Sengenics

?? ?? ?????? ?????????????? ?????? ??????????????????! ?? We’re thrilled to announce that ?????????????????? ???? ?????? ???????? ???? ???????????????? ????????????????! For years, our KREX? technology has set the standard in precision antibody profiling. Now, as part of Standard BioTools, KREX has been added to their SomaScan? suite of solutions, creating a powerful, complementary portfolio. Together, we’re enabling researchers to achieve ???????????? ???????????????? and make ????????????, ???????? ?????????????????? ?????????????????????? in the field of proteomics. At Sengenics, we’ve always been passionate about advancing science and innovation, and we’re excited to continue this mission as part of the Standard BioTools family. The future of ‘?????????? ???? ?? ??????????????’ just got even brighter, and we’re honored to be part of this transformative journey. ?? Stay tuned for what’s ahead as we work together to push the boundaries of discovery! #Proteomics #Biomarkers #PrecisionMedicine #Multiomics

?? ???????????? ??????????????-???????? ???????????????? ???????? ???????????? ???????????????????? ???????? ?????? ???????? ?????????? ??????????! Discover the groundbreaking role of anti-cytokine autoantibodies (ACAAs) in health, disease, and treatment. ACAAs—naturally occurring antibodies targeting immune-regulating proteins—are emerging as powerful players in immune health, with implications for predicting disease severity, guiding vaccine development, and even advancing cancer therapies. Our white paper, "????????-???????????????? ???????????????????????????? ???? ????????????, ??????????????, ?????? ??????????????????," dives deep into: ? The role of ACAAs in balancing immune responses and reducing harmful inflammation. ? How ACAAs are linked to various diseases, including autoimmune disorders, infections, and cancer. ? Cutting-edge applications in precision medicine, from antibody profiling to targeted therapies. ?? ?????? ???????????? ???????? ????????? If you're a researcher, clinician, or biotech professional interested in immune regulation, personalized medicine, or the latest advancements in therapeutic antibodies, this paper is for you! ?? ?????? ???????? ???????? ???????? ??????????! https://lnkd.in/ex-SNWZf #Cytokines #Immunology #PrecisionMedicine #TargetedTherapy #CancerResearch #Biomarkers

?? Catch the Latest in Lupus Research at ?????? ?????????????????????? ????????! ?? Systemic lupus erythematosus (SLE) presents unique diagnostic challenges, with current markers often falling short. On ???????????????? ???? ???? ??:???? ???? (Washington, DC, USA), Dr. Ioannis Parodis, MD, PhD, senior consultant rheumatologist at Karolinska University Hospital, will discuss new findings from a broad screen of IgG and IgA autoantibodies utilizing our ??-??????? ?????????????????? ?????????????? ????????????????????. ?? ?????? ???????? ???????????????? ??????????????: A biomarker with exceptional sensitivity and specificity was identified, surpassing traditional markers like anti-dsDNA and anti-Sm in differentiating SLE from other autoimmune diseases and healthy controls. This highlights the power of autoantibody profiling in advancing SLE diagnostics. We’re thrilled to see our technology supporting such impactful research! ???????????????????????? ??????????: "IgG and IgA anti-LIN28A Outperform Anti-dsDNA and Anti-Sm in Distinguishing SLE from Health and Other Autoimmune Diseases“ Learn more: https://lnkd.in/eVem3R24 #ACR24 #SLE #Lupus #Autoimmunity #Biomarkers #Rheumatology

?? ?????????????????? ????????????????????????????????????? ???? ?????????????????????????? In a recent breakthrough study led by ????. ???????????? ?????? at UKM Medical Molecular Biology Institute (UMBI) and Universiti Kebangsaan Malaysia (UKM), autoantibodies (AAbs) were identified as being differentially expressed in the serum of grade IV glioblastoma patients compared to healthy controls (?? < 0.05). Among the most upregulated were anti-COL4A3BP and anti-HSP90AA1, revealed using Sengenics’ i-Ome? Discovery protein microarray. ?????? ???????? ???????? ????????????? These findings suggest that AAbs could serve as minimally invasive biomarkers for glioblastoma diagnosis or treatment, offering exciting new avenues for therapeutic targets. Larger-scale studies are needed to validate this AAb signature. ?? Read the full study to explore the data and implications in “Immunotherapy” (Taylor & Francis Group): https://lnkd.in/etAbmDbB #CancerResearch #Glioblastoma #Biomarkers #Autoantibodies #PrecisionMedicine #Immunology #Oncology

?????? ?????? ???????????? ???????????????????? ???? ?????????????? ??????????????????????? Our latest white paper, "Address Key Challenges in Vaccine Development with Antibody Profiling," dives deep into the complexities of vaccine design and demonstrates how antibody profiling can streamline every stage of the process. Here’s what you’ll discover: ? ?????? ?? ???????????????????? ???? ?????????????? ?????????????????????? and practical strategies to overcome them ? How ???????????????? ?????????????????? can enhance efficacy, safety, and patient targeting ? How ?????????????????? ?????????????? ?????????????????????? enable precise, high-throughput antibody analysis, providing insights critical to vaccine success ?? ?????????? ???????????????? ???????? ?????? ???????????? ????????????????. Download your copy of this white paper now: https://lnkd.in/ePfmWnQX #VaccineResearch #VaccineDevelopment #DrugDevelopment

