Neurodegeneration, synapse loss, and myelin repair are just a few of the innovative proposals funded by the Knight Initiative through its 2024 Catalyst and Pilot Grant Awards. With $1.24M awarded to 14 interdisciplinary projects, we’re driving bold approaches to tackle the drivers of dementia and uncover mechanisms behind healthy brain aging. Learn more: https://lnkd.in/gR5DSVvi?
Stanford Knight Initiative for Brain Resilience
研究服务
Stanford，California 1,211 位关注者
Harnessing the collective genius of science and breaking free of established dogma to promote brain resiliency.
关于我们
The Knight Initiative for Brain Resilience envisions a world in which our brains remain fit and healthy as we age. We welcome scientists of all stripes, from pathologists to data scientists and beyond, to join our growing, interdisciplinary community focused on the science of resilient brain aging. We are: - Pursuing bold, untried approaches to advance the science of brain aging and resilience - Sharing data, technologies, and know-how to drive progress across the field - Linking fundamental research, human neuroscience, and clinical applications to accelerate the science of brain resilience and our impact on patients - Achieving together what none of us can accomplish alone
- 网站
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https://neuroscience.stanford.edu/brain-resilience
Stanford Knight Initiative for Brain Resilience的外部链接
- 所属行业
- 研究服务
- 规模
- 11-50 人
- 总部
- Stanford，California
- 类型
- 非营利机构
- 领域
- neuroscience、research、neurodegeneration、innovation、brain resiliency、Alzheimer's、Dementia、neurotechnology、interdisciplinary research、healthy cognition、brain aging和neurodegeneration
地点
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主要
获取路线
290 Jane Stanford Way
US，California，Stanford，94305
Stanford Knight Initiative for Brain Resilience员工
动态
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Stanford Knight Initiative for Brain Resilience转发了
Celebrating our Neurology postdocs during National Postdoc Appreciation Week #NPAW2024. As a mentor, Tony Wyss-Coray, PhD finds inspiration watching his postdoctoral scholars find their own path to grow and develop.
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Stanford Knight Initiative for Brain Resilience转发了
Targeting a metabolic pathway well-known in cancer research, neuroscientists at Stanford believe they may have found a way to improve brain performance in Alzheimer’s patients. https://lnkd.in/gYTTNTMP
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The emerging field of synthetic neuroscience aims to leverage the precision tools of synthetic biology — like gene editing, protein engineering, and the design of biological circuits — to manipulate and understand neural systems at unprecedented levels.
Congratulations to the five teams awarded the Synthetic Neuroscience Grants! These interdisciplinary projects aim to advance tools for studying brain circuits at a deeper level. Tackling key challenges that require cross-disciplinary expertise, a total of $1.24M was awarded by Wu Tsai Neuro, Sarafan ChEM-H | Stanford University, and Stanford Bio-X. Learn more:?https://lnkd.in/g7bVKCCA
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Michael Greicius, Stanford Neurologist and Knight Initiative Steering Committee member, discusses the promising future for Alzheimer’s therapies despite skepticism toward the effectiveness of new treatments that target amyloid plaques in the latest episode of "From Our Neurons to Yours." ?? https://lnkd.in/gdPfbTW7
In recent years, Big Pharma has released several new treatments for Alzheimer’s disease that work by clearing the brain of amyloid plaques, sticky protein clumps whose buildup in the brain has defined the disease for decades. But some doctors, like Stanford neurologist Michael Greicius, a member of our steering committee, say they will not be prescribing these amyloid-clearing drugs to their patients. Join us for this week’s podcast episode as Dr. Greicius discusses the promising future of novel therapies for treating Alzheimer’s disease. Listen to the latest episode of “From Our Neurons to Yours” here: https://lnkd.in/gdPfbTW7
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We started the 2024–2025 Brain Resilience Seminar Series with insightful talks from Peter Klein on “Endocannabinoid metabolism as a driver of brain aging” and Scott Dixon on “Exploring the lysosome-ferroptosis axis in cell death and degeneration.” Thanks to the Stanford community for your support—looking forward to the next one!
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Dr. Katrin Andreasson tells NPR about her new study on mice, suggesting that an experimental cancer drug boosted brain metabolism, restored memory, and improved Alzheimer's symptoms. “We expected to see everything [get] much, much, much worse,” she says. “But no, it was the complete opposite.” Read the full story here: https://lnkd.in/gBRAYCaM
This metabolic brain boost revives memory in Alzheimer’s mice
npr.org
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“We were surprised that these metabolic improvements were so effective at not just preserving healthy synapses, but in actually?rescuing?behavior. The mice performed better in cognitive and memory tests when we gave them drugs that block the kynurenine pathway.” -?Katrin Andreasson, Stanford neurologist?
Saunders Family Chair and Professor of Neurology at the Icahn School of Medicine at Mount Sinai
"Among the many ways #AlzheimersDisease may strip away brain function is by disrupting the glucose metabolism needed to fuel the healthy brain. In essence, declining metabolism robs the brain of energy, impairing thinking and memory." Paras Minhas, Jeffrey Jones, Amira Latif-Hernandez, et al. "have zeroed in on a critical regulator of brain metabolism known as the kynurenine pathway." They "hypothesize that the kynurenine pathway is overactivated as a result of #Amyloid plaque and tau proteins that accumulate in the brains of patients with #Alzheimers disease." Here, "they have shown that by blocking the kynurenine pathway in lab mice with Alzheimer’s Disease, they can improve, or even restore, cognitive function by reinstating healthy brain metabolism." Learn More in Science Magazine https://lnkd.in/e72VEr8z Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies - Paras Minhas, Jeff Jones, Amira Latif Hernandez, Melanie McReynolds, PhD, Fred H. Gage, Katrin Andreasson, et al. Stanford Knight Initiative for Brain Resilience at Stanford’s Wu Tsai Neurosciences Institute Stanford University School of Medicine Salk Institute for Biological Studies Keio University Kyoto University (京都大学) Princeton University Huck Institutes of the Life Sciences, Penn State University University of California, San Francisco Banner Sun Health Research Institute SciTechDaily https://lnkd.in/erUXSwAs
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Stanford Knight Initiative for Brain Resilience转发了
Our NeURO and NeURO-CC poster session was a success! Thank you to the Wu Tsai Neuro community for supporting our undergrad neuroscience fellows and learning about their projects. #neuroscience #stanford #research
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Stanford Knight Initiative for Brain Resilience转发了
A new study in the journal Science finds that drugs developed for cancer therapy restore disordered glucose metabolism in Alzheimer’s models, and may have promise for treatment! “We were surprised that these metabolic improvements were so effective at not just preserving healthy synapses, but in actually rescuing behavior. The mice performed better in cognitive and memory tests when we gave them drugs that block the kynurenine pathway,” said senior author Katrin Andreasson, a neurologist at Stanford University School of Medicine and also a #CZBiohubSF Investigator. Read about it here ?? https://lnkd.in/eveKUcbB #science #neuroscience #Alzheimers
Drugs that improve brain metabolism could help Alzheimer's patients
neuroscience.stanford.edu