MGI的动态

Did we just find a “kill switch” for #cancer? According to a recent reel from BBC, Scientists hypothesised a kill switch to Cancer in space. The cancer tumour triples in size in 10 days in space while it would take a decade on Earth. The reason behind it is the microgravity. Dr. Catriona Jamieson, Hematologist, UC San Diego School of Medicine underscores the significance of this finding by noting that if cancer can proliferate rapidly in space, it opens the door for equally rapid experimentation by scientists. Taking advantage of this phenomenon, the team at UC San Diego tested a new experimental #drug named #Rebecsinib. This drug targets the ADAR1 gene, also known as the cancer cloning gene, aiming to deactivate or genetically suppress it. Preliminary tests conducted during the space mission indicate that #Rebecsinib may indeed act as a promising "kill switch" for cancer. To know more on the experiment, explore here:?https://lnkd.in/drYtRZWY. Dr. Catriona also highlights another intriguing aspect: “Microgravity is like a rocket fuel for aging stem cells”. #Source:?https://lnkd.in/dU3GJAaR Curious about how #microgravity can revolutionise #cancerresearch? Please feel free to reach out to us. Will be back soon with more updates on #Space & #pharma!

?? The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution? ? Tyler et al. significantly extended the Curated Cancer Cell Atlas to 124 datasets for over 40 cancer types, together comprising 2,822 samples, with improved data annotations, visualisations and exploration.?? ? Key points? ? Systematic quantification of context-dependent gene expression and proliferation patterns across cell types and cancer types? ? A comprehensive quantification of cell cycle, revealing high variability in proliferation rates across cell types and cancer types? ? Uncovering biases in cell cycle phases that are associated with driver mutations, most notably TP53? ? Freely available here: https://lnkd.in/eiaRk7k6 ?? More details: https://lnkd.in/eYnC5jQ2 #weizmanninstituteofscience #weizmanninstitute #spatialomics #spatialbiology #singlecellanalysis #singlecell

??????????????????????????: ?????????????????????????? ???????????? ?????????????????? ???? ??????????! The future of cancer therapy is here! ?? Scientists at the Korea Advanced Institute of Science and Technology (KAIST), led by Professor Kwang-Hyun Cho, have developed a groundbreaking treatment that reprograms colon cancer cells to behave like normal cells. ?? Unlike traditional methods that destroy cancer cells but harm healthy tissues and often lead to recurrence, this innovative approach reverses cancer's transformation. Through advanced gene modeling, researchers have identified critical molecular switches that could lead to safer, more effective cancer treatments. ?????? ???? ??????????????: A paradigm shift in cancer therapy, focusing on reprogramming rather than destruction. Potential to minimize harm to healthy tissues and reduce recurrence. Published in Advanced Science, this study offers a beacon of hope for millions battling cancer. This breakthrough underscores the transformative potential of precision medicine. At ???????????? ???????? - ????????????????????, we are proud to celebrate and support innovations that pave the way for a healthier future. ??? #WhatsTrending #CancerResearch #KAIST #PrecisionMedicine #HealthInnovation #ShardaCareHealthcity #FutureOfHealthcare #GameChanger

?? The spatial and cellular portrait of transposable elements in gastric cancer? ? Braulio Valdebenito-Maturana studied single-cell and spatial RNA data publicly available from different cohorts and provide evidence pointing to transposable elements (TEs) as potential biomarkers and regulators of gene expression during gastric cancer.? ? Key findings? ??2,430 TEs as cell population markers? ??111 TEs associated with the origination of cancer cells? ??204 TEs spatially enriched in the tumor regions and the tumor microenvironment? ??~?2,000 genes modulated by TEs, with?~?500 of them already implicated in cancer. ?? More details: https://lnkd.in/epuvKAUa #spatialomics #spatialbiology #singlecellanalysis #singlecell

Unveiling the Hidden Language: Non-Coding Variations and Cancer. While the vast majority of mutations in cancer genomes reside in non-coding regions, these areas remain somewhat of a mystery. Unlike coding mutations that directly alter proteins, non-coding variations can subtly disrupt complex gene regulatory networks.?Pinpointing their exact impact is challenging due to incomplete annotation, intricate network interactions, and potentially smaller effect sizes. However, the potential rewards are significant. By delving deeper into non-coding variations, alongside advancements in tumor whole genome sequencing and epigenetic mapping, we can unlock a new chapter in understanding cancer development. This knowledge can pave the way for the identification of novel driver mutations and the development of more precise cancer therapies. #NonCodingCancer #GeneRegulationRevolution #UnlockingTheGenome #TCGA #NextGenOncology #CancerResearch #Immunotherapy #UniversalCancerVaccine #FundingTheFuture #YouCanHelp?#HopeForACure #Cancer #Hope?#FYP #Explore

