Researchers from Fraunhofer IZI demonstrated that linker-specific mAbs can detect different CAR-NK cells in vitro with high specificity and sensitivity, providing an effective and almost universal alternative for scFv-based CAR detection. Linker-specific antibodies can also be used for functional testing and enrichment of CAR-NK cells, thereby providing a useful research tool to fast-track the development of novel CAR-based therapies. CAR-Natural Killer (NK) cells can be applied as allogeneic cell therapy, providing an economical, safe and efficient alternative to autologous CAR-T cells. As most existing CARs contain a single-chain fragment variable (scFv), linker-specific monoclonal antibodies (mAbs) can detect a broad range of CARs. Read the paper here: https://lnkd.in/gwk_FPPP #Biointron #Antibodies #Monoclonal #scFv #DrugDevelopment #CARNK #CART
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Mitochondrial Transfer: A New Era for T Cell Therapies ?? ??! In a recent study published in Signal Transduction and Targeted Therapy, Lars Fabian Prinz and colleagues (University of Cologne) demonstrate a novel mitochondrial transfer platform. Bone marrow stromal cells (BMSCs) transfer functional mitochondria to CD8+ T cells via tunneling nanotubes (TNTs), enhancing their metabolic fitness and resistance to exhaustion. The results highlight significant improvements in T cell anti-tumor activity and survival in preclinical models. While challenges like transfer efficiency remain, this approach could redefine mitochondrial-based strategies for adoptive T cell therapies. ?? : https://lnkd.in/diHm92KY #WorldMitochondriaSociety #WMS #TargetingMitochondria #Mitochondria #CellTherapy #TCellInnovation #Immunotherapy
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Missed episode 2 of our webinar series "Oligonucleotide Therapeutics: Discovery to Development"? Watch it on demand! In this webinar, titled "New Mechanisms and Targets for microRNAs Therapeutics", our guest speaker Dr. David Corey, Rusty Kelley Professor of Biomedical Research, UT Southwestern University, explores the therapeutic potential of miRNA- targeting treatments, outlining cutting-edge research that is identifying new miRNA targets. He also discusses the latest methodologies in miRNA research, including next-generation sequencing and miRNA inhibition. Watch on-demand now! https://hubs.ly/Q02Rtbp20 #microRNA #Therapeutics #Oligonucleotides
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Missed episode 2 of our webinar series "Oligonucleotide Therapeutics: Discovery to Development"? Watch it on demand! In this webinar, titled "New Mechanisms and Targets for microRNAs Therapeutics", our guest speaker Dr. David Corey, Rusty Kelley Professor of Biomedical Research, UT Southwestern University, explores the therapeutic potential of miRNA- targeting treatments, outlining cutting-edge research that is identifying new miRNA targets. He also discusses the latest methodologies in miRNA research, including next-generation sequencing and miRNA inhibition. Watch on-demand now! https://hubs.ly/Q02Rt98x0 #microRNA #Therapeutics #Oligonucleotides
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Missed episode 2 of our webinar series "Oligonucleotide Therapeutics: Discovery to Development"? Watch it on demand! In this webinar, titled "New Mechanisms and Targets for microRNAs Therapeutics", our guest speaker Dr. David Corey, Rusty Kelley Professor of Biomedical Research, UT Southwestern University, explores the therapeutic potential of miRNA- targeting treatments, outlining cutting-edge research that is identifying new miRNA targets. He also discusses the latest methodologies in miRNA research, including next-generation sequencing and miRNA inhibition. Watch on-demand now! https://hubs.ly/Q02RtbPk0 #microRNA #Therapeutics #Oligonucleotides
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Missed episode 2 of our webinar series "Oligonucleotide Therapeutics: Discovery to Development"? Watch it on demand! In this webinar, titled "New Mechanisms and Targets for microRNAs Therapeutics", our guest speaker Dr. David Corey, Rusty Kelley Professor of Biomedical Research, UT Southwestern University, explores the therapeutic potential of miRNA- targeting treatments, outlining cutting-edge research that is identifying new miRNA targets. He also discusses the latest methodologies in miRNA research, including next-generation sequencing and miRNA inhibition. Watch on-demand now! https://hubs.ly/Q02Rt7J80 #microRNA #Therapeutics #Oligonucleotides
