Science of Lives

?? ?? ?? Paper of the Day ? ? ? Bamboo-inspired ultra-strong nanofiber reinforced composite hydrogels The document describes the development of a bamboo-inspired ultra-strong nanofiber-reinforced composite hydrogel. The key points are:- The hydrogel is designed based on the hierarchical structure and molecular interactions found in bamboo. It uses self-assembled chitosan-sodium alginate nanofibers (CSNFs) as the reinforcing component, tannic acid (TA) as the interfacial crosslinker, and poly(vinyl alcohol) (PVA) as the hydrogel matrix.- The strong interfacial electrostatic interactions and hydrogen bonding between the CSNF, TA, and PVA components lead to simultaneous improvements in strength (up to 13.8 MPa) and stretchability (up to 500%) compared to pure PVA hydrogel.- Further alignment of the composite through stretch-induced orientation increases the strength to 48 MPa with 470% strain, and up to 60.2 MPa with 250% strain when fixed in a salt solution. The bamboo-inspired hierarchical design and synergistic molecular interactions enable the hydrogel to exhibit excellent mechanical properties, including high strength, toughness, and impact resistance, making it suitable for applications in demanding mechanical environments. #BambooInspiredHydrogels #NanofiberReinforcement #MolecularInteractions #HierarchicalAssembly #StretchOrientedStructure #ImpactResistance #HighStrength #HighStretchability #BottomUpDesign #BioinspiredMaterials #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Paperoftheday #POD Date: 26/02/2025 For more, click the link below? https://lnkd.in/gJJuyQ9X

?? ?? ?? Paper of the Day ? ? ? Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness The paper of the day focuses on mouse blastocyst development, particularly how epiblast cells and primitive endoderm cells sort themselves within the inner cell mass. In early development, an embryo must sort its cells correctly to form different tissues. Understanding this helps scientists study developmental disorders and improve lab-grown embryos for research #Embryodevelopment #cellsorting #cellfatespecification #tissuepatterning #blastocyst #innercellmass #embryonicpatterning #morphogenesis #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Paperoftheday #POD Date: 25/02/2025 For more, click the link below https://lnkd.in/gkqCDcZ7

?? ?? ?? Paper of the Day ? ? ? Size-controlled assembly of phase separated protein condensates with interfacial protein cages The Paper of the Day article describes a method for assembling stable protein condensates using interfacial protein cages. The researchers used various protein cages with different sizes and oligomeric states to stabilize protein condensates formed through liquid-liquid phase separation (LLPS). They found that the size and binding strength of the protein cages are crucial for effectively stabilizing the condensates without causing excessive cage penetration. The researchers were able to control the size of the condensates by tuning the ratio of condensate proteins to cage proteins. They also demonstrated that the cage-stabilized condensates can selectively recruit and encapsulate client biomolecules like DNA and antibodies. Additionally, the researchers used cryo-electron tomography to visualize the structural features of the cage-stabilized condensates, showing that the cages form a monolayer on the condensate surface. #ProteinCondensates #PickeringEmulsion #SurfaceStabilization #ProteinCages #LiquidLiquidPhaseTransition #CryoElectronTomography #DynamicBehaviors #ClientRecruitment #SizeControl #CellularPenetration#Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Paperoftheday #POD Date: 24/02/2025 For more, click the link below? https://lnkd.in/ggYpquHY

?? ?? ?? Paper of the Day ? ? ? A light-driven device for neuromorphic computing The Paper of the Day discusses the development of a unique optoelectronic synaptic device that leverages the negative photoconductance property of a single-crystal material called Cs2CoCl4. This device exhibits simultaneous volatile resistive switching response and sensitivity to optical stimuli, making it a promising candidate for optically enhanced neuromorphic applications. The device can perform synaptic functions such as potentiation and depression through electrical and optical stimuli, and it can also be used as a light-tunable artificial neuron that operates via frequency modulation. The authors highlight the potential of this device for applications in artificial intelligence, machine vision, and neuro-robotics, as well as for other uses beyond neuromorphic computing. The work offers a fresh perspective on exploring new materials and strategies for developing optoelectronic devices with cognitive abilities. #NeuromorphicComputing #OptoelectronicDevices #ResistiveSwitching #Photoconductance #Cs2CoCl4 #ArtificialSynapses #ArtificialNeurons #VolatileSwitching #OpticalStimulation i#NeuromorphicApplications #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Paperoftheday #POD Date: 17/02/2025 For more, click the link below? https://lnkd.in/gcDmuxVd

?? ?? ?? Paper of the Day ? ? ? A foundation model of transcription across human cell types The Paper of the Day introduces the General Expression Transformer (GET) model, which is designed to accurately predict gene expression in both seen and unseen cell types by learning transcriptional regulatory syntax from chromatin accessibility data across 213 human fetal and adult cell types. GET outperforms previous state-of-the-art models in identifying cis-regulatory elements and identifying upstream regulators of fetal hemoglobin. The model also provides rich cell-type-specific regulatory insights, including identifying potential motif-motif interactions and constructing a structural interaction catalogue of human transcription factors and coactivators. The article demonstrates GET's ability to adapt to different sequencing platforms and assay types, as well as non-physiological cell types like tumor cells. #TranscriptionalRegulation #ChromatinAccessibility #CellTypeSpecificity #FoundationModel #GeneExpression #CisRegulatoryElements #TranscriptionFactors #ProteinInteractions #LentiMPRA #FinetuningTransfer #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Paperoftheday #POD Date: 17/02/2025 For more, click the link below? https://lnkd.in/gA6zwhUe

