CellarisBio的动态

DNA-encoded libraries (DELs) are a technology that allows for the rapid screening of large collections of small molecules against a target protein. How it works: DELs are made by attaching a unique DNA barcode to each compound in a library of chemical building blocks. The DNA barcode serves as an amplifiable tag that allows for the identification of specific compounds in a complex mixture. Benefits: DELs can be used to screen billions of compounds at once, which is much faster and cheaper than traditional methods. This allows for the discovery of new molecular compounds, or "hits", that could be used in drug development. Applications: DELs are a powerful tool in the pharmaceutical industry and in academia. They are used to identify new ligands for both novel and traditional biological targets. Cellular DEL is an application MICRO-TAG system enables -- it enables discovery of ligands under cellular conditions. This particularly works well for challenging drug targets.