Agilent Pharma - Small Molecule and Biologics的动态

Discover what's new in Therapeutic Oligonucleotides & Chromatography with Patrick Endres’s talk at 2:45 PM, part of IOPC 2024! Plus, don't forget to view Dr. Elena Kumm’s poster: Purification of a 100 Nucleotide ssDNA Oligomer using Anion Exchange Chromatography. Agenda available here: https://bit.ly/3VVSREd ? #ChromatographyExperts #Oligonucleotides #IOPC2024

Separation of the final oligonucleotide product from its closest impurity is challenging, as these impurities are highly related to the full-length product. Download resource guide to see the Agilent complete workflows for oligonucleotide analysis to help you achieve accuracy and optimize speed. https://bit.ly/3TglsBD #oligonucleotidepurity #oligopurity #oligoimpurity

Read Our Case Study Here: https://hubs.li/Q02VM5tm0 Tired of slow, resource-heavy polymorph screening that delays your drug development? When tight timelines and limited material availability are at stake, traditional methods often fall short—leading to costly delays. The XtalPi team was tasked with analyzing two similar Remdesivir anhydrates and utilized a combined experimental and computational approach to quickly identify the most stable polymorph for reliable drug product development. Here's how we delivered results 2x faster than standard polymorph research: ? Utilized MicroED to identify the crystal structures of Form II and, for the first time, of Form IV, explaining their similar XRPD patterns and properties. ? Leveraged AI-powered Crystal Structure Prediction (CSP) to predict and recommend Form II as the most stable anhydrate at room and high temperatures, well ahead of traditional timelines.? #MicroED #crystalstructureprediction #drugdevelopment

Chrys Kokino, Accord US President, sat down with Citeline Commercial's Generics Bulletin to discuss our approach to US #biosimilars. Dive into the first of a two-part series and read the full interview here: https://bit.ly/4cgDIn8

Enclosing?hydrazine?into a cycle creates?aza-analogues of piperidines, pyrrolidines, and azepines. These structures can enhance molecular polarity, provide accessible sites for chemical functionalization, and allow for fine-tuning of structural and electronic properties?of biomolecules. For example, RMC-9805, a KRAS G12D inhibitor, contains a piperazic acid moiety and has recently entered Phase 1 clinical trials. Enamine offers a collection of cyclic and bicyclic saturated hydrazine structures: https://bit.ly/4ey7DI3 Try our cyclic hydrazines in your research!

To wrap-up on our latest posts on intestinal permeation enhancement, find more information on the mechanisms that lay behind it in our article: https://lnkd.in/d2nuMTCf In this hot topic, learn about the functions and characteristics of the intestinal epithelium, and how the Gattefossé permeation enhancers can be used to facilitate the absorption of small or large molecules. #gattefossé #pharmaceuticals #intestinalpermeation

The new degron system described in the article offers a promising avenue for target validation studies, especially for proteins of interest (POIs) lacking small molecule ligands. Its small size reduces the likelihood of independent ubiquitination and degradation, unlike larger tags, enhancing its suitability for evaluating POI degradability. doi: https://doi.org 10.1101/2024.03.15.585309 #protac #molecularglues #drugdiscovery

Simplify method development when scaling up from analytical to purification with the AdvanceBio Oligonucleotide scalar, semi-prep and preparative dimensions and achieve high yield purification. https://bit.ly/3VafVyE #AdvanceBio #oligonucleotide

Time is running out! Register for our webinar now ?? ? Join us as we welcome our fourth speaker Karl Box, Chief Scientific Officer – Pion Europe, who will present on "Using Flux Tools to Demonstrate the Impact of the Particle Drift Effect on Oral Drug Absorption". ? About this presentation: The “Particle Drift Effect” has been used as an explanation for the discrepancy between experimental fraction absorbed (FA%) observations in-vivo and theoretical predictions, observed when increasing the API dose beyond intestinal fluid solubility limitations. ? In this presentation, we will describe the use of Pion’s μFlux apparatus for capturing flux data in the presence of excess solids and illustrate how in-vitro flux measurements can be used to assess the FA% outcome, for solubility-limited oral absorption cases. ? Join us to learn more and secure your spot by registering today! https://lnkd.in/e6XVcp5C #particledrift #oraldrug #intestinaldrugabsoption #colloids #nanoparticles #Pion #invivo #solubility #invitro

Paclitaxel is a well-known anticancer compound. Its biosynthesis involves the formation of a highly functionalized diterpenoid core skeleton (baccatin III) and the subsequent assembly of a phenylisoserinoyl side chain. Despite intensive investigation for half a century, the complete biosynthetic pathway of baccatin III remains unknown. Here, Lei et al. identified a bifunctional cytochrome P450 enzyme (Taxane oxetanase, TOT) that catalyzes an oxidative rearrangement in paclitaxel oxetane formation, representing a previously unknown enzyme mechanism for oxetane ring formation. The researchers created a screening strategy based on the taxusin biosynthesis pathway and uncovered the enzyme responsible for the taxane oxidation of the C9-position (T9αH). Finally, the researchers artificially reconstituted a biosynthetic pathway for the production of baccatin III in tobacco.