BioCardia, Inc.的动态

Want to learn how to standardize variant interpretation? Join Labroots at the 2024 Precision Medicine Virtual Event for the panel presentation titled, “Mitigating Variability in Somatic Variant Interpretation with Live Q&A” on May 15 at 10:30 AM PDT. In this live panel discussion, experts in NGS testing and clinical informatics will explore the issues surrounding the standardization of variant interpretation and consider how interpretation guidelines and clinical decision support (CDS) software can help to mitigate variability between laboratories. Register now to learn more: https://buff.ly/3TYPbjU #LRprecisionmed

Don’t miss out on trying our new Self-Amplifying RNA production service with tailored design and modifications, delivered in as fast as 2 weeks, for your project. Learn more here: https://ow.ly/e85B50RfRA4 #mRNA #saRNA #researchprojects #genesynthesis #biotechservice #biologyresearch #molecularbiology

Adding ribosomal RNA depletion into your #sequencing workflow reduces the number of uninformative reads for improved data quality. Read this application note to learn the advantages of two #rRNAdepletion methods when used with Agilent Technologies SureSelect XT HS2 RNA #librarypreparation. https://bit.ly/4bwaK1f

Designing LNPs for RNA delivery? Check out this great manuscript from Jake Brenner's team from the University of Pennsylvania on bioRxiv. This pre-print (https://lnkd.in/dpDZ3riu) describes how LNP design can attenuate LNP-associated inflammation caused by "excessive" endosomal membrane damage leading to inflammatory responses (the "endosomal escape" is a double-edged sword). Certain LNPs containing rapidly biodegradable ionizable lipids have the potential to rather induce membrane damage that can be repaired by the endosomal sorting complex required for transport (ESCRT), which leads to safer LNPs. Looking forward to seeing this published soon, well done Serena Omo-Lamai et al.

An interesting article showing the progress being made in advancing molecular glues and heterobifunctional degraders into the clinic and closer to approval. #TPD #degraders #molecularglue

Come and join us for our talk in Harvard Medical School. Single cell multi-omics analysis is unlocked right here and right now by Mirxes Genomics!

Recent research has introduced new treatments and diagnostic tools, showing promising results, including #Leqembi (Lecanemab), #Simufilam, #AR1001 and many others. These advancements bring new hope for AD patients, although clinical application still faces challenges. Learn more about these advancements in AD treatment and diagnosis ?? https://bit.ly/3XwlxVv #AlzheimersDisease #NeurodegenerativeDiseases #HealthcareInnovation #ADResearch #Biotech #MedicalResearch

2025 - The Year of Omics Boom? in 2023. Eric Sharma and I sat in our office in High Wycombe, UK and discussed the state of the Omics market. The pros, cons & challenges that surrounded the name. On our initial plan, we associated 2025 with 'The Year of Omics Boom' This referred to many things, included our sales performance, technological market adoption & us growing Zenopa to the gold standard search and selection company within Omics globally. Reading the below article is one of the moments we waited for. The Moment 'Multi Omics' becomes mainstream in laboratories & hospital settings on a global basis. This article highlights the potential of multi-omics in advancing our understanding of biology and improving healthcare, while also emphasising the need for continued technological and infrastructural development to fully realise its benefits.

?? Exciting News! Check out our latest App Note showcasing Microfluidic Modulation Spectroscopy (MMS) for RNA structural characterization! ?? MMS is revolutionizing RNA research, offering unparalleled insights into RNA structural changes crucial for therapeutic development. Our study delves deep into the regulatory roles of RNA molecules, spotlighting riboswitches and their response to small molecule ligands. Understanding the dynamic interplay between RNA and ligands is pivotal across various biological contexts. We zoom in on the SAM-I riboswitch, illustrating its significance as a prime example. Download now to uncover the intricate world of RNA structural dynamics! #RNA #rnatherapeutics #innovation #spectroscopy #riboswitch #ligandbinding #biopharma #drugdiscovery

How dexamethasone protects against severe COVID-19 Dexamethasone was used as an effective drug for severe COVID cases during the pandemic. A study integrating single-cell and bulk transcriptomics in clinical cohorts reveals the molecular basis of its immunomodulatory effect and also provides a framework for the future development of companion diagnostics for patient stratification in precision medicine. The authors show that dexamethasone-induced transcriptional changes were confined to a specific monocyte state and molecular treatment responses in monocytes were directly linked to clinical outcome. They also found that reversal of dysregulated monocyte signatures in dexamethasone-treated COVID-19 survivors and monocyte single-cell signatures stratified blood samples could be used for treatment response. #sciencenewshighlights #ScienceMission https://lnkd.in/gbhz_5rp https://lnkd.in/gpMi5dY6