Academy of Clinical and Dental Genetics (Online) 的动态

#SmartMaterials #Applications Intelligent materials are advanced materials that can respond to external stimuli, such as temperature, pH, light, mechanical forces, or electrical fields, and change their properties or behavior in a controlled and predictable manner. These materials can be designed to "sense" changes in their environment and act accordingly, making them highly suitable for applications in the biomedical sector. Applications of Intelligent Materials in the Biomedical Sector: 1. Smart Drug Delivery Systems: Intelligent materials can be engineered to release drugs in response to environmental changes such as pH, temperature, or specific enzymes. Example: Hydrogels that swell or shrink in response to changes in pH, allowing for the controlled release of therapeutic agents, particularly for targeted cancer treatments. 2. Tissue Engineering and Regenerative Medicine: These materials can provide scaffolds for cell growth that change properties to promote tissue repair. They can respond to biochemical signals and mechanical forces to guide cell behavior, aiding in tissue regeneration. Example: Shape-memory polymers that can be used as scaffolds that expand or contract in response to environmental cues to help with wound healing or organ regeneration. 3. Biosensors: Intelligent materials can be used in biosensors to detect specific biological markers in real time, offering diagnostics for diseases like cancer, diabetes, or infections. Example: Materials that change color or fluorescence in response to the presence of certain biomolecules, enabling rapid detection of disease markers. 4. Biomedical Implants: Smart materials can be used to create implants that adapt to the body’s environment, improving comfort and functionality. For example, materials that change stiffness in response to surrounding tissue growth or mechanical forces. Example: Self-healing materials for implants or prosthetics that can repair themselves if damaged, extending their lifespan. 5. Wound Healing: Intelligent materials can be used in wound dressings that change in response to infection or the healing stage of the wound, allowing for a more efficient healing process. Example: Hydrogels or materials that respond to moisture levels or pH to promote healing and prevent infections. Types of Intelligent Materials in Biomedical : 1. Shape-memory materials: These can "remember" a predefined shape and revert to it when triggered by external stimuli (e.g.temperature or light). Useful for stents, surgical tools, and tissue engineering scaffolds. 2. Hydrogels: These are water-absorbent materials that can change volume or mechanical properties in response to external stimuli. They are often used in drug delivery and wound healing. Future Prospects: The ongoing development of intelligent materials in the biomedical sector promises more personalized, effective, and efficient healthcare solutions. With advancements in nanotechnology, biotechnology, and materials science.

"The Science of ?????????????? ????????????????: Enhancing Human Health through Technology" ? ? ?????????? ???????? ???? ?????? ??????: https://lnkd.in/dwntEYmn ? The growth of #medicalceramics can be primarily attributed to the growing utilization of active implantable devices, the rising adoption of ceramics in drug delivery, the high acceptance of ceramics in dental and #orthopedic implants, the rising demand for bio-ceramics in cosmetic dentistry, and the increasing demand for custom engineered medical implants. Moreover, emerging economies and technological advancements in ceramics, such as high heat-compatible ceramics, chemical-resistant ceramics, complex geometric medical ceramics, and #technicalceramics, are expected to offer growth opportunities for the players operating in this market. ? The use of medical ceramics in cancer #diagnostics and treatment has shown positive results and is a growing area of interest. Currently, cancer is treated through surgical procedures wherein the tumor is removed, followed by #radiotherapy and/or #chemotherapy to ensure that the remaining microscopic bits of cancer are destroyed. However, the side effects of chemotherapy can damage healthy cells, cause infections, and weaken the #immunesystem. ? ? ??????????????: ??????????1.?Growing Utilization of Active #ImplantableDevices ?????????2.?Rising Adoption of #Ceramics in Drug Delivery ?????????3. High Acceptance of Ceramics in #Dental and Orthopedic Implants ?????????4.?Rising Demand for Bio-ceramics in #CosmeticDentistry ? ? ?????? ??????????????: 3M DePuy Synthes CoorsTek, Inc. KYOCERA Global Institut Straumann AG Morgan Advanced Materials Materion Corporation ? #Bioceramics #HealthcareInnovation #AdvancedMaterials #MedicalTechnology #CeramicImplants #BiomedicalEngineering #CeramicProsthetics #BioMaterials #MedTech #Biocompatible #HealthTech #MedicalDevices #CeramicScience #OrthopedicImplants #DentalCeramics #CeramicResearch #Nanoceramics #MedicalInnovation #CeramicEngineering

