Last Day at ACS Spring 2025 – Visit Booth #3951 ! It’s the final day of the ACS Expo, and we have a special offer for attendees! Stop by Booth #3951 to: ? Claim a 2-Month Free Evaluation Trial of SILCS technology for structure-based drug design. ? Get 3-Molecule Credit for free on the CGenFF Web App—accelerate your force field parameterization! Don’t miss this chance to explore SILCS-powered insights for molecular modeling, binding site analysis, and ligand optimization. ?? Find us at Booth #3951 before the Expo ends! Or contact us at silcsbio.com #ACSSpring2025 #CompChem #SILCS #DrugDesign
SilcsBio
制药业
Baltimore，Maryland 1,095 位关注者
SilcsBio provides software and services for unlocking the full potential of computer-driven drug design.
关于我们
SilcsBio provides software and services for unlocking the full potential of computer driven drug design. Our algorithms for mapping proteins will provide you with a level of detail you have never before experienced. From our highly accurate free energy maps to conformational nuances revealing hidden pockets of opportunity, you will discover a whole new world of possibilities. Our main products are: SILCS (Site-Identification by Ligand Competitive Saturation): provides sophisticated chemical functional group mapping for proteins and other biological targets, yielding 3-D maps and quantitative data to assist in ligand design and optimization. Possible applications include: Database Screening, Ligand, Optimization, Fragment-based Ligand Design, and Pharmacophore Generation. Single Step FEP: Single Step free Energy Perturbation allows free energy calculations 1,000 times faster than with standard FEP. Evaluate thousands of ligand modifications per hour without compromising accuracy. CGenFF: The CHARMM General Force Field program generates comprehensive parameters and topology information for a wide range of drug-like molecules,.allowing their use in Computer-Aided Drug Design campaigns.
- 网站
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https://silcsbio.com/
SilcsBio的外部链接
- 所属行业
- 制药业
- 规模
- 2-10 人
- 总部
- Baltimore，Maryland
- 类型
- 私人持股
- 创立
- 2012
- 领域
- drug design、computer-aided drug design、software development和computational chemistry
地点
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主要
获取路线
1100 Wicomico St
US，Maryland，Baltimore，21230
SilcsBio员工
动态
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SilcsBio at #ACS Spring 2025 – Talk & Poster Details! We’re excited to present at ACS Spring 2025 in San Diego! Here’s where you can find us: #Talk: Leveraging Site Identification by Ligand Competitive Saturation (SILCS) technology towards antibody-drug conjugate development ?? Speaker: Asuka Orr ?? Date: Sunday, March 23, 2025 ?? Session: Computational Approaches to Optimizing Antibody-Drug Conjugates ? Time: 4:30 PM - 4:55 PM ?? Room: Hall F Room 1 – San Diego Convention Center #Poster: Overcoming the Trade-off Between Speed and Accuracy in Computer-Aided Drug Design ?? Presenter: Abhishek Kognole ?? Date: Tuesday, March 25, 2025 ?? Session: COMP Poster Session ?? Poster Board #: 865 ? Time: 7:00 PM - 9:00 PM ?? Location: Hall B2/C – San Diego Convention Center ??#Booth 3951 Visit us at the Expo — let’s connect and discuss how SILCS can advance your drug design campaign! Oliver Tao will be there to give you a tour. Looking forward to engaging with the community. See you in San Diego! #ACSSpring2025 #CompChem
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?? ACS Spring 2025 is almost here! The SilcsBio team is excited to attend in San Diego! ?? We’ll be at the Expo with a booth, plus we have a talk and a poster session lined up. Come meet us to discuss how SILCS-based technologies are advancing computational drug discovery! Stay tuned for more details on our schedule. If you’re attending, let’s connect! ?? #ACSSpring2025 #CompChem #CADD #DrugDiscovery
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?? Recording Available: SILCS v2025 Release Webinar! Missed the live session? Catch up now and explore: ?? Enhanced SILCS-MC Docking – Improved precision with new features. ?? ML-Powered Hotspot Analysis – Smarter and more accurate predictions. ?? Streamlined Simulations & Enhanced GUI – Smoother workflows and usability improvements. ?? Click link below to watch the recording! ?? Read the full release notes here: https://lnkd.in/dTj8zPPZ #CompChem #CADD #DrugDiscovery
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Reminder to Register! Join us on Feb 13 for an in-depth look at SILCS v2025.
?? Join Us for the SILCS v2025 Release Webinar! ?? Discover the latest updates in SILCS v2025, transforming computer-aided drug design (#CADD) with enhanced precision, flexibility, and usability. Key highlights include: ? More precise docking with new SILCS-MC features like water molecule inclusion. ? Improved hotspot ranking using ML-based SILCS-Hotspots. ? Streamlined SILCS simulations for complex systems with multiple cofactors . ? Easier project management with upgraded GUI. ?? Don’t miss the opportunity to see these features in action and learn how they can accelerate your drug discovery projects. #CompChem #DrugDiscovery
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?? Join Us for the SILCS v2025 Release Webinar! ?? Discover the latest updates in SILCS v2025, transforming computer-aided drug design (#CADD) with enhanced precision, flexibility, and usability. Key highlights include: ? More precise docking with new SILCS-MC features like water molecule inclusion. ? Improved hotspot ranking using ML-based SILCS-Hotspots. ? Streamlined SILCS simulations for complex systems with multiple cofactors . ? Easier project management with upgraded GUI. ?? Don’t miss the opportunity to see these features in action and learn how they can accelerate your drug discovery projects. #CompChem #DrugDiscovery
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?? Webinar Recording Now Available! ?? Our recent webinar, "SILCS-WATER: Accounting for the Role of Water in Protein-Ligand Binding", was a resounding success! ?? A huge thank you to our speakers, Anmol Kumar and Alexander MacKerell , for their insightful presentation on this extension of the SILCS-MC docking approach. SILCS-WATER provides exciting possibilities for understanding water's role in protein-ligand interactions and advancing drug design. ??? Missed it or want to revisit the highlights? Watch the recording here: https://lnkd.in/eiK8CB3u #CompChem #DrugDesign #SILCS
SilcsBio Invited Webinar : SILCS-WATER Accounting for the Role of Water in Protein Ligand Binding
https://www.youtube.com/
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Great to see the SILCS technology in action!
????Our open access paper on identifying putative allosteric binding sites on 7 distinct class A GPCRs is now published ????We report these in detail for adenosine A1 receptor, β2-adrenergic receptor, chemokine receptor CXCR2, dopamine receptor D1, free fatty acid receptor FFA1, M2 muscarinic acetylcholine receptor, and active/inactive conformers of the delta-opioid receptor. It was again a great collaboration with Alexander MacKerell & SilcsBio and kudos to Tu??e ?nan, PhD and Merve YüCE ???????? https://lnkd.in/d79_-eUj
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Looking for SILCS-Covalent Beta Testers! We’ve recently developed a new covalent workflow module aimed at enhancing covalent drug discovery. You can view our publication here: https://lnkd.in/e_pfyimd This module utilizes the SILCS method to not only identify reactive nucleophilic residues but also evaluate warhead groups and drug-like molecules for covalent drug development. We’re currently looking for beta testers. If interested, reach out to [email protected] for more information and incentives we can offer.