UGenome AI

Emerging Trends 211 | Pharmacogenomics in Pregnancy: Personalized Medicine for Expecting Mothers Miley Nguyen, PharmD & Niharika Koppulu What if the medications prescribed during pregnancy could be tailored to the genetic profile of the mother and her unborn child? Pharmacogenomics (PGx) has immense potential to serve as the foundation for personalized healthcare throughout a woman's life, particularly in the context of prenatal care. By addressing gender-specific health needs, leveraging frequent medical consultations, and accounting for long-term health outcomes, PGx can potentially transform maternal care. PGx plays an important role in addressing gender-specific health challenges. Women’s healthcare often involves managing conditions unique to reproductive biology, such as hormonal imbalances and pregnancy-related complications. During pregnancy specifically, the challenges heighten as physiological changes alter drug absorption, metabolism, and excretion (Betcher et al., 2022). For instance, the activity of liver enzymes such as CYP2D6 and CYP3A4 are essential for metabolizing drugs. In women who have the existing genetic variations in these enzymes, these changes can further complicate their treatment. PGx offers a solution by enabling clinicians to anticipate genetic variants and tailor therapy accordingly. Pregnancy requires frequent doctor visits, ranging from routine prenatal check-ups to specialized consultations for managing chronic or high-risk conditions. These regular meetings offer clinicians the opportunity to implement PGx-driven preventative care into standard prenatal care protocols. Research indicates that approximately 80% of pregnant women are prescribed at least one medication, many of which have PGx implications (Anwar, 2020). For example, ondansetron, used for morning sickness, is metabolized by CYP2D6. Rapid metabolizers break it down too quickly, reducing effectiveness, while poor metabolizers process it slowly, increasing drug levels and side effects (Slattery et al., 2022). Pregnancy often marks the beginning of a woman’s interaction with the healthcare system, as the medical decisions made during this time can have lasting implications. PGx can mitigate the risks and offer a promising pathway to revolutionize prenatal care, ensuring that both mother and baby receive optimal treatment tailored to their genetic makeup. Anwar, Y. (2020). Lack of females in drug dose trials leads to overmedicated women | Research UC Berkeley. Betcher, HK, & George, AL. (2020). Pharmacogenomics in pregnancy. Seminars in Perinatology. Slattery J, et al. Ondansetron use in nausea and vomiting during pregnancy: A descriptive analysis of prescription patterns and patient characteristics in UK general practice. Br J Clin Pharmacol. 2022. #ugenome #ugenomeai #genetics #pharmacogenetics #genomicmedicine #sequencing #datascience #lifesciences #bioinformatics #biostatistics #pharma #WomensHistoryMonth

UGenome is a proud Registered Scientist.com Supplier! https://lnkd.in/gY4NHXWG You can get UGenome's bioinformatics services including Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Phylogenetic?Analyses, and Herpes Virus Antibody?Analyses from Scientist.com. #ugenome, #scientistcom, #bioinformatics

"Decoded by UGenome" is UGenome AI's monthly newsletter to give our followers, fans, partners, and future collaborators and investors a quick summary of UGenome's program to "make genomic medicine personal and accessible for everyone." Please take 5 seconds to repost to your networks. Jayden Lee, EMBA, PharmD, BCACP Peter Bannister Komal Sharma Ben Stansfield Miley Nguyen, PharmD, RPh Raymond Lorenz Ayse ULGEN, PhD, MGM Alan Thomas Kohler, PhD Emma Bardin Laura Hong, Ph.D. Trevor Byrum, EMBA Julia Seraphine Husna Rahim, PharmD, RPh Jennifer Tovar Jeffrey M Carrier Anishek Kamal Jeff Jenkins Robert Brown, Ph.D. Randall Stafford Phillip Stafford Chris Diehnelt Chris Moore Christopher Lent Chris Yoo Christopher Aleong Chris Paxton Bob DeLean Jack Florio Christiaan Engstrom Kevin Parker Arizona BioIndustry Association (AZBio) Flinn Foundation Peter Nestler TheraCea Pharma Robust Diagnostics, LLC Jura Health Ezra Smith San Diego Regional Economic Development Corporation Tech Launch Arizona

Saint Patrick's Day, or the Feast of Saint Patrick (Irish: Lá Fhéile Pádraig, lit.?'the Day of the Festival of Patrick'), is a religious and cultural holiday held on 17 March, the traditional death date of Saint Patrick (c.?385 – c.?461), the foremost patron saint of Ireland. #bioinformatics, #genetics, #dna, #research, #genomics, #precisionmedicine, #bullpen, #robustdiagnostics

Sign up for UGenome's Monthly Newsletter to follow UGenome's genomic software product development and latest tools release. #ugenome, #pharmacogenetics, #genomicmedicine, #pharmacogenomics #NVIDIAInception, #bullpen, #ProPEx, #MAXX

It's late for a post. We know. We couldn't get around to publishing this till now. We just had to sleep in to celebrate World Sleep Day. World Sleep Day is an annual event, intended to be a celebration of sleep and a call to action on important issues related to sleep. According to the National Institutes of Health (NIH) in the United States, the cumulative effects of sleep loss and sleep disorders have been associated with a wide range of deleterious health consequences including an increased risk of hypertension, diabetes, obesity, depression, heart attack, and stroke. Get some sleep. We won't notice. ZZZZZZ #ugenome, #pharmacogenetics, #genomicmedicine, #personalizedmedicine, #precisionmedicine, #health, #medicationmanagement

UGenome Value #1 Curiosity. Learners & Teachers. We learn with joy and respect for the complexities of understanding new phenomena. We enjoy sharing and focusing on our audience's needs. As a community of learners and teachers, we encourage teamwork and open communication so people feel free to take risks and make mistakes to effectively leverage our diverse skill sets, talents, and experiences. #ugenome #ugenomeai #ugenomebiotech #bioinformatics #biotech #genetics #science #dna #research #genomics #medicine #immunology #drugdiscovery #datascience #lifesciences #biostatistics #health #pharma #genomeannotation #pharmacogenomics #pharmacogenetics #genomicmedicine #sequencing #dataanalysis #machinelearning #precisionmedicine #metagenomics

Trevor Byrum serves as UGenome AI’s Director of Digital Health, bringing expertise in healthcare technology, business development, and medical device innovation. With a background in medical devices, cardiology, electrophysiology, and radiology, he specializes in digital health solutions that enhance patient care and operational efficiency. An Executive MBA graduate in Entrepreneurship and Software Development Management, Trevor blends strategic vision with hands-on expertise in data analytics, sales operations, and digital transformation. He is a leader who is passionate about market expansion, product innovation, and revenue growth, working to bridge the gap between cutting-edge bioinformatics and clinical applications.

What can UGenome do? https://lnkd.in/g_NtpGtj Contact Jayden Lee, EMBA, PharmD, BCACP for more information. #ugenome, #ugenomeai, #genetics, #pharmacogenomics, #pharmacogenetics, #pgx, #genomicmedicine

World Kidney Day is a global health awareness campaign focusing on the importance of the kidneys and reducing the frequency and impact of kidney disease and its associated health problems worldwide. It's estimated that 14% of Americans suffer from kidney disease and up 90% don't know that they suffer (CDC, 2024). Get screened today. #ugenome, #pharmacogenetics, #genomicmedicine, #personalizedmedicine, #precisionmedicine, #health, #medicationmanagement