MGI的动态

At the 10th Anniversary of London Calling, Dr Carika Weldon, MRSB, FIBMS presented groundbreaking research on breast cancer genomics in Caribbean populations, utilizing Geneyx Genomex Ltd. Analysis for advanced NGS tertiary analysis. ?? Key findings from the pilot study: ?? Identification of unique genetic markers specific to Caribbean women Implementation of Oxford Nanopore Technologies for localized, comprehensive testing in Bermuda. ?? 40% of cases positive for BRCA1/BRCA2, with 60% negative, underscoring the necessity for broader genetic screening ?? First-time detection of DNA mismatch repair gene variants in a minority population For detailed insights, access the full study here: https://lnkd.in/ddzDWx63 #WGS #NGS #LondonCalling #BreastCancer #BRCA #GenomicMedicine

??BRCA1 and BRCA2 tumour suppressor genes play a critical role in limiting DNA damage. Mutations in these genes significantly increase the risk of breast cancer, among others. Accurate detection of BRCA variants is essential for guiding cancer treatment strategies and for those carrying inherited mutations to explore preventive measures. Download SeraCare's scientific poster to discover how newly developed reference materials support BRCA1 and BRCA2 genetic testing, offering laboratories and assay developers the tools to optimise NGS-based detection of pathogenic variants. https://ow.ly/Ngfk50TAhOI #ScienceforaSaferWorld #BreastCancerAwarenessMonth #BRCAResearch #GeneticTesting #CancerDetection #AssayDevelopment

National Hereditary Breast and Ovarian Cancer Week reminds us that hereditary cancers can be caused by gene mutations passed down through families. Women with BRCA1 or BRCA2 mutations have a 45-65% risk of developing breast cancer by age 70, along with an increased risk of ovarian cancer. Alarmingly, 75% of BRCA carriers are unaware of their mutation, and 50% of men with BRCA mutations will pass it on to their children. Knowledge is power—let's raise awareness and encourage genetic testing. Get involved by sharing information, promoting genetic testing. Together, we can spread awareness, offer support, and advocate for continued research. Sbarro Health Research Organization Temple University College of Science and Technology #HereditaryCancerAwareness #BRCAWarriors #sbarroinstitute #sbarrohealthresearch #drantoniogiordano

At the 10th Anniversary of @London Calling, Dr. Carika Weldon presented a pilot study on Medicine for Breast Cancer in the Caribbean, using @Geneyx Analysis solution for tertiary NGS analysis. Some highlights from the pilot: - Research is being done to identify unique genetic markers for Caribbean women. - @Oxford Nanopore Technology is being used for local, end-to-end testing in Bermuda. - 40% of cases test positive for BRCA1/BRCA2, while 60% test negative, highlighting the need for expanded testing. - This is the first time DNA mismatch repair gene variants have been identified in a minority population. #wgs #ngs #londoncalling #breastcancer #brca

Ever wonder what's going on in cancer research? Here's an article about what cancer researchers are learning from elephant genes: https://go.iu.edu/7fJi Elephants’ low cancer rates are attributed to their multiple copies of the p53 gene, which enhances DNA repair and regulates cell growth. This genetic advantage allows elephants to effectively prevent the proliferation of cancerous cells. Research into elephant genetics may offer valuable insights for developing new cancer prevention and treatment methods in humans. #BankingOnACure #ResearchCuresCancer #breastcancer #breastcancerresearch #research #WiseWednesday

?? Day 2 of the European Week Against Cancer! Today's theme is Early Detection! ?? Ever wondered if childhood cancers can be detected earlier and what that would mean for the patient and the family? Identifying children with cancer predisposition syndromes (CPS) has significant clinical consequences. Advances in genetics offer potential for preclinical diagnosis, helping at-risk children benefit from genetic testing and counselling. The SIOPE Host Genome Working Group (HGWG) aims to broaden expertise in this field. Check out their work or apply to become a member here: https://lnkd.in/e5pwfq7E European Commission, European Parliament, Council of the European Union ECL Association of European Cancer Leagues #EWAC2024 #EarlyDetection #Genetics

Registration is open for the free webinar 'Accurate variant classification and clinical impact of variability'?as part of our BRCA and HRR gene variant classification assessments (www.genqa.org/BRCA-HRR) for 2024.?This webinar will include:? ·????????CanVIG-UK recommendations for classification of reduced penetrance variants in high-penetrance cancer susceptibility genes?(Dr Alice Garrett, Institute of Cancer research, UK) ·????????Interpretation of Splice variants in HRR genes?(Miranda Durkie, Sheffield Diagnostic Genetics Service, UK) ·????????Review of learning from Run 12?(Prof Kathleen Claes, Ghent University Hospital, Belgium).? Register for this webinar?at https://lnkd.in/edpkM_ZD.? #BRCA #HRR #variantclassification #quality

What’s the role of genetic testing when it comes to cancer? When facing cancer, understanding why it’s happening can make a big difference. Genetic testing helps uncover mutations that might be driving the disease. This information isn’t just science—it’s about better decisions. It can: ?? Guide treatment choices, helping doctors pick the right therapies. ?? Identify inherited risks, which could change care for family members. ?? Predict how aggressive the cancer might be and help us stay one step ahead. That’s why companies like ACT Genomics are focusing on cancer genomics, developing advanced genetic tests for personalized treatment strategies. The more we know about the genetic blueprint of cancer, the better we can fight it.

Unlock the Secrets of Your DNA: Discover the Power of Genetics in Fighting Cancer ?? Did you know that not all cancers are created the same? Genetic changes, from inherited mutations to environmental influences, play a pivotal role in the development of cancer. With groundbreaking advancements in genetic testing, we're empowering individuals with vital knowledge about their risks and the specifics of their cancer. Learn more here: https://ow.ly/J2HR50R7AZa #Cancer #Genetics #DNA

We're thrilled to share our latest research, published in Cell Death and Disease (Nature Portfolio), where we explored the role of the long non-coding (lnc)RNA RAIN in supporting Thyroid Cancer aggressiveness. Through cutting-edge genomics and transcriptomics approaches, we demonstrated how RAIN directly regulates and cooperates with a core of transcription factors, establishing a complex gene network that fuels cancer progression. This unveiled a new functional interplay between RAIN and RUNX2, showing how these factors cooperate on the regulatory regions of a common subset of target genes further supporting tumor metastasis. Check it out! ?? https://lnkd.in/ej5deeni Congratulations to all the authors, Veronica Manicardi, Emanuele Vitale, mila gugnoni, Gloria Manzotti, Teresa Rossi, Elisa Salviato, Benedetta Donati, Federica Torricelli and Ciarrocchi Alessia! This work was supported by Fondazione AIRC per la Ricerca sul Cancro ETS, and thanks to Fondazione Berlucchi for supporting dr Emanuele Vitale during his research abroad. Azienda USL di Reggio Emilia, IRCCS #CancerResearch #ThyroidCancer #lncRNA #genomics #transcriptionfactor #geneexpression #irccs_re #tRES_Lab