CEPI (Coalition for Epidemic Preparedness Innovations)的动态

In the recent report prepared by the US National Academies, the dire situation the US government could face in the event of a smallpox outbreak is highlighted. The report concludes that investments in the development of improved smallpox vaccines, enhanced diagnostics, and more effective therapeutics are crucial. Smallpox virus samples still exist in two laboratories: the CDC in Atlanta, US, and the State Research Center of Virology and Biotechnology in Koltsovo, Russia. The report also raises concerns about the potential to re-engineer the smallpox virus using publicly available genetic sequences. Corpses preserved in permafrost could harbor infectious viruses, which might be exposed due to global warming. #smallpox #outbreak #health #globalhealth #publichealth #medicine #biotechnology #pharmaceuticals #FDA #WHO #CDC #vaccines https://lnkd.in/gKTxucgF

To facilitate vaccine access in the region, MpoxReC calls for urgent support for high-quality roll-out at each step of the vaccine distribution and monitoring chain. This roll-out includes strengthening policy discussion through regional and national immunisation technical advisory groups and ensuring capacity for vaccine assessment by national regulatory authorities with support from the African Vaccine Regulatory Forum and African Medicines Regulatory Harmonization.

A news article published in Science discusses evidence suggesting that a poliovirus batch found in a laboratory could be behind the origin of a virus that infected at least one patient in China. The isolate from this Chinese patient was studied at the Wuhan Institute of Virology and is highly similar to a poliovirus batch that Albert Sabin sent to the Pasteur Institute in Paris back in 1960. Although other alternatives are possible, one hypothesis suggests that the Chinese virus may have originated from one of the virus batches sent by Sabin to Pasteur, which may have somehow leaked into the wild later. Although there are no scientific arguments supporting one hypothesis over others, some researchers are convinced of the laboratory leak scenario. It is noteworthy that examples of poliovirus infections mediated by contamination or escape of vaccine-derived viruses have occurred several times. Furthermore, poliovirus cases derived from vaccine-derived viruses are known to occur rarely, with frequencies estimated at one infection for every 2 to 4 million doses of the oral poliovirus vaccine (OPV). Administration of OPV (which is not given in the U.S.) remains an important roadblock for the global eradication of poliovirus. #publichealth #polio #poliovirus #health #medicine #biotechnology #pharmaceuticals #pandemic #infectiousdiseases #WHO #CDC ?#vaccines #Pasteur https://lnkd.in/gsjXfGw9

~Responding to Global Health Challenges with Innovation~ In light of the recent declaration by the Africa CDC and World Health Organization regarding #Mpox as a public health emergency of international concern, Helix Biogen Institute is proud to share our latest publication: "Exploring Computational Approaches to Design mRNA Vaccines Against Vaccinia and Mpox Viruses." https://lnkd.in/dQUMs27U This has led to development of a MRNA Vaccine Candidate which took us two years to developed and get part published by Wiley As the world faces urgent health challenges, our research as scientists from Africa focus on leveraging cutting-edge computational techniques to accelerate the development of mRNA candidate vaccines , specifically targeting these high-priority pathogens. This work underscores our commitment to contributing to global health security and addressing emerging infectious diseases. Together, we can unlock the future of healthcare through science and innovation. Thanks to Dr. Oladipo Elijah Kolawole (Ph.D), Dr Helen Onyeaka, FIFST, FHEA, Olatunji Matthew KOLAWOLE, Boluwatife Ayobami Irewolede, Olumuyiwa Ariyo, Bamidele Iwalokun and others for contributing to the success of this work from Africa. #GlobalHealth #Vaccines #Mpox #mRNA #Biotechnology #PublicHealth #AfricaCDC #WHO #HelixBiogenInstitute #InternationalHealthRegulations Akyala Ishaku Ph.D Ajani Olumide Faith (BMLS,M.Sc,MBA,FWAPCMLS,FACSC,PhD) CEPI (Coalition for Epidemic Preparedness Innovations) UNICEF United Nations Vaccine and Infectious Disease Organization (VIDO) Champions for Vaccine Education, Equity and Progress Tedros Adhanom Ghebreyesus