?? Exciting Moments from Biomarkers US 2024! ?? We've had an incredible time connecting, learning, and exploring groundbreaking science at #BiomarkersUS2024. From insightful conversations at our booth to Dr. Iryna Voloshyna's inspiring talk on using Sengenics KREX? technology to identify autoantibody biomarkers of checkpoint inhibitor-mediated toxicity, it’s been a conference to remember. Thank you to everyone who joined us—whether for a quick chat or a deep conversation. If you haven’t stopped by yet, there’s still time! Come visit us at ?????????? ???before you go! We’re leaving Biomarkers US 2024 more motivated than ever to advance our work and support the collaborations that drive this field forward. Until next time! #Biomarkers #Immunology Oxford Global

?? ???????? ?? ???????? ???????? ???? ?????????? ???????? ?? ?????? ???????????? ???? ???????????? ?????????????? ????????????????! ?? Next Wednesday, join ????. ???????? ??????????, Associate Dean, Professor, and Director at NYU Grossman School of Medicine, for an exclusive webinar on ?????????????? ????, where she will delve into the cutting-edge world of autoantibody profiling to uncover predictive signatures of response and toxicity of immune checkpoint inhibitors (ICIs) in melanoma patients. ?? Don’t miss this rare chance to ask Dr. Osman your questions during the ???????? ??&?? following her presentation! ?? ????????????: Live Webinar ?? ????????: Wednesday, October 30 ?? ????????: 8 AM PDT / 11 AM EDT / 4 PM CET While the presentation centers on cancer autoantibody biomarkers, it offers valuable insights for anyone interested in the transformative potential of antibody profiling in the broader field of medical research. ?? ???????????????? ??????????: https://lnkd.in/euQrdkZX #CancerResearch #Biomarkers #ImmunoOncology #ICIs #ImmuneCheckpointInhibitors #Oncology #irAEs #Immunology #Melanoma

?? ???????? ????. ?????????? ?????????????????? ???? ???????????????????? ???? ????????! On October 28, 2024, at 12:00 PM, Dr. Iryna Voloshyna, Senior Research Scientist from NYU Grossman School of Medicine, will present her research on ???????????????????????????? (????????) ???? ???????????????????? for predicting immune checkpoint inhibitor (ICI)-mediated toxicity. ?? What you’ll learn: ? ?????? ???????????????? ???????? ?????? ???????????????????? to predict immune-related adverse events with ICI. ? ?????? ?????????????????? ???????????????????? for predicting treatment outcomes and ICI-induced toxicity. ? ?????????????? ???? ???????????????????????? ???????? ???? ?? ?????????????????? ?????????? ?????????? to evaluate the contribution of AAbs to ICI-mediated toxicity. ? ?????????????? ???? ?????? ???????????????? identified and validated using Sengenics protein microarrays. ?? ??&?? ?????????????? ???????? ????. ??????????????????: 12:25-12:50 PM & 2:00-4:00 PM in Sengenics BOOTH 2 ?? Event info: https://lnkd.in/et98MkTn #BiomarkersUS2024 #Immunology #CancerResearch #CheckpointInhibitors #ICIs #Biomarkers

?? ?????? ???????????????? ???????? ????????????: ???????????????????????????? ?????? ?? ???????? ?????????????????????? ?? Autism Spectrum Disorder (ASD) affects approximately 1 in 100 children worldwide, yet many of its biological mechanisms remain elusive. Exciting new research highlights the immune system's role in ASD and offers potential pathways for improved diagnosis and treatment. ?? In a study led by ????. ?????????? ??. ????-???????????????? from Hamad Bin Khalifa University and the Qatar Biomedical Research Institute - QBRI, plasma antibodies from children were profiled using the Sengenics i-Ome? Discovery protein microarray, while peripheral B cells were analyzed via flow cytometry. ?????? ????????????????: ? Identified ???????????????????????????? ?????????????????? ???????????????????????????? between children with severe ASD and those with mild-to-moderate ASD, some of which correlated with maternal age and birth weight. ? Revealed dysregulated ?? ???????? ??????????????????????, including increased frequencies of activated naive B cells in ASD. ? Observed disrupted ???????? ??????????????????, potentially contributing to B cell dysfunction in ASD. ? Developed an ??-???????????????????????? ?????????? with a ROC-AUC of 0.937, demonstrating high accuracy for classifying ASD severity. This study highlights the immune system's critical role in ASD and marks a significant step toward understanding the molecular complexity of the disorder. It also opens new doors for more accurate diagnostic tools. ?? Read the full study in ???????????? ???????????????? (September 2024): https://lnkd.in/eX2sRxHD How could these findings on autoantibodies and B cell dysfunction shape the future of diagnostic tools for ASD? #ASDResearch #Neurodevelopment #Immunology #BCells #AutismScience #Biomarkers #PrecisionMedicine International Society for Autism Research, INSAR

Achieving a ???????????????????? ???????????????????? ?????????????????? isn't just about the biomarkers themselves — it ???????????? ???????? ?? ????????-???????????????? ??????????. Here are some key considerations: ? Research aims that address a clinical need ? Appropriate sample size for statistical power ? Samples aligned with research objectives ? Ensuring cohort homogeneity to minimize variability At Sengenics, our bioinformatics experts offer end-to-end support, from robust study design to advanced data analysis, ensuring the discovery or validation of meaningful antibody biomarkers. Learn how Sengenics is defining the science of antibody analysis for biomarker discovery and validation: https://lnkd.in/gva82yDi #Biomarkers #Bioinformatics #StudyDesign #Autoantibodies #PrecisionMedicine #Immunology #BiomedicalResearch #ClinicalResearch #DrugDiscovery #BiomarkerDiscovery #TranslationalResearch