Vizgen

Mapping Neural Crest Development in Zebrafish with Spatial Transcriptomics ??? A new pre-print study from researchers at University of Oxford, Wuhan University, Helmholtz Center Munich and the Stowers Institute for Medical Research, highlights an important discovery in neural crest migration. Using Vizgen’s MERSCOPE? Platform, researchers identified 10 gene programs driving 23 neural crest states. They also uncovered a previously unknown endothelial-like program that regulates neural crest migration, separate from epithelial-to-mesenchymal transition (EMT). These findings refine our understanding of neural crest development and provide new pathways for studying developmental disorders and regenerative medicine. MERSCOPE enabled the researchers to: ??Spatially validate neural crest states with a custom 300-gene panel across developmental stages. ??Map gene expression at high resolution, enhancing the understanding of cell interactions. ??Validate computational predictions, bridging in silico models with real-world biology. This pre-print demonstrates MERSCOPE’s versatility across species, reinforcing its power in decoding complex gene networks in dynamic developmental processes. Read the full pre-print: https://hubs.ly/Q03cJRlf0 #SpatialBiology #Transcriptomics #MERSCOPE #SingleCell

??We’re proud to be a commercial discount partner with the Human Cell Atlas (HCA), a global consortium on a mission to map every human cell type with high-resolution and spatial context. Vizgen provides HCA members exclusive discounts to accelerate their research and uncover detailed insights into cellular organization, tissue architecture, and molecular interactions. Leveraging the accuracy and power of our MERFISH chemistry, the MERSCOPE Ultra? platform provides a tissue-wide view of transcripts and superior cell segmentation across an unprecedented 3cm2 of sample tissue on a single slide. Claim your HCA member discount here: https://hubs.ly/Q03cC-Sq0 #SpatialBiology #HumanCellAtlas #MERFISH

Partnerships drive discovery. ?? We’re excited to partner with Scale Biosciences to help researchers unlock deeper biological insights through the complementary technologies from Vizgen’s MERSCOPE? Platform and Scale Bio’s single-cell RNA and DNA methylation sequencing. By working together, we look forward to helping researchers advance their complex, high resolution biology through: ??Multi-omic integration: Combining single-cell RNA sequencing or DNA methylation with spatial transcriptomics data provides a deeper, more comprehensive understanding of complex biology. ??The overlay of spatial transcriptomics and epigenetic data: Aligning gene expression with epigenetic states reveals how molecular patterns are organized within tissues, helping to distinguish cell types and functional states. ??Enhanced data interpretation: Integrating these data types improves spatial mapping accuracy, enabling more detailed tissue profiling. Learn more about the partnership and explore the science: https://hubs.ly/Q03cshCs0 #SpatialBiology #MERSCOPE

?We’re thrilled to welcome our long-time collaborators at the Sanderson Center for Optical Experimentation (SCOPE) to our global Certified Service Provider network! Based at UMass Chan Medical School, SCOPE combines expertise in advanced quantitative imaging with Vizgen’s MERFISH technology, offering high-resolution spatial transcriptomics for researchers studying gene expression at single-cell resolution. As an early adopter of MERFISH and one of the first installation sites for MERSCOPE Ultra?, SCOPE now provides full-service spatial genomics solutions, from sample preparation through imaging and data processing, empowering researchers with a tissue-wide view of up to 1,000 genes at single-cell resolution. SCOPE has undergone rigorous training in Vizgen’s wet lab and data analysis workflows, ensuring best-in-class data quality and service. ??Learn more about SCOPE and our growing Certified Service Provider network: https://hubs.ly/Q03bRZlJ0 #SpatialBiology #MERSCOPE #MERFISH

?We’re proud to be a commercial discount partner with the Human Cell Atlas (HCA), a global consortium mapping every cell type in the human body to increase understanding of human health and drive innovation in personalized medicine. Vizgen provides HCA members exclusive discounts to accelerate their research and uncover detailed insights into cellular organization, tissue architecture, and molecular interactions. Leveraging the accuracy and power of our MERFISH chemistry, the MERSCOPE Ultra? platform provides a tissue-wide view of transcripts and superior cell segmentation across an unprecedented 3cm2 of sample tissue on a single slide. Learn more and claim your HCA member discount today: https://lnkd.in/gcsPZft4 #SpatialBiology #HumanCellAtlas #MERFISH

Collaboration is critical for driving breakthrough discoveries. ? That’s why we’re launching our new Vizgen Partners Program—a growing network of industry leaders working together to empower researchers with unparalleled tools and technologies. By uniting complementary expertise and cutting-edge technologies, the Vizgen Partners Program enables researchers to gain deeper spatial insights into cellular heterogeneity, tissue architecture, and complex biological processes. From oncology to neuroscience and beyond, we are excited to see how these partnerships shape the future of spatial biology. Learn more about the Vizgen Partner Program: https://hubs.ly/Q03bdVKV0 #SpatialBiology

?? Skin is no barrier to spatial insights with MERFISH 2.0 Spatial analysis of skin tissue has always been challenging due to its dense structure and transcript diversity. MERFISH 2.0 overcomes these hurdles with enhanced sensitivity and specificity, unlocking hidden biological insights with unmatched precision. ?? In a recent FFPE mouse skin study with Vizgen Lab Services, MERFISH 2.0 demonstrated significant improvements in transcript detection efficiency, revealing new layers of tissue architecture and gene expression. This breakthrough paves the way for deeper exploration of cellular dynamics in complex tissues like skin. More transcripts. More cells. More insights with MERFISH 2.0. ?? Excited to see the next era of MERFISH? Preview MERFISH 2.0 early data and pre-order now: https://hubs.ly/Q039_kXm0 #SpatialBiology #MERFISH #FFPE

Dive Deeper into the Chemistry of MERFISH 2.0 ?? MERFISH 2.0 isn't just an upgrade—it's advancing spatial biology to even greater depths with optimized chemistry: ??Improved RNA anchoring preserves transcript integrity for reliable results. ??Optimized probe binding increases probe binding efficiency for accurate targeting. ??Augmented read-out probe design delivers a higher signal to uncover hidden insights. ??Sign up now to access exclusive datasets and early customer feedback: https://hubs.ly/Q039lvxV0 #SpatialGenomics #MERFISH #Vizgen

Dive Deeper into the Chemistry of MERFISH 2.0 ?? MERFISH 2.0 isn't just an upgrade—it's advancing spatial biology to even greater depths with optimized chemistry: ??Improved RNA anchoring preserves transcript integrity for reliable results. ??Optimized probe binding increases probe binding efficiency for accurate targeting. ??Augmented read-out probe design delivers a higher signal to uncover hidden insights. ??Sign up now to access exclusive datasets and early customer feedback: https://hubs.ly/Q039lvxV0 #SpatialGenomics #MERFISH #Vizgen

We’re excited to announce our partnership with Boudicca DX to advance Vizgen’s clinical and regulatory strategies for our spatial biology and multi-omics tissue-based assays.? By integrating Boudicca DX's expertise, we look forward to expanding our breakthrough MERFISH technology and MERSCOPE? Platform beyond clinical research to regulatory-compliant precision medicine tests to better inform therapeutic decisions and improve patient outcomes. Learn more: https://hubs.ly/Q039x7k60 #SpatialBiology