Challenging the traditional view of ketosis, Jonathan Z. Long and team discovered a novel “ketone shunt” pathway, where enzymes attach BHB, the primary ketone body, to amino acids, creating compounds that influence metabolism. This research, supported by the Knight Initiative for Brain Resilience, Sarafan ChEM-H | Stanford University, and Wu Tsai Human Performance Alliance, could rewrite our understanding of how ketosis influences metabolism, including the brain. Learn more: https://lnkd.in/gqiQCETf
Stanford Knight Initiative for Brain Resilience
研究服务
Stanford，California 1,388 位关注者
Harnessing the collective genius of science and breaking free of established dogma to promote brain resiliency.
关于我们
The Knight Initiative for Brain Resilience envisions a world in which our brains remain fit and healthy as we age. We welcome scientists of all stripes, from pathologists to data scientists and beyond, to join our growing, interdisciplinary community focused on the science of resilient brain aging. We are: - Pursuing bold, untried approaches to advance the science of brain aging and resilience - Sharing data, technologies, and know-how to drive progress across the field - Linking fundamental research, human neuroscience, and clinical applications to accelerate the science of brain resilience and our impact on patients - Achieving together what none of us can accomplish alone
- 网站
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https://neuroscience.stanford.edu/brain-resilience
Stanford Knight Initiative for Brain Resilience的外部链接
- 所属行业
- 研究服务
- 规模
- 11-50 人
- 总部
- Stanford，California
- 类型
- 非营利机构
- 领域
- neuroscience、research、neurodegeneration、innovation、brain resiliency、Alzheimer's、Dementia、neurotechnology、interdisciplinary research、healthy cognition、brain aging和neurodegeneration
地点
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主要
获取路线
290 Jane Stanford Way
US，California，Stanford，94305
Stanford Knight Initiative for Brain Resilience员工
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Hülya Torun, Ph.D.
President of Stanford Optical Society | Postdoctoral Scholar at Stanford Neurology & Neurological Sciences | Knight Initiative for Brain Resilience
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Andi Liu
Bioinformatics and genetic epidemiology enthusiast| Climber
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James Haberberger
Data Architect at the Knight Initiative for Brain Resilience
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James Francis Haberberger
Data Architect at Stanford Knight Initiative for Brain Resilience
动态
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Stanford Knight Initiative for Brain Resilience转发了
Congratulations to Jonathan Z. Long and his talented team on this groundbreaking work! We’re thrilled that the Stanford Knight Initiative for Brain Resilience’s could contribute support to understanding the complex pathways behind ketogenic diets and body weight regulation. It’s exciting to see how research like this advances our knowledge of metabolism and can have a profound impact on human health and resilience.
Ketogenic diets and other low-carbohydrate lifestyles have continued to be popular in the last several years, but the chemical pathways that link ketone metabolism with appetite suppression and weight loss have not been completely understood. New research from the lab of Institute Scholar Jonathan Z. Long, led by first author María Dolores Moya Garzón, identifies a new metabolic pathway that helps explain the molecular links between ketogenic diets and body weight regulation. https://lnkd.in/gC_g6Bja Stanford Knight Initiative for Brain Resilience Wu Tsai Human Performance Alliance
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Stanford Knight Initiative for Brain Resilience转发了
Ketogenic diets and other low-carbohydrate lifestyles have continued to be popular in the last several years, but the chemical pathways that link ketone metabolism with appetite suppression and weight loss have not been completely understood. New research from the lab of Institute Scholar Jonathan Z. Long, led by first author María Dolores Moya Garzón, identifies a new metabolic pathway that helps explain the molecular links between ketogenic diets and body weight regulation. https://lnkd.in/gC_g6Bja Stanford Knight Initiative for Brain Resilience Wu Tsai Human Performance Alliance
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Thank you to everyone who attended our Fall 2024 Brain Resilience Symposium and Stanford Neuroscience poster session last week! Save the date for our Winter 2025 Symposium on February 6. Learn more: https://lnkd.in/g_Dk7ypq
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Stanford Knight Initiative for Brain Resilience转发了
It was a great pleasure to attend the Knight Initiative for Brain Resilience Fall Symposium at Stanford University. The incredible testimony of a Huntington's disease patient, amazing talks and a rich poster session. I was also able to share our research project that we're just starting, entitled "Towards rescuing diverse forms of ALS by induction of autophagic flux" through a poster! What a wonderful day full of science and exchange. Looking forward to the next symposium ! Stanford Knight Initiative for Brain Resilience
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Our Brain Resilience Symposium on Progress in Huntington's Disease is today! We look forward to our poster session and talks by Kyan Younes, Michael Hayden, Travis Conley, Susan Ackerman, Steven McCarroll, and Leslie M Thompson.
