A recent paper demonstrates that in regions with high malaria prevalence, repeated malaria infections lead to the broadening of antibody diversity and continued presence of atypical memory B cell populations. ?? Key terms: ??Antibody breadth: The number of antigens to which an individual has higher antibody titres. ??Antibody avidity: A measure of the cumulative binding strength between the antibody and antigen is derived from the affinities of numerous individual non-covalent interactions. While typical immunity to malaria develops slowly after repeated episodes of infection, chronic exposure has been linked to perturbation in B-cell homeostasis with the accumulation of atypical memory B cells. Read the full paper at Nature Portfolio: https://lnkd.in/ejBcDimC #Biointron #Antibodies #Malaria #MemoryBCells #AntibodyProduction
