By identifying key proteins that predict disease risk, this study underscores the critical role of research and innovation in combating age-related health issues. As we continue to explore the biological markers of aging, the collaboration between researchers and industry will be essential in developing novel strategies to prevent and treat chronic diseases, improving the quality of life for aging populations. #Aging #Proteomics #LungHealth #Innovation #Collaboration https://lnkd.in/gbkBmQ6Z

A recent study may have uncovered why autoimmune diseases affect women so much more than men. Researchers found that an RNA molecule called Xist—responsible for “quieting” one of women’s two X chromosomes—might accidentally trigger immune responses, putting women at higher risk. This could be a game-changer in understanding (and eventually treating) autoimmune diseases. This discovery is a reminder of how essential gender-focused research is to unlocking better treatments for everyone. ??? https://lnkd.in/dmrr5bdd #AutoimmuneAwareness #womenshealth #MedicalBreakthrough

In a groundbreaking study supported by the NIH and reported in the journal Cell, researchers from Stanford University School of Medicine have uncovered a potential reason why autoimmune diseases are significantly more common in women than in men. The answer might lie within our chromosomes, specifically the X chromosome. Women possess two X chromosomes, unlike men, who have one X and one Y chromosome. This biological difference could be vital to understanding the prevalence of autoimmune diseases among women. The study focuses on molecules known as Xist, crucial for X-chromosome inactivation, which prevents females from producing excessive proteins. However, these molecules can also form problematic clumps that may trigger autoimmune responses. This phenomenon could explain why diseases like rheumatoid arthritis and lupus are up to four times more common in women. Interestingly, when male mice were genetically modified to produce Xist, they exhibited increased susceptibility to a lupus-like condition, highlighting the potential role of Xist in autoimmune diseases. Additionally, blood samples from people with autoimmune conditions revealed antibodies to their Xist complexes, suggesting these could serve as markers for early detection of autoimmune diseases. This research opens up new avenues for understanding and potentially diagnosing autoimmune conditions earlier. Meanwhile, women grappling with these challenging diseases can find support through health and wellness coaching. Coaches can offer mental, physical, and spiritual guidance, helping women navigate the complexities of their conditions by fostering resilience, managing stress, and advocating for healthy lifestyle choices. As the scientific community continues to unravel the mysteries of autoimmune diseases, health and wellness coaching provides immediate support, empowering women to lead fuller, healthier lives despite their diagnoses. Reference: Bertagnolli, Dr. M. (2024). Study offers new clues to why most people with autoimmune diseases are women. National Institutes of Health. https://lnkd.in/eX2C5JcC #AutoimmuneDiseases #WomensHealth #XChromosome #HealthCoaching #Wellness #AutoimmunityResearch #ChronicIllnessSupport #NIH

Multiomics has shown promise in noninvasive risk profiling and early detection of various common diseases. In the present study, in a prospective population-based cohort with ~18?years of e-health record follow-up, we investigated the incremental and combined value of genomic and gut metagenomic risk assessment compared with conventional risk factors for predicting incident coronary artery disease (CAD), type 2 diabetes (T2D), Alzheimer disease and prostate cancer p/b UC San Diego, Wellcome Genome Campus, University of Cambridge, Michael Inouye, Baker Heart and Diabetes Institute, Baker Heart and Diabetes Institute, University of Melbourne, Finnish Institute for Health and Welfare (THL), Matti Ruuskanen, Oleg Kambur,?Pekka Jousilahti,?Aki S. Havulinna, Turun yliopisto - University of Turku, Matti Ruuskanen, Leo Lahti, Arizona State University, Qiyun Zhu, Cornell University, Qiyun Zhu, Yoshiki Vazquez-Baeza, RMIT University, Karin Verspoor (FAIDH), Teemu Niiranen, Aki S. Havulinna, Monash University, Guillaume Méric, La Trobe University, Guillaume Méric, Uppsala universitet (Uppsala University), The Alan Turing Institute #microbiome #diabetes #multiomics https://lnkd.in/gA69yY9b

We are hosts to Trillions of microbes! Neurxstem's CEO ponders the slew of credible papers that implicate microbes causing Alzheimer's and Parkinson's diseases! ??♂? This was first noticed in autism spectrum disorders! The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders https://lnkd.in/evS-t3pk Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer’s disease https://lnkd.in/ee6jZ43k Genetic correlations between Alzheimer’s disease and gut microbiome genera https://lnkd.in/d652aj7d Virus exposure and neurodegenerative disease risk across national biobanks https://lnkd.in/ea6Gmyw4 Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics https://lnkd.in/eF6qZm3N Gut Microbial Metabolites in Parkinson's Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment https://lnkd.in/e-js7AVc #neurodegeneration #microbes #gut #Alzheimers #Parkinsons #virus #bacteria #microbiota #aging #autism #enviroment #climatechange

Scientists Find a Major Clue Why 4 of 5 Autoimmune Patients Are Women Stanford researchers may have cracked the mystery of why women suffer far more autoimmune diseases than men. ?? A new study in the journal Cell introduces the X chromosome as a factor underlying female risk. ?? The process of X-chromosome inactivation produces unusual RNA-protein complexes that appear foreign to the immune system, potentially triggering autoimmunity. A key quote from the study, that illustrates why funding more research on women's health is critically important: "Every cell in a woman’s body produces Xist. But for several decades, we’ve used a male cell line as the standard of reference. That male cell line produced no Xist and no Xist/protein/DNA complexes, nor have other cells used since for the test. So, all of a female patient’s anti-Xist-complex antibodies — a huge source of women’s autoimmune susceptibility — go unseen." ?? Let us hope this breakthrough discovery can help researchers predict and treat these baffling conditions. ??? ?? #HealthcareonLinkedIn #womenshealth