"The Science of ?????????????? ????????????????: Enhancing Human Health through Technology" ? ? ?????????? ???????? ???? ?????? ??????: https://lnkd.in/dXtug2AU ? The growth of #medicalceramics can be primarily attributed to the growing utilization of active implantable devices, the rising adoption of ceramics in drug delivery, the high acceptance of ceramics in dental and #orthopedic implants, the rising demand for bio-ceramics in cosmetic dentistry, and the increasing demand for custom engineered medical implants. Moreover, emerging economies and technological advancements in ceramics, such as high heat-compatible ceramics, chemical-resistant ceramics, complex geometric medical ceramics, and #technicalceramics, are expected to offer growth opportunities for the players operating in this market. ? The use of medical ceramics in cancer #diagnostics and treatment has shown positive results and is a growing area of interest. Currently, cancer is treated through surgical procedures wherein the tumor is removed, followed by #radiotherapy and/or #chemotherapy to ensure that the remaining microscopic bits of cancer are destroyed. However, the side effects of chemotherapy can damage healthy cells, cause infections, and weaken the #immunesystem. ? ? ??????????????: ??????????1.?Growing Utilization of Active #ImplantableDevices ?????????2.?Rising Adoption of #Ceramics in Drug Delivery ?????????3. High Acceptance of Ceramics in #Dental and Orthopedic Implants ?????????4.?Rising Demand for Bio-ceramics in #CosmeticDentistry ? ? ?????? ??????????????: 3M DePuy Synthes CoorsTek, Inc. CeramTec – The Ceramic Experts KYOCERA Global Institut Straumann AG Morgan Advanced Materials APC International Materion Corporation ? #Bioceramics #HealthcareInnovation #AdvancedMaterials #MedicalTechnology #CeramicImplants #BiomedicalEngineering #CeramicProsthetics #BioMaterials #MedTech #Biocompatible #HealthTech #MedicalDevices #CeramicScience #OrthopedicImplants #DentalCeramics #CeramicResearch #Nanoceramics #MedicalInnovation #CeramicEngineering

The concept ‘Biomaterial’ is fairly frequently encountered these days. Associated with advanced medical solutions and replacement of body parts, it has a slight futuristic nuance to it. But what is a biomaterial? And where and why is this material used? Contrary to what the word may implicate, a biomaterial is not necessarily biological or based on bio-related matter. The material itself can be anything from a metal to a plastic to varieties of composites, but it can also be bio-inspired and derived from nature. The definition of a biomaterial is a material that is designed with the purpose to interact with the body, i.e. it is designed to reside in a biological environment. Where and why are biomaterials used? Typically, the purpose of a biomaterial is to replace a missing piece of a body part, by replicating the structure that is no longer there, or to enhance function. Think of implants, such as hip joints, and heart valves, skin transplants, vascular grafts, and stents. Biomaterials are also used in less intrusive contexts, such as in contact lenses and wound care Although the biomaterial concept has a futuristic nuance to it, the desire and urge to mend a broken body is ancient. Attempts to replace or fix damaged or diseased body parts has existed for thousands of years. There are recordings of dental implants already from the Mayan era, where the tooth implants were made of nacre from seashells. Throughout history, there are plenty of recordings of foreign material being more or less successfully introduced into the body. We have carbon particle-based tattoos, sutures made of catgut and heads of biting ants, glass eyes, and stainless-steel hips to name but a few. The scientific area of biomaterials science as we know it today, however, is relatively new. It started around the 60s. At this time, we went from using the materials we had at our disposal to engineer materials with the intent of increasing the material integration success rate, and the area of biomaterial science was born. The concept of biocompatibility and functional materials In the old days, of course, the concept and understanding of biocompatibility did not exist. Most likely, it was mere luck if the implanted material was tolerated by the body, and the patient did not suffer from any severe side-effects. Today we have a good understanding of biocompatibility and tailor materials for desired interaction with the body. So, the material usage evolution has taken us from seashells in the Mayan period, to off-the-shelf materials such as polymers, metals, and ceramics after World War II, to engineered materials designed for biocompatibility in modern times. Here we find silicones, hydrogels, and hydroxyapatite, which today are commonly used. Now it is time for the next era. #Biomaterials #Biomedical #engineering #hospitals #healthcare #diagnosis #treatment #doctors #nurses #atheenapandian #succesfully

