The Journal of Clinical and Aesthetic Dermatology

The management of advanced BCC has been revolutionized in recent years by the development of hedgehog inhibitors (HHIs) and immunotherapies (ie, PD-1 inhibitors). The authors determined that surgery or radiotherapy may not be an option for certain high-risk BCCs due to due to invasion into local tissue, location near anatomically sensitive areas, or metastasis. There is increasing evidence for the efficacy of HHIs, including vismodegib and sonidegib, as the first-line treatment for these advanced BCCs. Despite known efficacy, utility of HHIs can be limited by their adverse event profiles. If patients fail HHIs due to inefficacy or adverse effects, there is evidence for use of the PD-1 inhibitor cemiplimab. Read more: https://ow.ly/3vWY50V6w6m Todd Schlesinger, MD

Despite increasing academic discourse surrounding psychodermatology, few dermatologists or psychiatrists demonstrate a clear understanding of the field. Barriers to physician awareness are double-edged, stemming from both inadequate educational opportunities and patient non-disclosure of psychodermatologic symptoms during clinical encounters. In this article, the authors propose recommendations for pedagogic supplements to be implemented throughout medical, post-graduate, and post-residency education to build familiarity with this subdiscipline and confidence in managing its associated conditions. Read more: https://ow.ly/n8MS50V6s8f Mary Sun, MD

Glycative stress promotes the accumulation of advanced glycation end products (AGEs), impairing extracellular matrix proteins and accelerating skin aging. Rosemary extract has been shown to deglycate AGE crosslink proteins. The safety of a dietary supplement containing rosemary extract (BioR) and its efficacy on skin quality parameters was evaluated over 12 weeks. The randomized, double-blinded, placebo-controlled trial included female participants, aged 40 to 65 years, with moderate-to-severe skin dullness and roughness/texture, and mild-to-moderate erythema, pore size, and uneven pigmentation based on a six-point grading scale. Following 12 weeks of use, a dietary supplement containing rosemary extract and its natural cofactors led to significant mean visible improvements compared to placebo in skin dullness, roughness/texture, erythema, and pore size, and was well tolerated. Read more: https://ow.ly/nc6f50V6vXQ Audrey Gueniche PharmD PhD

A randomized, double-blinded, placebo-controlled trial evaluated a dietary supplement containing rosemary extract (BioR), demonstrating tissular and visible improvements in skin quality. The data reported herein evaluated markers associated with glycative stress and AGEs from skin biopsies and tape strips obtained following dietary supplement use. After 12 weeks, a dietary supplement containing rosemary extract led to significant reductions in a marker associated with oxidative stress, a component of glycation, and AGEs versus placebo in skin in addition to visible improvements in skin quality. Read more: https://ow.ly/rXBf50V6vK6 Audrey Gueniche PharmD PhD

Diego Ruiz Dasilva, MD, FAAD discusses positive results from a recent study published in the Journal of Clinical and Aesthetic Dermatology that assessed the safety and efficacy of JAK inhibitors in a group of elderly patients. Watch here: https://ow.ly/4fKt50Vi8y1

Current research surrounding GLP-1Rs and GLP-1R agonism in dermatology is limited. This review aims to describe the current knowledge of GLP-1Rs and GLP-1RA use in dermatology and suggest future directions. The use of GLP-1RAs have shown promising anti-inflammatory effects and improvement in wound healing, psoriasis, and hidradenitis suppurativa. The literature suggests anti-inflammatory effects of GLP-1RAs may provide direct benefit in the treatment of dermatologic conditions independent of glucose control in addition to indirect improvement via modulation of blood glucose and weight loss. Read more: https://ow.ly/eb1950V6uJZ James Q. Del Rosso, DO Naiem T. Issa, M.D., Ph.D., FAAD Issa, MD, PhD

A retrospective pilot study on a total of eight post-liposuction skin irregularities areas in six women treated with CaHA diluted/hyperdiluted was performed. Efficacy was estimated on pictures of affected areas collected before and four months after treatment, according to the recently validated PLSI scale and Student’s t-test for paired samples was performed to analyze data. Eventual adverse events were used to evaluate safety. The results showed a statistically significant improvement of number and depth of depressions and a trend toward reduction of skin laxity. Read more: https://ow.ly/XjSE50V6v3c Carmen Cantisani Hassan Galadari

Dr. Peter Lio provides a recap from his AAD 2025 session that discusses several alternative approaches to managing itch in patients who are being treated for non-dermatologic cancers. Watch here: https://lnkd.in/eaHvNPND

Dr. Christopher Bunick provides a comprehensive update from his session at AAD 2025 on using antibiotics for the treatment of acne and rosacea, including influences on gut health, antibiotic resistance, and efficacy compared to other acne treatments. Watch here: https://lnkd.in/eFxwjph7

Dr. Daveluy discusses key points from his session at AAD 2025 and?provides tips and guidance for using cryoinsufflation in the treatment of HS. Watch here: https://lnkd.in/em3JxzfD