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The journey to perfecting Chimeric Antigen Receptor (CAR) constructs for CAR-T cell therapy is filled with challenges, especially in achieving precise specificity for target antigens. These hurdles can lead to tumor resistance, unwanted effects, and toxicities. Enter advanced optical biosensing technology! Biolayer Interferometry (BLI) is advancing the field by offering real-time, label-free analysis of biomolecular interactions. This cutting-edge technology provides crucial insights into binding kinetics and affinities, all without altering the biomolecules. Discover how the Octet? BLI system is paving the way for innovative CAR construct creation and testing in both research and clinical settings in our latest article. Article highlights: ?? Challenges in CAR development ?? Strategies for fine-tuning specificity to minimize side effects ?? Tips for addressing high and low antigen densities ?? Approaches for targeting solid tumors with low antigen density Learn more: https://ow.ly/bTF350U92vL #OctetBLI #CellTherapy #CancerResearch #Sartorius #BiolayerInterferometry #OncologyResearch #Biotechnology
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BLOG ALERT: Cell-based assays sit at the core of cell therapy research and development and are crucial for ensuring the safety and efficacy of new treatments. However, the success of these assays heavily relies on the viability of cell samples, which can be compromised by conventional separation techniques. Our latest blog highlights how Levitation Technology? is revolutionizing sample preparation, ensuring higher cell viability and boosting the accuracy and reliability of assays. Discover how levitation innovation is transforming cell therapy R&D for safer, more effective treatments. Dive into the full story here: https://bit.ly/3UFbETL #CellTherapyResearch #LevitationTechnology #SamplePreparation
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The latest blog highlights show you how Levitation Technology? is revolutionizing sample preparation, ensuring higher cell viability and boosting the accuracy and reliability of assays. Read the blog from LevitasBio to learn more! #Blog #Revolution #Cells #Explore #CellTherapy #Research
BLOG ALERT: Cell-based assays sit at the core of cell therapy research and development and are crucial for ensuring the safety and efficacy of new treatments. However, the success of these assays heavily relies on the viability of cell samples, which can be compromised by conventional separation techniques. Our latest blog highlights how Levitation Technology? is revolutionizing sample preparation, ensuring higher cell viability and boosting the accuracy and reliability of assays. Discover how levitation innovation is transforming cell therapy R&D for safer, more effective treatments. Dive into the full story here: https://bit.ly/3UFbETL #CellTherapyResearch #LevitationTechnology #SamplePreparation
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Hear from leading scientists on how the Beacon? platform is transforming research. Watch our on-demand roundtable discussion: 'Understanding the Life of Single Cells' ?Hear firsthand from industry experts how function-first assays can drive antibody discovery for difficult targets ?Understand why the Beacon instrument is amongst the most widely adopted technologies for cell line development and has become the Gold Standard ?Learn from both academic and industry experts on the technical advancements in single cell functional analysis Discover how the Beacon platform can elevate your CAR/TCR discovery, T cell profiling, cell therapy, antibody discovery, and cell line development. Watch on-demand: https://hubs.ly/Q032Qqlg0 #SingleCellResearch #BeaconTechnology #ScientificInnovation #Webinar
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Bioreversible lipid nanoparticle anionic cloaking: in their latest study, Matt DeLisa, Christopher Alabi and collaborators at Cornell University investigated a reversible bioconjugation method to alter the surface charge of protein cargos in LNPs, employing an anionic "cloak." This approach aimed to enhance electrostatic complexation of LNP formulations and improve drug delivery https://lnkd.in/efkK7XJk They applied this strategy to effectively deliver RNase A for cancer cell eradication and a full-length antibody to suppress oncogenic β-catenin signaling. Additionally, they demonstrate that LNPs encapsulating cloaked fluorescent proteins distribute to major organs in mice after systemic administration. An article also authored by Azmain Alamgir and Souvik Ghosal #LNP #drugdelivery #nanomedicine #formulation #Vesiculab
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