CellSave Arabia的动态

Microgravity environments (like the International Space Station) are great for running scientific experiments and technology demonstrations… ?? ESA’s CASE (Commercial Applications enabled by Space Environments) initiative allows companies to study products/services that may benefit from validation (or development) in a space environment before commercialisation on Earth, for example: ? Astrobone - Osteoporosis is a chronic health condition that weakens bones and increases risk of fracture. Bone loss occurs rapidly in microgravity because weightlessness unloads the skeleton and triggers physiological changes in the body. Thus making microgravity environments a good candidate for testing new therapeutics for osteoporosis patients on Earth. Astrobone investigated interactions of human bone cells with a resorbable bone scaffold to derive insights into bone regeneration in osteoporotic conditions: https://lnkd.in/euB5NFyW ?? Microgravity for Personalised Medicine (M4PM) - 3D cell culture in vitro systems offer advantages over both 2D cell models and in vivo animal models in the study of physiological and pathological processes, as well as pharmacological responses. M4PM assessed the potential of microgravity environments to enable the development of higher-quality 3D tumours, organoids, and spheroids compared to what is achievable on Earth. This in view of improving drug research, disease modelling, and related fields: https://lnkd.in/ejg4G99g Other ideas for commercial microgravity applications? Check out CASE: https://lnkd.in/ekAdwpH3 #microgravity #internationalspacestation #spaceapplications #spacetechnology #medicine #spaceenvironment Image credit: NASA Johnson

A series of Space Bioengineering: #1 in Nature https://lnkd.in/gHpfwaX4

I recently had the incredible opportunity to visit Dr. Hiromitsu Nakauchi Hiro’ lab at Stanford University where I met with Joydeep Bhadury, whom I first connected with at SynBioBeta conference and his colleague Fabian Suchy. Our discussions quickly dove into some of the most cutting-edge topics around in-space manufacturing for stem cells and organ preservation—areas crucial for the future of long-duration spaceflight. The Nakauchi Lab is truly at the forefront of stem cell therapy and organ transplantation research. They have pioneered the expansion of hematopoietic stem cells (HSCs) for both mouse and human models, and their work on extending the viability of pluripotent stem cells (PSCs) and embryos through organ pausing techniques is groundbreaking. Their methods have shown promising results in preclinical models, significantly expanding the preservation windows for organs like the heart, liver, and lungs. This kind of innovative research has direct applications to space exploration, where slowing metabolism and vital functions—mimicking natural states like torpor—could prove to be game-changers for long-duration missions. I’m excited about the potential collaboration between our efforts at BioServe Space Technologies University of Colorado Boulder with our new stem cell expansion space facility funded by the NASA - National Aeronautics and Space Administration In-Space Production Applications, my work at NASA Ames Research Center on space life sciences, and the Nakauchi Lab in leveraging these advancements for in-space manufacturing and preserving human health during space travel. #StemCellResearch #InSpaceManufacturing #OrganPreservation #SpaceHealth #BioServeSpaceTechnologies #NakauchiLab #SpaceExploration

What an enthralling day filled with discovery! I had the privilege of visiting Geneva to delve into the fascinating world of CERN, the renowned institution probing the most fundamental particles and laws of the universe. While the origins of the Big Bang remain elusive, the researchers at CERN are steadily advancing our understanding. CERN's contributions to humanity are monumental. Thanks to their groundbreaking work, we've witnessed the birth of the World Wide Web, PET technology, touch screens, and even the first 3D color X-ray images of the human body. My focus during the visit was on #nuclear #medicine and the pivotal role of #radioisotopes, which save millions of lives annually. These isotopes are indispensable for diagnostic imaging across various health conditions and for combating #cancer through specific treatments. The concept of using radioisotopes to fight cancer isn't new; Marie Sklodowska-Curie herself advocated for radium's potential as a cure in a 1921 article for The New York Times. I owe a debt of gratitude to Thierry Stora for introducing me to CERN-Medicis, a facility dedicated to researching medical radionuclides and pioneering mass separation techniques. I also extend my thanks to Laura Lambert for generously allowing me to witness the intricate process of radioisotope production in her laboratory. From target preparation to irradiation and separation, each step was a testament to human ingenuity. Additionally, Sven de Man's insights into robotic handling techniques for maintaining safety and preventing contamination were eye-opening. Radioisotopes, whether naturally occurring or manmade, play a vital role in modern medicine. While they offer immense therapeutic potential, their short half-lives present logistical challenges in the supply chain. This underscores the importance of on-site production facilities like those at HUG - Hopital Universitaire de Genève, where accelerator expedites the delivery of molecular medicine and imaging services to patients. The field of nuclear medicine is evolving rapidly to meet growing demand. HUG's introduction of targeted radionuclide therapies to patients in 2023 is a testament to this progress, promising improved outcomes with fewer side effects. As articulated by Professor Valentina GARIBOTTO, while molecular medicine continues to advance, it's not without its challenges. Regulatory, technical, political, and financial obstacles hinder the seamless flow of radioisotopes through the supply chain. Philippe C. and I are collaborating on an European Economic and Social Committee opinion to highlight these challenges and propose solutions. Despite Europe's leading position in radioisotope production, it remains vulnerable to dependencies on third countries for essential materials and processing operations. It's imperative that EU Member States prioritize the reinforcement of Europe's capacities to ensure the security of radioisotope supplies for medical purposes.

