Whitehead Institute

Meet Sheri Grill, a postdoc in the Lehmann lab studying how germ cells regulate their genes in order to remain totipotent: https://lnkd.in/gEQzSFMg #WhiteheadPostdocProfiles

Whitehead Fellow Allison Hamilos uses clues from human disease to understand how our brains enable spontaneous behavior. Watch the full webinar: https://lnkd.in/eu_u3ciq

CHARM, a gene-silencing tool developed in the Weissman lab, shows promise as a therapy against fatal prion diseases. https://lnkd.in/gmuNXmYa

“For my entire career, I’ve wanted to see what happens in cells when the function of an essential gene is eliminated. Now, we can do that, not just for one gene but for every single gene that matters for a human cell dividing in a dish," Whitehead Institute Member Iain Cheeseman says. https://lnkd.in/eDeAzY5Z

Bats rarely get sick from deadly viruses like Ebola and Nipah despite carrying them. The Jaenisch lab has found that while the SARS-CoV-2 virus can enter bat cells, the innate immune system prevents it from replicating and hijacking the cell's machinery. https://lnkd.in/eqZpuqZq

We are excited to share a study from our lab describing a novel strategy to rapidly produce, test, and validate bispecific antibodies for lymphoma! This work was led by Juliano Ribeiro and Carlota Pagès Geli in collaboration with the lab of Marta Crespo at Vall d'Hebron Institute of Oncology (VHIO). Here, we describe a novel strategy to identify new and unappreciated antibody targets on the surface of lymphoma cells. We leveraged this information to rapidly assemble and test 156 bispecific antibodies that target B-cell lymphoma. We identified a multitude of new antibodies that stimulate robust immune-mediated destruction of B-cell lymphoma, including WTa2d1xCD38, a SIRPa decoy crossed with a CD38-targeting domain. These bispecifics could eliminate lymphoma cells in vitro and stimulate anti-tumor responses in mouse models of cancer, including an aggressive model of primary CNS lymphoma. As a next step, we hope to translate these discoveries to the clinic to benefit patients. In the future, we are excited to apply this same approach to other types of cancer to rapidly generate new, transformative therapies for patients. We are thankful to funding sources to support this work, including the Valhalla Foundation and the American Association for Cancer Research. To learn more about our lab's work at Whitehead Institute, please visit us here: www.weiskopf-lab.org https://lnkd.in/exGV33Su

Meet Jaspreet Sandhu, a postdoc in the Weissman lab studying how the genetics of individual cells determine their behaviors within the liver. https://lnkd.in/ekicmPP9 #WhiteheadPostdocProfiles

Whitehead Institute, a leading biomedical research institute in Cambridge, Massachusetts, is hiring a Genome Technology Core (GTC) Director: https://lnkd.in/eAcUTPtf

In this edition: Whitehead Institute Member Sebastian Lourido's work in Toxoplasma.

Tune in this afternoon. Whitehead Fellow Allison Hamilos uses clues from neurodegenerative diseases to understand how our brains enable spontaneous behavior: https://lnkd.in/ezSGA5kQ