Two Sigma Ventures

? Pioneering a New Era in Fertility Treatment ? I am thrilled to announce that Gameto has received FDA clearance to launch our Phase 3 clinical trial for Fertilo - the first iPSC-based therapy to enter this stage since Shinya Yamanaka’s Nobel Prize-winning discovery of induced pluripotent stem cells (iPSCs). This milestone represents a transformative step in our mission to revolutionize #reproductive medicine and improve the #IVF experience. What makes this even more special? Our small but mighty team. ?? This achievement didn’t come easy - it took countless hours, unwavering determination, and #teamwork. Every member of our team poured their heart and soul into this, and this FDA clearance is a testament to their brilliance and passion for transforming #fertility treatment. Why Fertilo Matters: ?? Built on Nobel Prize-winning technology, Fertilo uses iPSC-derived ovarian support cells (OSCs) to mature eggs outside the body, reducing hormone injections by 80% and shortening IVF treatment cycles from 10-14 days to just 2-3 days. ?? Potential to disrupt a multibillion-dollar injection market that has remained unchanged since IVF’s inception, replacing an outdated, difficult process with an innovative, patient-first solution. ?? A safer, less invasive approach - minimizing risks like ovarian hyperstimulation syndrome and reducing the harsh side effects of high-dose hormone treatments. Our Phase 3 trial will launch soon across 15 sites in the U.S., evaluating key outcomes such as embryo development, pregnancy rates, maternal health, and live birth outcomes. Patients struggling with infertility for at least a year will be eligible, with follow-up support for those who do not achieve pregnancy initially. This milestone follows another historic achievement: the world’s first live human birth using Fertilo technology, which took place in December 2024 (https://lnkd.in/gUR_3pZ3). Now, with FDA clearance for our Phase 3 study, we are excited to bring a faster, safer, and more accessible fertility solution to families worldwide. ?? The future of fertility is here. Stay tuned for trial updates and site locations across our channels. Read the Endpoints News article: https://lnkd.in/gHJt-icg #IVF #iPSC #Gameto #ClinicalTrials #WomensHealth #ReproductiveMedicine

Two years ago, I founded SDF Labs with my father Wolfram Schulte and our two phenomenal co-founders Michael Y. Levin and Elias DeFaria. We had a bold vision; to bring deeper SQL understanding, formal reasoning, and static analysis to data development. In other areas of software engineering precise error reporting, dependency tracking, and optimized code generation are powered by advanced tooling grounded in formal semantics. SQL tooling has long been left behind. Our mission has been to bridge that gap and redefine what's possible for SQL developers. I’m beyond excited to share that dbt Labs has acquired SDF Labs! While dbt’s capabilities are so comprehensive as to drive an entire ecosystem, it has historically been limited in one fundamental way:?dbt only understands SQL statements only as a series of strings. Today, that changes. We anticipate bringing the full suite of SDF’s static analysis capabilities, speed, and scalability into the dbt ecosystem. ?? To read more on that, check out Tristan Handy's post here https://lnkd.in/gbYUxj-E I have so many people and institutions to thank for making this possible. Most importantly to the SDF team; thank you for your drive, dedication, and endless creativity. One chapter is closing, but we’re turning the page onto something even brighter, bolder, and more exciting.

For the first WIN/WIN episode of 2025 (which happens to be our 125th episode!) we are joined by Frances Schwiep, Partner at Two Sigma Ventures, who is also a master at systems thinking for anything and everything. Tune in to hear Frances’ evolution of her understanding of risk, the importance of independent thinking, and how she applies it as a leader in the innovation and venture capital industry. Links:? * Apple: https://lnkd.in/e9YYg-za? * Spotify: https://lnkd.in/e8mXSaUu Listen for advice on: * The pros and cons of traditional vs. corporate venture capital? * How women can create their own measuring sticks for success * Creating an equitable and strategic investment decision mechanism? * Ways to understand and engage with new technologies and innovations (such as AI) Zoia Kozakov

TSV portfolio company Distributional was just put on Built In's 2025 best startups to work for remotely (and in SF) list! Perfect time to share that they're hiring for 2 roles ?? Distributional: Building the modern enterprise platform for AI testing to make AI safe, reliable, and secure. 1?? Senior Front End Software Engineer (4+ years of experience, remote) 2?? Senior Full Stack Software Engineer (4+ years of experience, remote) Apply here: https://lnkd.in/e4mgiMDu

