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Maanas Samant, MD

CMIO @ Ionixx Technologies | Physician Consultant, Health AI

I was linked this article, and as always with sensational headlines, I dug deeper, starting with the originally published paper. It's pretty cool. The researchers developed an AI model that could potentially help identify new compounds for chronic pain relief by predicting interactions between molecules and pain-related receptors. This could be a significant step forward in finding non-opioid treatments for pain. However, from a clinical standpoint, it's important to note that this is highly, HIGHLY theoretical at this stage. This is like someone publishing a treasure map based on their research of a historical shipwreck, then headlines declaring "Sunken Treasure Found in Atlantic!" We have an intriguing start, but there's a long journey ahead before any treasure is actually discovered. The model doesn't account for a lot of stuff, including ADMET properties - Absorption, Distribution, Metabolism, Excretion, and Toxicity - which are crucial for determining a drug's suitability for human use. Just because a compound shows potential in a computer model doesn't mean it will be safe or effective in living organisms (i.e. Bleach kills Covid meme... yes true but it also kills humans if ingested). Obviously hasn't progressed to in vitro (test tube) or in vivo (animal or human) testing yet either. That said, this research represents a promising step forward. By starting with a large pool of potential compounds, AI can help narrow down candidates for further testing. This could streamline the drug discovery process: starting with hundreds of compounds, refining to dozens through laboratory research, and eventually bringing a couple of effective and safe options to market. It's exciting to think that AI could help us identify new compounds for chronic pain relief. However, we're likely many years away from seeing these AI-discovered drugs become available treatments. Newer, existing approved medications are already prohibitively expensive and inaccessible to patients - for example, drugs like Zolgensma and Luxturna cost about a million dollars+ per treatment. So, while AI holds great promise for the future of drug discovery, especially for conditions like chronic pain, we need to temper our excitement with a dose of reality. There's a long road from computational models to real-world treatments, but every journey starts with a first step~ #AIDrugDiscovery #PainManagement #HealthcareInnovation #ArtificialIntelligence

Researchers use AI to find non-opioid pain relief options

Researchers use AI to find non-opioid pain relief options

medicalxpress.com

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