?? ???????????? ???? ?????????????????????????? ?? - Gene Editing Magic ?: CRISPR allows precise modifications of T-cells, enhancing immune responses against cancer cells. - Cancer Targeting ??: Custom-engineered T-cells aim at specific tumor cells, increasing treatment efficacy and specificity. - Reduced Side Effects ??: By editing genes responsible for immune regulation, CRISPR minimizes the potential for immune-related complications. - Innovation Wave ??: Current trials are paving the way for groundbreaking personalized cancer therapies. Dive into CRISPR research like never before at https://www.sciqst.com, your go-to source for biomedical literature reviews! #CRISPR #Immunotherapy #GeneEditing #CancerResearch #BiomedicalInnovation

?? Unraveling Tumor Microenvironments with DeMixT ?? Understanding tumor-stroma interactions is crucial for cancer research, and DeMixT is here to help. Developed by MD Anderson Cancer Center, this tool deconvolutes transcriptomic data to reveal critical insights. ?? Why Choose DeMixT? Precision Deconvolution ?? Separate tumor, stroma, and immune components for accurate expression profiling. Gene-Specific Insights ?? Gain expression data at the gene level for each microenvironment component. Flexible Use Cases ?? Apply DeMixT to a variety of cancer types and datasets. Decode the tumor microenvironment with confidence using DeMixT. ?? Enhance your cancer research today! #CancerBiology #Bioinformatics #Microenvironment #Transcriptomics

Hi all! Back with another mind-blowing space and pharma story that will change how you see medical innovation! ? ? Did we just find a “kill switch” for #cancer?? ? According to a recent reel from BBC, Scientists hypothesised a kill switch to Cancer in space.? ? The cancer tumour triples in size in 10 days in space while it would take a decade on Earth. The reason behind it is the microgravity.? ? Dr. Catriona Jamieson, Hematologist, UC San Diego School of Medicine underscores the significance of this finding by noting that if cancer can proliferate rapidly in space, it opens the door for equally rapid experimentation by scientists.? ? Taking advantage of this phenomenon, the team at UC San Diego tested a new experimental #drug named #Rebecsinib. This drug targets the ADAR1 gene, also known as the cancer cloning gene, aiming to deactivate or genetically suppress it. Preliminary tests conducted during the space mission indicate that #Rebecsinib may indeed act as a promising "kill switch" for cancer.? ? To know more on the experiment, explore here: https://lnkd.in/drYtRZWY. ? ? Dr. Catriona also highlights another intriguing aspect: “Microgravity is like a rocket fuel for aging stem cells”.? ? Source: https://lnkd.in/dU3GJAaR? ? Curious to learn more? Drop your questions below or schedule a call: https://lnkd.in/ebUk8Bzn?? ? Stay tuned for another exciting update next week.?

Researchers, led by Professor Kwang-Hyun Cho at the Korea Advanced Institute of Science and Technology (KAIST), have developed a new technology that transforms cancer cells into normal-like cells, potentially avoiding side effects and the risk of recurrence. The team used a computer model to understand the gene network that controls normal cell development. They identified molecular switches that can turn colon cancer cells back into normal-like cells. Unlike conventional therapies that destroy cancer cells, this approach targets the root cause of cancer by reversing the cell's abnormal development. The method was tested through experiments and animal trials, showing promising results. Researchers believe this technology could be applied to other types of cancer as well, offering a new treatment option with fewer side effects and a lower risk of recurrence. #Korea #CancerResearch #Cancer #KAIST #CancerTherapy #CancerCure #CancerRecovery #Science #Medical #businessdor

?? Uncovering New Insights into Pancreatic Cancer Progression ?? A research team at the The Johns Hopkins University School of Medicine investigated how a cellular transition state—acinar-to-ductal metaplasia (ADM)—drives pancreatic cancer by retaining "epigenetic memory" in cells, even in the absence of cancer-promoting mutations. They discovered persistent DNA methylation changes in key signaling pathways, linking this memory to increased cell plasticity, a major driver of cancer progression. Using Vizgen's #MERSCOPE spatial transcriptomics platform powered by #MERFISH technology, the team applied a 500-gene custom panel to reveal co-expression of cell type signatures in cells undergoing ADM. ??https://hubs.ly/Q02WjP6w0 #SpatialGenomics #SingleCell #Multiomics #SpatialBiology