?? ?? ?? Paper of the Day?? ? ? High-sensitivity, high-speed, broadband mid- infrared photodetector enabled by a van der Waals heterostructure with a vertical transport channel The document describes the design and performance of a high-sensitivity, high-speed, and broadband mid-infrared photodetector based on a graphene/black phosphorus/molybdenum disulfide/graphene (Gr/BP/MoS2/Gr) vertical heterostructure. The key advantages of the vertical device design include: Vertical transport channel: The minimized vertical channel length of tens of nanometers prevents recombination-induced charge carrier losses during transport, leading to high external quantum efficiency. Graphene electrodes: The use of transparent graphene electrodes enables spatial overlap of the junction region with the electrodes, establishing a vertical channel without impeding the transmission of incident light. The high carrier mobility of graphene ensures swift extraction of charge carriers to the external circuit. #VanDerWaalsHeterostructure #VerticalTransportChannel #MidInfraredPhotodetector #HighSensitivity #HighSpeed #UltrabreadBandDetection #RoomTemperatureOperation #LowPowerConsumption #CMOSCompatibility #PerformanceOptimization #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Paperoftheday #POD Date: 12/02/2025 For more, click the link below? https://lnkd.in/gV4EAb5b

?? ?? ?? Paper of the Day?? ? ? Site-saturation mutagenesis of 500 human protein domains The document describes a study that generated a comprehensive dataset of deep mutational scans for over 1,000 human protein domains, called the "Human Domainome 1" dataset. The key points are: The study used a multiplexed assay called aPCA to measure the effects of saturation mutagenesis on the in vivo abundance and stability of human protein domains. This allowed them to generate sequence-to-stability maps for a large number of domains. The data showed that the effects of mutations on protein stability are largely conserved across homologous domains, allowing the authors to fit thermodynamic models that can predict stability changes for entire protein families. The abundance data was used to identify evolutionary functional sites in the protein domains, many of which were not previously annotated. The stability data was used to analyze the contribution of protein stability to the pathogenicity of clinical variants, showing that destabilizing mutations are enriched in pathogenic variants. #DNA?#RNA #aPCA #protienbinding #proteinstability #pathogenicity #assay #mutagenesis #GeneticPerturbations #ComputationalBiology #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Paperoftheday #POD Date: 10/02/2025 For more, click the link below? ?https://lnkd.in/gBxWM7EN

?? ?? ?? Paper of the Day ? ? ? ?rGO-Aluminium Substrates as Broad-Spectrum Antimicrobial and Antibiofilm Functional Materials The paper of the day from advanced materials interfaces talks about antibiofilm and antimicrobial activity of electro-chemically deposited reduced graphene oxide on aluminum substrates. To overcome limitations of aluminium such as microbial contamination and corrosion the reduced graphene oxide is used. The surface hydrophobicity of rGO-Al promotes a stable interaction with the microbes. As a 2 D material rGO has better conductive and antimicrobial properties which can be used in biological application. In this paper the Graphene oxide is converted to reduce Graphene oxide by electrochemical method due to the removal of oxygen containing surface groups. #sol #pod #friday #wiley #online #library #review #advanced #materials #interfaces? #microbial #Anti #graphene #reduced #oxide #ecoli #grampositive #bacteria #phathogens. Date: 07/02/2025 For more, click the link below? https://lnkd.in/gsJuAmRQ

?? ?? ?? Paper of the Day ? ? ? Transition from irrigation with untreated wastewater to treated wastewater and associated benefits and risks The paper of the day reviews the shift from irrigation with untreated wastewater to treated wastewater, analyzing the benefits, risks, and necessary mitigation strategies. The study highlights that wastewater treatment improves health and environmental safety, also it introduces challenges such as soil carbon loss, pollutant release, and potential reductions in crop yields. A holistic and sustainable management of wastewater and wastewater irrigated soils within the interconnected cycles of water, carbon, nutrients, and other elements, requires an integrated assessment of multiple goals in addition to SDG 6 “Clean water and sanitation”. #Wastewaterirrigation #Treatedwastewater #Waterreuse #Agriculturalsustainability #Pathogencontamination #Antibioticresistance #Heavymetalaccumulation? #Soilsalinization #Nutrientcycling #Environmentalrisks #Researcharticle #Openaccess #SOL #Scienceoflives #Paperoftheday #POD Date: 13/02/2025 For more, click the link below? https://lnkd.in/gvD2xYyA

?? ?? ?? Paper of the Day?? ? ? Unravelling the Epitaxial Growth Mechanism of Hexagonal and Nanoporous Boron Nitride: A First-Principles Microkinetic Model The Paper of the Day study investigates the adsorption, diffusion, and dehydrogenation of borazine on the Ru(0001) surface using density functional theory. Borazine preferentially adsorbs with the nitrogen atom on top of the surface Ru atom. Diffusion occurs via a pivoting motion between HCP and FCC sites, with a high energy barrier. Dehydrogenation is kinetically favored from boron atoms but thermodynamically favored from nitrogen atoms. Partial dehydrogenation leads to the formation of dimers and trimers, with meta-connected structures being more stable. These intermediate structures can further polymerize to form nanoporous hBN networks. The findings provide insights into the growth mechanism of hBN on Ru(0001) surfaces. #borazine #adsorption #diffusion #dehydrogenation #DFT #Ru(0001) #hBN #growth #morphology #polymerization #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Paperoftheday #POD Date: 05/02/2025 For more, click the link below? https://lnkd.in/gNZpS2qB