https://lnkd.in/gxANQgjq ?? ?? Article title: An Overview: Laboratory Safety and work Practices in Infectious Disease Research ? Author(s): Shivaji K Jadhav* ? Journal: Journal of HIV for Clinical and Scientific Research ? Journal ISSN: 2455-3786 Abstract: Occupational exposure and risk of acquiring the infections is a very serious issue and it plays an important role concerned to personnel safety in the laboratory. It is very much essential to emphasis on safety aspects for each personnel working in infectious laboratories. This review article provides an insight on bio safety practices to be followed for safe and effective functioning of the laboratory to prevent the occupational exposure. ? Bio safety practice is designed as per international standards to help a safe and healthy environment that adequately supports good work practices. This review is mainly focused on bio safety practices which will provide sufficient information and SOPs should be used in conjunction with other resources to work safely with biohazard or any infectious agents in the laboratory. It will also commit to provide knowledge for safe laboratory environment for laboratory staff, trainees and also healthcare workers. In laboratories, there are many tasks that involve numerous risks factors to the laboratory staff [1]. Thus, any incident associated with a given microbiological hazard is probably most likely to happen in infectious laboratory. However, incidents are not only associated to a single factor [2]. Further these practices shall be practiced routinely to achieve the highest ethical and professional standards possible to protect the health of staff, the public, and the working environment, There are biological risks in health sector in biotechnology by bacteria, viruses, rickettsiae, fungi, and parasites [3,4]. ? #Bio-SafetyCabinets #InfectiousDiseaseResearch #GoodLaboratoryPractices #SafetyLaboratoryPractices #EpidemiologyOfHIVSpreadAndResistance #DiagnosticsEarlyDetectionAndMonitoring #IdentificationOfViralTargets #DevelopmentOfAgentsWithNovelMechanismsOfAction #OptimalClinicalUseOfExistingAntivirals #VaccineDevelopment #Peertechz #ManagementAndTreatmentOfAssociatedDisordersInAIDSPatients #PatientAdherenceQualityOfLifeSatisfaction #ConsumerAndPatientEducationAndHealthLiteracyPrograms #HealthEconomicsAndPublicHealthPolicy #PathophysiologyOfNeuropsychiatricAndBehavioralComplications #NeuroImmunologyAndBiomarkers #ViralGeneticVariabilityAndLinkToNeuroOutcomes #NeuroImagingInHIVInfection #PeertechzPublications #ImpactOfHIVTreatmentsOnNeuroBehavioralFunction #ConcomitantInfectionsSuchAsHepatitisCOnCNSFunction #SubstanceAbuse #SpecialPopulationsAndNeuroAIDS #ManagementStrategiesAndPharmacologicalInterventions #DiagnosisOfHIVAIDS #EpidemiologyOfHIVAIDS #OpportunisticInfectionsInHIVAIDS #PathogenicityOfHIVAIDS #PoliticalEconomyOfHIVInfectionAIDS #PreventionOfHIVAIDS #TreatmentOfHIVAIDS #VirologyAndImmunologyOfHIVAIDS

NEW REPORT URGES ENHANCED PREPAREDNESS AS SMALLPOX THREAT LOOMS Explore the imperative for the United States to strengthen defenses against the potential resurgence of smallpox, highlighted in a recent report commissioned by the U.S. government. Emphasizing strategic investments in vaccines, diagnostics, and therapeutics, the report underscores the need for enhanced preparedness and international cooperation. https://lnkd.in/dpsq2ZHD

?? New Online special issue: Novel Vaccines development for Emerging, Acute, and Re-emerging Infectious Diseases is open for submissions now!! Welcome join us and discuss this topic! ?? Edited by Dr. Wenping Gong and Dr. Ashok Aspatwar, Ph.D. ?? This special issue aims to spotlight innovative strategies and scientific advancements in vaccine research against these critical health threats. It seeks contributions that push the frontier of vaccine science, from identifying new pathogen targets using cutting-edge techniques to designing vaccines that are effective across diverse populations. In addition to discussing traditional methodology, this issue will emphasize how modern computational approaches and cross-disciplinary technologies can radically advance our capability to design effective vaccines more rapidly and precisely. #vaccine #Infectiousdiseases #Adjuvants #Bioinformatics ?? Submission deadline: December 31, 2024 ?? APC: No article processing charge ?? Link to get more details: https://lnkd.in/gzcVXusm Tampere University #highereducation #collaboration #publications #research #cooperation

?? New Online special issue: Novel Vaccines development for Emerging, Acute, and Re-emerging Infectious Diseases is open for submissions now!! Welcome join us and discuss this topic! ?? Edited by Dr. Wenping Gong and Dr. Dr. Ashok Aspatwar, Ph.D. ?? This special issue aims to spotlight innovative strategies and scientific advancements in vaccine research against these critical health threats. It seeks contributions that push the frontier of vaccine science, from identifying new pathogen targets using cutting-edge techniques to designing vaccines that are effective across diverse populations. In addition to discussing traditional methodology, this issue will emphasize how modern computational approaches and cross-disciplinary technologies can radically advance our capability to design effective vaccines more rapidly and precisely. #vaccine #Infectiousdiseases #Adjuvants #Bioinformatics ?? Submission deadline: December 31, 2024 ?? APC: No article processing charge ?? Link to get more details: https://lnkd.in/gzcVXusm

?? Exciting Research Update! ?????? Recent research delves into the “Efficacy of Current Vaccines Against Recently Isolated Foot and Mouth Disease Virus Type A (South America, Venezuela) in Egypt 2022.” ???? ?? The study explores the effectiveness of existing vaccines in combating a specific strain of the foot and mouth disease virus originating from South America, specifically Venezuela, and its impact in Egypt. ?? Understanding the adaptability of vaccines across regions is crucial for global health. This research sheds light on potential challenges and solutions in preventing the spread of this virus. ???? Stay tuned for deeper insights into the study’s findings and implications for vaccine strategies against emerging strains. #Research #FootAndMouthDisease #VaccineEfficacy #GlobalHealth ????