Big congratulations to iGEM Aachen team 2024 for their outstanding performance at iGEM Competition for their gold medal on the Runner-up prize, "Best Oncology Project”, “Best Education” and “Best Hardware” awards!!!
Wir sind sehr stolz auf Sie!! https://lnkd.in/dxjwQ9MF
Project: OncoBiotica - Microbiota-Directed Cancer Therapy
https://lnkd.in/dCrDGfBq
Description: Cancer remains a global health crisis, with over 10 million lives lost in 2020 alone. OncoBiotica introduces an innovative approach to precision oncology by targeting tumor-associated microbes, offering an alternative to conventional cancer therapies that focus on cancer cell biomarkers. Our two-phase mechanism leverages a fusion protein to bind tumor-specific microbes and activate a prodrug, transforming it into a chemotherapeutic agent directly at the tumor site. To validate this, we used colorectal cancer and Fusobacterium nucleatum as our model system. Through collaborative efforts, including expert consultations, lab research, and hardware development, we successfully engineered a functional fusion protein, refined it through mutant variants, and developed MAIK, a cost-effective system for drug testing. Additionally, our education platform, AlphaFold Decoded, fosters understanding of AI in structural biology, empowering the next generation of scientists. With modularity, scalability, and global accessibility at its core, OncoBiotica offers a promising future for personalized cancer treatment.
Congratulations to the 2024 iGEM Grand Prize and Runner-up Prize Winners ??
These teams pushed the boundaries of synthetic biology by tackling everyday issues facing the world. We wish you all the best and can't wait to see you what you do next!
https://lnkd.in/dZxmsEpZ