Research from Aerospace & Mechanical Engineering at Notre Dame is literally taking off. An experimental cancer study led by Assistant Professor Meenal Datta will unfold at the International Space Station over the next 30 days. At 250 miles above Earth’s surface, a unique microgravity environment can shed light on the immune response to glioblastoma. “When it comes to advancing health research, there are many things we can do more efficiently in space than on the ground,” Datta, an affiliate of Notre Dame’s Harper Cancer Research Institute, said. “Space provides a better way to synthesize a reproducible model. And better models allow us to more quickly develop and test the treatments that can fight this cancer and ultimately save lives.” Though the self-contained experiment will reach the final frontier, research into tumor formation is far from over. That’s why Datta and Alice Burchett, a doctoral student in Notre Dame’s Bioengineering Graduate Program, will collect the samples and compare their development to similar structures grown on Earth. Datta is also an affiliate of the Eck Institute for Global Health at the University of Notre Dame, the Berthiaume Institute for Precision Health, Notre Dame Nanoscience & Technology (NDnano), the Warren Center for Drug Discovery, the Lucy Family Institute for Data & Society and the Boler-Parseghian Center for Rare and Neglected Diseases at the University of Notre Dame. Learn more about the voyage, and about how you can tune in to the liftoff: https://lnkd.in/e3hNUbPy

Thrilled to share our recently published article in the SPIE, the international society for optics and photonics (#spie2024) proceedings! ?? Advancing in vitro virtual nuclei staining of stem cells through a cross-structure, artifact-free U-Net approach ?? Introduced an advanced deep learning model, AFU-Net, revolutionizing the analysis of stem cell images by significantly reducing artifacts common in bright-field imaging. ?? Achieved unparalleled precision in stem cell segmentation, with the AFU-Net outperforming existing models using key metrics like Segmentation Covering (SC) and Variation of Information (VI), indicating a significant leap in efficiency and accuracy in high-throughput stem cell analysis. If you have any insights or questions – feel free to reach out! #spie #celltherapy #biotechnology #research #innovation #networking #msca #ai #medicalimaging

Cell culture happens in space, too! ?? ???? Researchers from?Stanford University?&?Cedars-Sinai?took induced pluripotent stem cells to the?International Space Station National Laboratory?to study the effects of spaceflight (and microgravity) on the human heart ??. According to?Arun Sharma, PhD, "???? ???????? ?????????????? ?????????????????????? ???????? ?????????? - ?????????? ?????????? ???????? ???????? ???????? ???????????????????????? - ?????? ???????????? ???????? ???????? ?????????????? ?????????? ?????????? ??????????. ?????? ????'???? ???????????? ???? ?????? ?????????? ?????????? ???? ?????????????? ????????'?? ?????????? ???? ???????????? ???? ?? ???????? ?????????????? ???? ?? ???????????? ?????? ?????? ?????????? ??????????????." Read about it here!?https://lnkd.in/gqu79Cjg #heartdisease #cellculture #stem #scienceinspace #biology #biotech

Did you hear about MicroQuin's project aboard the #ISS? #5 Space and Pharma Success Stories MicroQuin's microgravity experiment grows BI-1 crystals (a crucial drug target with implications for treating various diseases including #cancer), unlocking crucial insights into its structure and paving the path for #advancements in therapeutics. Here's the scoop: BI-1 has been difficult to study on Earth due to challenges in expressing and purifying it. But in the #microgravity environment of the ISS, MicroQuin has achieved something remarkable. By growing crystals of BI-1 in #microgravity, they've obtained invaluable insights into its structure. These crystals could hold the key to developing new #therapeutics that combat diseases more effectively than ever before. "We got some amazing crystals on the #ISS, which we utilised for structural analysis. BI-1 structure will increase our ability to make therapeutics to combat the world’s top diseases” says Scott Robinson, PhD, CQF, Microquin. Imagine the possibilities: targeted treatments for #cancer, #liverdiseases, #autoimmunedisorders, and more, all inspired by research conducted in space. MicroQuin's work opens doors to a future where #diseases are tackled with precision. Stay tuned for updates as they continue their journey of #discovery among the stars! Read More:?https://lnkd.in/gdV6dNma #drugdiscovery #cancerresearch #microgravity #proteincrystallisation #ISS?

NASA Station Science Highlights: November 8, 2024 Breakthrough in 3D Bioprinting in Microgravity In an impressive stride forward, researchers have successfully demonstrated the viability of 3D bioprinting knee cartilage, or meniscus tissue, under microgravity conditions. This achievement marks a significant advancement in the technology of bioprinting tissue, offering promising solutions for treating musculoskeletal injuries during extended space missions or in extraterrestrial environments where resources and supplies are constrained. The research, known as the BFF Meniscus-2 project, utilized the BioFabrication Facility to 3D print knee cartilage tissue using bioinks and cells. This effort has resulted in the creation of the first engineered tissue of anatomically relevant shape on […] https://lnkd.in/ddZDSKen https://lnkd.in/dY4PrKXf