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Our friends at the Suzanne Pfeffer Lab are hosting the 3rd Annual Cell Biology of Parkinson's Disease Conference on November 11. Speakers include Knight Initiative affiliate Monther Abu-Remaileh on "Lysosomal lipids in Parkinson's." Learn more: https://lnkd.in/gYN6GSgp
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Stanford Knight Initiative for Brain Resilience转发了
The Stanford Knight Initiative for Brain Resilience is thrilled to have contributed support for the Lysosomal Brain Atlas — a resource that will allow researchers to investigate lysosomal proteins implicated in health and disease. Congratulations Julia Heiby (Ori lab) and Ali Ghoochani (Monther Abu-Remaileh lab)!
?? New Publication Alert ?? We are thrilled to announce the release of our Lysosomal Brain Atlas, now available on bioRxiv! This comprehensive resource provides deep insights into the lysosome's role across distinct brain cell types—neurons, astrocytes, microglia, and oligodendrocytes. In this study co-led with Ali Ghoochani, we used cell-type-resolved organelle purification (LysoIP) and high-resolution mass spectrometry to map the lysosomal protein compositions at unprecedented resolution, unveiling novel cell-type-specific functions. A highlight of our work is the identification of SLC45A1 as neuron-specific lysosomal protein and novel regulator of both lysosomal acidity and sugar export. This finding redefines SLC45A1-associated neurological diseases as a new lysosomal storage disorder, opening fresh research avenues into how lysosomal dysfunction contributes to neurological diseases. This atlas is a crucial resource for understanding lysosomal biology and its role in brain diseases, with implications spanning cell biology, neurobiology, genetics, and biochemistry. This work was a collaboration between the Ori Lab at Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) and the Abu-Remaileh Lab at Sarafan ChEM-H | Stanford University. Huge thanks to Alessandro Ori, Monther Abu-Remaileh, Eshaan Rawat, Uche Medoh, PhD, Domenico Di Fraia, Wentao Dong, Marc Gastou, PhD, Kwamina Nyame, Nouf Laqtom and Natalia Gomez-Ospina MD, PhD! We would also like to thank our funding agencies: the NCL-Stiftung, Fritz-Thyssen Foundation, Beatbatten, the NIH Director’s New Innovator Award Program, the Knight Initiative for Brain Resilience at Stanford University, the Chan Zuckerberg Initiative Neurodegeneration Challenge Network, and Aligning Science Across Parkinson’s through the Michael J. Fox Foundation for Parkinson’s Research (MJFF), as well as the German Research Council (DFG) via the Research Training Group ProMoAge. Read the full paper: https://lnkd.in/ehRdHX_c #Lysosomes #CellBiology #SLC45A1 #OrganelleBiology #Neurobiology #Neuroscience #BioRxiv #LysosomalBrainAtlas
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Stanford Knight Initiative for Brain Resilience转发了
Drugs that improve brain metabolism could help Alzheimer’s patients: Targeting a metabolic pathway well-known in cancer research, neuroscientists at Stanford believe they may have found a way to improve brain performance in Alzheimer’s patients. https://lnkd.in/gYTTNTMP
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Stanford Knight Initiative for Brain Resilience转发了
Stanford Medicine neurologist Michael Greicius, MD, has spearheaded a recent groundbreaking genetics study focusing on Alzheimer's disease. This study examines the impact of gene variants, particularly APOE4, on Alzheimer's risk and treatment responses. Greicius's research sheds light on the complexities of Alzheimer's genetics and points towards personalized medicine approaches for treatment development. The study's findings highlight the importance of understanding how gene variants like APOE4 contribute to Alzheimer's disease progression, potentially paving the way for novel treatment strategies. https://lnkd.in/dy8bmtJV
Common gene variant APOE4 offers clues for new Alzheimer’s drug
https://stanmed.stanford.edu