MEDICAL INNOVATION - Developing artificial skin that can regenerate skin and transmit sensation at the same time - Damage to nerve tissue due to skin defects such as burns, skin diseases, and trauma causes loss of sensory and cognitive functions that are essential for life-sustaining activities, as well as mental and physical distress. If the damage is severe enough that natural healing is not possible, surgical treatment is required to implant artificial skin in the affected area, but the artificial skin developed to date has focused on skin regeneration, providing a structure and environment similar to skin tissue, but has not restored sensation to patients. - The smart bionic artificial skin was implanted into rats with severe skin damage to test its effectiveness in promoting skin regeneration and reestablishing tactile function, and it showed a wound healing effect of more than 120% compared to the control group at 14 days after implantation. In addition, it detected external changes in the pressure range of 10 to 40 kPa, which is similar to the pressure range felt by human fingertips, and adjusted the electrical signals accordingly to change the rat's response. - More information:?Kyowon Kang et al, Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function,?Nature Communications?(2024).?DOI: 10.1038/s41467-023-44064-7 Provided by National Research Council of Science and Technology - https://lnkd.in/egbpuqUP

This Month’s 6 Health Tech Breakthroughs Restoring Human Abilities—and Paving the Way to Superhuman Potential >> ??Paralyzed patients regain mobility after brain electrode implants. Two individuals have been able to walk short distances and even climb stairs again, thanks to the implanted electrodes ?? Neuralink competitor Science Corporation is developing a biohybrid brain implant that uses living neurons to connect with the brain, offering greater precision and less damage than traditional implants. Early mouse trials are promising, though neuron survival and immune response remain challenges ??Scientists have developed bionic legs controlled by the brain, using innovative surgery that reconnects muscle pairs for natural movement,improved control and mobility ??Researchers are building a ‘bionic breast’ to revive feeling post-mastectomy and reconstruction. The first clinical trial of a key component is due to start early this year ???A new bioprinter, the first to print tissue directly onto wounds, speeds up 3D tissue printing by 10 times using cell clusters that mimic natural tissue. In tests, HITS-Bio repaired bone in a rat’s skull within six weeks ??By watching videos, surgical robots have learned to perform tasks like suturing and knot-tying with human-level precision, even correcting their own mistakes ??Links to all articles in comments below #DigitalHealth #HealthTech

Exploring the Future: The Uses of Bio-Printing in Medicine Bio-printing is revolutionising the field of medicine by offering innovative solutions to some of healthcare's most pressing challenges. At its core, bio-printing involves using 3D printing technology to create tissue and organ structures layer by layer, utilising bio-inks made from living cells. 1. Tissue Engineering and Regeneration: One of the most exciting applications of bio-printing is in creating complex tissue structures that can repair or replace damaged organs. Scientists are working on printing tissues like skin, cartilage, and even parts of organs like the liver. This advancement holds the potential to treat conditions ranging from burns to degenerative diseases. 2. Personalised Medicine: Bio-printing allows for the creation of customised tissue models that match a patient's unique genetic makeup. This personalisation helps in developing targeted treatments and drugs, reducing the risk of adverse reactions and improving the efficacy of therapies. 3. Drug Testing and Development: Traditional drug testing often involves animal models, which can be costly and ethically challenging. Bio-printed tissue models provide a more accurate and humane alternative for testing new drugs, allowing for better predictions of human responses and speeding up the drug development process. 4. Organ Transplantation: While we are still a way off from fully bio-printed organs, research is ongoing into creating scaffolds for organ transplantation. These scaffolds could eventually support the growth of a patient's cells, reducing the need for organ donors and the risk of rejection. 5. Surgical Training: Bio-printed models can be used to simulate human anatomy for surgical training and planning. Surgeons can practice these realistic models to refine their skills and prepare for complex procedures, leading to better outcomes in real-life operations. Bio-printing is pushing the boundaries of what's possible in medicine, offering hope for more effective treatments and personalised care. As technology advances, the dream of printing replacement organs and tissues may soon become a reality, transforming the landscape of healthcare as we know it. #bioprinting #healthtech #surgery

