Seraphina Therapeutics

Today's coverage from Longevity Technology https://lnkd.in/gChPjubu

An exciting new clinical trial was just published in The Journal of Nutrition supporting that @fatty15 can treat nutritional C15:0 deficiencies and reverse Cellular Fragility Syndrome. Cellular Fragility Syndrome, caused by low C15:0 levels, is the first nutritional deficiency syndrome to be identified in over 75 years. Studies support that Cellular Fragility Syndrome may be present in as many as 1 in 3 people, leading to accelerated aging and onset of aging-related conditions. The good news is that C15:0 nutritional deficiencies can be easily identified and treated. This randomized, double-blinded, and placebo-controlled trial included young adults (18 to 24 years old) and was led by UC San Diego. Here are key findings from this important study: 1) 2 out of 3 study participants had C15:0 levels that met the criteria of nutritional C15:0 deficiency, 2) fatty15 safely and significantly raised C15:0 blood levels, and 3) those who achieved nutritionally sufficient C15:0 blood levels had clinically relevant evidence of reversing Cellular Fragility Syndrome, including improved liver function and red blood cell health. Go, science. Check out NutraIngredients coverage of this latest clinical trial!

Twelve years ago, a new form of cell death was discovered by a team of researchers at Columbia University. It’s called ferroptosis. Over 10,000 scientific papers have been published on ferroptosis, and we now know that it can accelerate aging, type 2 diabetes, heart disease, and fatty liver disease. The cause of ferroptosis has remained unknown. Until now. As published in?Metabolites, a new nutritional C15:0 (pentadecanoic acid) deficiency syndrome has been discovered. Cellular Fragility Syndrome is the first nutritional deficiency syndrome to be discovered in 75 years and may be affecting as many as 1 in 3 of us. This paper is a culmination of 12 years of studies that explain C15:0’s role as an essential fatty acid, how low C15:0 levels results in cellular fragility, ferroptosis and impaired health, and most importantly, how replenishing our C15:0 levels fixes our cells, reverses ferroptosis, and restores metabolic, liver, and heart health. Population wide declines in C15:0 levels have been occurring due to 1) lower intake of whole dairy-fat foods (our primary source of C15:0, 2) lower C15:0 content in dairy due to changing agricultural practices, and 3) aging - our C15:0 levels naturally decline as we get older. The good news is that nutritional deficiency syndromes are detectable and fixable. It’s time to revisit nutritional guidelines and agriculture industry practices to get C15:0 back into our lives. Read the study:?https://lnkd.in/gDtfHMHr