Target ALS

At Target ALS, we’re continuing to break down barriers in ALS research by expanding our Stem Cell Core, a critical resource providing induced pluripotent stem cells (iPSCs) to scientists worldwide. For a nominal fee and with no IP or data-sharing restrictions, researchers gain access to these human-derived models to study ALS biology, explore genetic mutations, and test potential therapies. iPSCs can be turned into disease-relevant cell types like motor neurons, giving researchers the tools to study ALS in a human-relevant context. This expansion means that scientists will be able to dive deeper into understanding ALS with resources that reflect the genetic diversity of the ALS community, helping to develop targeted treatments and biomarkers. By breaking down barriers to access, Target ALS is empowering the global research community to accelerate the path toward effective therapies and, ultimately, a future where #EveryoneLives. Read more on the expansion: https://bit.ly/402YmU8 #ALSResearch #StemCellScience

For the second year in a row, Lori Berko is taking on the NYC Marathon to raise funds for Target ALS. Though she doesn’t have a direct family connection to ALS, Lori runs in honor of someone who feels like family: Dan Doctoroff, the founder of Target ALS, who is courageously battling the disease. Dan’s unwavering strength, heart, and determination have inspired Lori to join the fight against ALS. "I am grateful for the opportunity to raise money for Target ALS and support my dear friend Dan. Together, we can envision a world where no one dies of ALS,” says Lori. Lori is profoundly thankful for the chance to contribute to this meaningful cause and invites you to join her journey and support Target ALS. Donate today: https://bit.ly/3UezmFJ #EveryoneLives #NYCMarathon #TargetALS #ALSResearch #Fundraiser

We are thrilled to welcome Tammy Sutherns as our new Manager of Mission Communications at Target ALS! Tammy joins us with a strong background in amplifying impactful narratives, and she is inspired by our mission and the dedication of our team. Her expertise will be key in elevating the visibility of our groundbreaking work, ensuring that the remarkable efforts to advance ALS research are recognized and supported. We look forward to the significant contributions she will make as we continue to break down barriers to ALS research and move closer to a world where #EveryoneLives. #TargetALS #ALSResearch #TeamUpdate

We are incredibly grateful to Geoff Greulich for his courage, resilience, and commitment to join the fight against ALS. Diagnosed in 2023, Geoff has chosen to spend his time and energy in a powerful way - by joining us in our mission to break down barriers to accelerate ALS research. He has set an ambitious goal to raise $1 million to support groundbreaking research and critical advancements in finding effective treatments. Geoff’s motto, “Go for the goal,” has guided him throughout his life, and now he’s going all in to help defeat ALS for future generations. Join Geoff and his family by making a gift to Target ALS today, and let’s work together to build a world where #EveryoneLives Click the link to learn more and support Geoff’s campaign: https://lnkd.in/gnKsxZdx #ALSsucks #ALSResearch #DonateNow

At Target ALS, we're committed to addressing the significant disparities in ALS research by prioritizing diversity and inclusion. With only 16% of the global population being of European ancestry but representing nearly 80% of participants in ALS studies, it's clear we need change. Our initiatives focus on increasing outreach and education, providing accessible research options, and expanding our Global Natural History Study internationally. These efforts aim to ensure that all communities are represented in ALS research, driving more comprehensive scientific discoveries and ultimately bringing us closer to a world where #EveryoneLives. Read more on our Global Natural History Study: https://bit.ly/3zInEvV #DiversityInResearch #ALSAwareness #TargetALS

Annie Ratliff Brandt is running the 2024 NYC Marathon with a deeply personal connection to ALS. Four years ago, she lost her father, but his best friend Scott, diagnosed with ALS 15 years ago, continues to inspire her. Despite ALS, her father and Scott never missed their annual hunting and camping trips, finding creative ways to keep their adventures alive. Whether it was her father carrying Scott up a hill or Scott bringing his cane, their friendship and resilience never wavered. When her father became ill, Annie, newly engaged, was unsure who would walk her down the aisle. Scott, in a show of friendship and love, immediately offered to step in if needed. Thankfully, her father was able to walk her down the aisle before he passed away a few months later. Throughout that difficult time, Scott was by Annie and her family's side, sharing stories and memories of her father, offering support, and reminding her of her father’s enduring love. “To honor my dad and my dad’s best friend Scott, I am honored and thrilled to be running the New York City Marathon for Target ALS.” Annie is running to support Target ALS’ mission to break down barriers to ALS research to find effective treatments to realize a world where #EveryoneLives Donate today: https://bit.ly/3BsqXba #NYCMarathon #ALSResearch #Fundraiser #EveryoneLives