The Future of Dentistry: The Promise of Tooth Regeneration I’ve been closely following developments in regenerative medicine, and the progress in dental care is particularly exciting. Imagine a world where tooth loss is no longer a permanent problem – where we can regrow teeth through cutting-edge scientific breakthroughs. It's not science fiction; it's rapidly becoming a reality. I was particularly intrigued by the news that a drug designed to regenerate teeth is set to enter human trials at Kyoto University Hospital. This is a world-first trial following successful animal studies, and it marks a significant step toward a future free from tooth loss! Here's what this exciting development entails: - Deactivating USAG1:?The drug functions by deactivating a protein called USAG1, which naturally inhibits tooth growth. By blocking USAG1, the drug triggers the body to stimulate bone and tooth generation. - Human Trials Underway:?This human trial aims to assess the safety and effectiveness of the drug, and if successful, this therapy could be available within six years! But the innovation doesn't stop there. Scientists are exploring other approaches, including: 1- Dental Pulp Stem Cells:?Utilizing stem cells from within the tooth's pulp to regenerate dental tissues and structures. 2- Gene Therapy:?Manipulating genes involved in tooth development to activate dormant, tooth-forming cells. 3- 3D Bioprinting:?Using specialized 3D printing to create tooth-like structures with cells and growth factors. 4- Laser Technology:?Using low-power lasers to stimulate the body’s own stem cells to regenerate dentin, the main component of the teeth. The potential impact of this research is truly transformative. It promises: 1- Permanent Solutions:?Moving beyond temporary fixes like dentures, bridges, and implants to offer a permanent solution for tooth loss. Reduced Need for Invasive Procedures:?Offering less invasive alternatives to root canals, fillings, and other dental procedures. 2- A Future of Healthy Smiles:?Paving the way for a future where tooth decay and loss are no longer a lifelong burden. I’m sharing this because I'm always eager to explore emerging technologies and how they can reshape industries. #RegenerativeDentistry #ToothRegeneration #StemCellResearch #GeneTherapy #Bioprinting #Innovation #MedicalInnovation #Healthcare #FutureofHealthcare #Science #Research #Technology #Leadership #VisionaryLeadership #Hiring #Recruitment #ExecutiveSearch

The world’s first ??????????-???????????????????????? ???????? is here. Japanese firm Toregem Biopharma is set to begin trialing in September with plans to hit the market by 2030. Regenerative dentistry holds great promise for the future of dental care: Researchers at Karolinska Institutet have used single-cell RNA sequencing and genetic tracing to identify all cell populations in mouse and human teeth. Conventional treatments in endodontics and periodontics are being transformed through innovations such as pulp revascularization and guided tissue regeneration, enhanced by 3D bioprinting. Studies continue in the fight to increase the survival rate of compromised teeth both with molecular- and cellular-based techniques. As the research progresses, so too does the need for tech. The integration of AI is on track to further enhance advancements with precise diagnostic tools and personalized treatment plans. AI is a key support in the success of dental interventions. Are you familiar with the latest AI in healthcare developments? Patient Prism - leveraging AI to enhance the dental patient journey and drive more appointments by 90%. #artificialintelligence #technology #regenerativedentistry #dentistry Image Credit: Robert J. Stanley, DDS, PhD, MS

Bio-implants have become an indispensable part of modern medical procedures, especially in orthopedics and dentistry, where they play a crucial role in restoring functionality to patients. However, the challenge of designing implants with optimal bio-mechanical properties that closely mimic natural bone remains significant. Dense implants often struggle with stress-shielding, while porous structures aim to promote osseointegration but require careful optimization to balance strength and biological compatibility. This course delves into the advanced techniques for manufacturing and optimizing dense and porous bio-implants using Laser Powder Bed Fusion (L-PBF) technology. Learners will gain a comprehensive understanding of how to achieve superior bio-mechanical characteristics through parametric control, post-processing, and biocompatibility assessments. Whether you are a researcher, engineer, or practitioner in the field of biomedical manufacturing, this course will provide you with valuable insights into the latest advancements in implant technology. https://lnkd.in/gcGMjuTt