I'm proud to be named one of 33 leaders on Forbes Technology Council's Top AI Founders To Watch in 2025. It's an honor to be included among so many other great founders in the field. You can check out the full list here:?https://lnkd.in/gDe8HmQR

Thank you to Alexandra York at Forbes for featuring the news of the first baby born using Gameto's product, Fertilo!?Our investor Dusan Perovic at Two Sigma Ventures and I spoke with Alex to discuss what this breakthrough means for Gameto and the future of the field. Fertilo is an induced pluripotent stem cell (iPSC) derived proprietary solution for IVF and egg freezing that matures eggs outside of the body, using a reduced stimulation protocol that decreases the majority of side effects that are associated with the traditional protocol. Not only is this the first ever live birth using Fertilo, but it also marks the first ever human birth as a result of iPSC technology. Full article here: https://lnkd.in/gtDbGxME

I am thrilled to announce a medical milestone– the world’s first live birth using Gameto’s product, Fertilo, that matures eggs outside the body. On Saturday, December 7th, a healthy baby girl was born in Lima, Peru, after using the Fertilo protocol at our partner clinic Pranor Concebir - Centro de fertilidad. This marks the first ever human birth that occurred as a result of iPSC-derived? technology for egg maturation, and we are excited about the broad implications that Fertilo has on the fields of #IVF and women’s health. Gameto is proud to be a part of innovations that will help more people? achieve their family-building goals. Fertilo is a proprietary solution made from induced pluripotent stem cells (iPSCs) that mature eggs outside the body. By recreating the body’s natural egg maturation process in a dish, using Fertilo shortens the traditional stimulation process of IVF and egg freezing that currently involves 10-14 days? into 2-3 days reducing 80% of hormones given to women and the difficult physical and emotional burden of the treatment. For patients who are interested in using Fertilo, visit our website for more information. Read the full press release here:? https://lnkd.in/gUR_3pZ3

Business banking needed an upgrade. Today it gets one thanks to Dakota! Businesses can now access modern banking that lets you send/receive USD & crypto globally, backed by US Treasuries, with automated yield generation built in. Now you can finally: - Send USD globally via ACH, Fedwire, SWIFT & SEPA - Make borderless payments 24/7 with stablecoins - Keep deposits 100% backed by US Treasuries - Earn automated treasury rewards - Access on-chain yield opportunities Incredible watching this team execute from pre-product investment to launch. Congratulations to the entire Dakota.xyz team!

After nearly 2 years of building and working closely with early customers, we’re excited to share that Dakota is now available to businesses worldwide. While in limited access, hundreds of companies have joined Dakota to send USD globally, manage their treasury, or ensure they stay in control of their assets. Why? Because traditional banking isn’t built for today’s global economy. Transactions are slow, earning yield is complicated, and banks can deny access without warning. Once deposited, your assets are no longer yours—they become a liability on a bank’s balance sheet. Dakota changes that. We’ve built a platform designed for modern businesses. With U.S. Treasuries onchain and crypto infrastructure built for speed and security, we’re helping businesses move faster, stay more secure, and get more out of their money. With Dakota, you can: ? Accept and send USD globally via ACH, Fedwire, SWIFT, and SEPA ??Use stablecoins for instant, 24/7 payments ? Retain full ownership of your assets (no bank balance sheet risk) ??Automatically generate rewards on your balance This is just the beginning. We’re committed to making modern banking tools accessible so businesses can unlock global financial opportunities with tools designed for the modern economy. Businesses worldwide can now sign up at dakota.xyz.

Scent teleportation is here. Games now build themselves in real time as you play. Menopause treatment gets funding to target the source, not symptoms. Osmo teleported scent across their lab & taught computers to smell - first ever working digital olfactory system that can capture & recreate any scent. Plus, their public beta just dropped: imagine any scent in natural language, they'll bring it to life in their lab & send it to you. Etched's Oasis just launched the first fully AI-powered game - generating & running entire playable worlds in real-time, creating new environments as you move. Gameto secured $10M from ARPA-H to advance their menopause program Ameno - moving beyond symptom treatment to address root causes and help women maintain quality of life long-term. TSV portfolio absolutely sprinting into the future over the past week ??