Meet Kathryn Morelli, Ph.D., an academic investigator and Assistant Professor at University of Vermont, who received a Springboard Fellowship from Target ALS in partnership with ALS United Greater New York. Dr. Morelli’s research is advancing zinc finger nuclease technology, a gene-editing tool, for potential treatment of c9orf72 ALS. The Springboard Fellowship program supported the transition from her postdoctoral fellowship to her faculty appointment at University of Vermont, leading cutting-edge ALS research. Through Springboard Fellowships, Target ALS aims to support talented scientists at early stages in their careers to foster their interest and encourage new ideas on ALS research, paving the way for tomorrow’s breakthroughs. Thank you to ALS Greater United New York for joining us in supporting Dr. Morelli’s exciting work, exemplifying the radical collaboration needed to accelerate the discovery of new drugs and biomarkers. We are creating a dynamic environment where scientific innovation can thrive, driving us closer to our shared goal: building a future where #EveryoneLives. Read more on the Target ALS Springboard Fellowship here: https://bit.ly/3BAvk41 #RadicalCollaboration #ALSFellowship #TargetALS #ALSResearch #NonprofitPartnerships #BreakingBarriers #ALSUnited

We are thrilled to share that Instituto Roosevelt in Bogotá, Colombia, has enrolled 5 participants within the last month in the Target ALS Global Natural History Study. This milestone reflects our commitment to accelerating ALS research through global collaboration and the inclusion of often underrepresented ethnicities. By emphasizing genetic diversity, we are unlocking deeper insights into the disease's biology and paving the way for targeted therapies that can benefit everyone living with ALS. This study plays a pivotal role in our vision of building a future where #EveryoneLives Learn more about the Target ALS Global Natural History Study: https://bit.ly/3Y2ROSS #ALSResearch #ALS #GlobalNaturalHistoryStudy #Diversity

New Funding Opportunity! Target ALS is excited to announce a new grant opportunity for consortia developing novel modalities as therapeutics for ALS. This funding call for collaborative groups aims to facilitate the discovery and development of molecules targeting RNA/DNA to drive innovation in ALS treatment. What We're Funding: - Development of new antisense oligonucleotide chemistries, CRISPR, Zinc Finger, siRNA, and more. - Enhanced brain delivery platforms like lipid nanoparticles, AAV, and others. - Molecules with demonstrated cell-based activity needing additional validation - Modalities applied to an ALS-associated genetic target Key Dates: LOI due: November 18, 2024 Full proposals due: February 21, 2025 Funding begins: May 2025 This grant is an exciting opportunity to collaborate with academic and industry partners to accelerate breakthroughs in ALS research. Learn more and apply: https://bit.ly/4eQHsMl #ALSResearch #GrantOpportunity #GeneTherapies #InnovativeScience #TargetALS #EveryoneLives

Meet Kylee and Rodney Dial, from Palo Alto, California, who are taking on the TCS New York City Marathon together in support of #TeamTargetALS Their journey with ALS began when they became friends with Jeni and Stephen, another couple expecting a baby at the same time. Stephen, diagnosed with ALS at just 27, was already several years into his battle when they met. Despite the challenges, the two families have shared countless memories together, from watching their little ones grow to cheering on their favorite sports teams. Rodney and Kylee have long dreamed of running the iconic New York City Marathon, and in 2024, their dream will come true as they move to NYC for a year. Their excitement for the race is matched only by their passion for raising money and awareness for ALS, a disease that has deeply touched their lives through their friendship with Stephen. “We felt so lucky to be introduced to Target ALS, an innovative medical research foundation committed to the search for effective treatments for ALS. The opportunity to raise money and awareness for ALS, a disease that plagues one of our closest friends, as we train for and run this race is so meaningful. We cannot wait to cross the finish line in November (with a slice of pizza to celebrate, of course!),” say Rodney and Kylee. Support Rodney and Kylee as they run to create a world where Everyone Lives. Every donation brings us closer to finding effective treatments for ALS: https://bit.ly/4eKxVqo #ALSResearch #NYCMarathon #EveryoneLives #DonateNow