#Researcharticle Revolutionizing Cancer Care: New Genetic Tool Predicts Chemotherapy Side Effects Before Treatment Begins! A groundbreaking pharmacogenetic tool, the ANTIBLASTIC DRUG MULTIPANEL PLATFORM, has been developed to predict chemotherapy side effects based on a patient’s genetic profile. Validated in non-small-cell lung cancer (NSCLC) patients, this tool helps oncologists personalize treatment by assessing the risk of adverse drug reactions (ADRs) before therapy begins. Using bioinformatics analysis of 326 genetic variants (SNPs), patients are categorized into five genetic clusters, allowing for safer and more effective chemotherapy choices. This innovative platform has applications beyond oncology, enabling anyone to understand their genetic predisposition to chemotherapy-related toxicity before ever developing cancer. Developed by experts from ASL Taranto, IRCCS Gemelli Hospital, Sbarro Health Research Organization at Temple University, and SG Moscati Hospital, this research marks a major step in precision oncology. The blog is based on research led by Dr. Concetta Cafiero, with contributions from Prof. Raffaele Palmirotta, Prof. Salvatore Pisconti, Dr. Luciano Giacò, Prof. Antonio Giordano, and Dr. Canio Martinelli. With further validation and a mobile app in development, this tool could transform personalized medicine, making cancer treatments safer and more effective. A breakthrough in precision medicine—tailoring cancer treatments with genetic insights! To read more, click on the blog link: https://bit.ly/3QCq3gr www.drantoniogiordano.com | www.shro.org Antonio Giordano Newswise Giancarlo Arra Temple University Università di Siena Temple University College of Science and Technology #PrecisionOncology #GeneticTesting #PersonalizedMedicine #Chemotherapy #CancerTreatment #Pharmacogenetics #OncologyCare #CancerResearch #MedicalInnovation #Bioinformatics #GeneticProfiling #HealthcareTechnology #ADRs #CancerCare #FutureOfMedicine #SHRO?
Sbarro Health Research Organization
生物技术研究
Philadelphia,PA 9,284 位关注者
We specialize in research aimed at finding cures for diseases by identifying their underlying molecular mechanisms.
关于我们
The Sbarro Health Research Organization is a nonprofit charity committed to funding excellence in basic genetic research to cure and diagnose cancer, cardiovascular diseases, diabetes and other chronic illnesses and to foster the training of young doctors in a spirit of professionalism and humanism. SHRO researchers have completed research on new technologies designed to diagnose lung, ovarian, endometrial, breast and brain tumors as well as lymphomas. Their work with gene therapy has also led to new strategies to treat tumors of the lung and brain, and has led to over twenty patents. SHRO is dedicated to supporting scientific research aimed at finding cures for cancer, cardiovascular and other diseases by identifying their underlying molecular mechanisms. SHRO includes the Sbarro Institute for Cancer Research and Molecular Medicine located at Temple University in Philadelphia, PA and an SHRO affiliated laboratory located at the University of Siena in Siena, Italy. Over 200 SHRO molecular biologists, geneticists, physicists, and chemists work to develop new methods to understand, diagnose and cure disease. In 1993, Antonio Giordano, M.D., Ph.D., founded the Sbarro Institute with a generous donation from Mario Sbarro, the Founder of the Sbarro restaurant chain, following Dr. Giordano’s discovery of the tumor suppressor gene pRb2. Initially named the Sbarro Institute, the research center was located at Thomas Jefferson University, where Dr. Giordano was a professor. When Dr. Giordano moved to Temple University in 2002, he and twenty fellow scientists forged a new, three-year alliance with Temple University in Philadelphia, Pennsylvania. Under the new arrangement, the original Sbarro Institute was renamed the Sbarro Health Research Organization, Inc. (SHRO), which includes the Sbarro Institute for Cancer Research and Molecular Medicine at Temple and the SHRO-affiliated laboratory at the University of Siena in Siena, Italy.
- 网站
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https://www.shro.org/
Sbarro Health Research Organization的外部链接
- 所属行业
- 生物技术研究
- 规模
- 11-50 人
- 总部
- Philadelphia,PA
- 类型
- 非营利机构
- 创立
- 1993
- 领域
- research、cancer、molecular medicine、precision medicine、biotechnology、microbiology、genetics、genomics、neuroscience、pharmaceuticals、international research collaboration、science、medicine和education
地点
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主要
1900 N 12th Street
US,PA,Philadelphia,19122
Sbarro Health Research Organization员工
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James J. Vincenzo
Operations, finance, advisor, mentor, business strategy, executive, revenue enhancement, cost containment, stakeholders.
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Andrew Douglas
President at Douglas Consulting/ A Jay Douglas Photography
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Enrico Bucci
Adjunct Professor at Temple University
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Filippo Surace
Founder & CEO @Cube Labs | Owner & CEO @Gruppo Surace
动态
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Sbarro Health Research Organization转发了
An Important Step Forward in Precision Oncology: New Genetic Tool Predicts Chemotherapy Side Effects Before Treatment Begins https://lnkd.in/gqaeKU7x Antonio Giordano Sbarro Health Research Organization Temple University #PersonalizedTherapy #Cancer #healthcare #cancertherapy #tumor
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February is Gallbladder and Bile Duct Cancer Awareness Month. These rare cancers, affecting the gallbladder and bile ducts, often go undiagnosed until advanced stages, making awareness vital. In 2024, an estimated 12,350 people will be diagnosed, and 4,530 will lose their lives to these diseases. Symptoms like jaundice, abdominal pain, and weight loss can be easily overlooked. By raising awareness, we can encourage early detection, better prevention, and support for vital research into more effective treatments. Let’s unite in the fight against these cancers and work toward improving outcomes for those affected. www.drantoniogiordano.com | www.shro.org Antonio Giordano Giancarlo Arra Temple University Università di Siena Temple University College of Science and Technology #GallbladderCancer #CancerAwareness #KnowTheRisks #EarlyDetection #TakeAction #HealthCheck #StayInformed #PreventCancer #GallbladderHealth #SpreadAwareness #SHRO #AntonioGiordano #Cancercure
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Sbarro Health Research Organization转发了
#BlogPost The European Court of Human Rights has ruled that the Italian government is at least partially responsible for the environmental and health crisis in the “Land of Fires” in southern Italy, caused by illegal chemical waste dumping. Dr. Antonio Giordano, a prominent researcher and advocate, criticizes the government for its inaction, calling it a "silent massacre." He emphasizes that health is a constitutional right and urges immediate action, including environmental cleanups, strict regulations, and severe penalties for polluters. Giordano, who first exposed the crisis in his investigative book, warns that further delays will cost more human lives. To read more, click on the blog link. English: https://bit.ly/3XaV92m Original blog : https://bit.ly/4bd3dWn www.drantoniogiordano.com | www.shro.org Antonio Giordano Newswise Giancarlo Arra Temple University Università di Siena Temple University College of Science and Technology #EnvironmentalCrisis #LandOfFires #Italy #HumanRights #Pollution #HealthRisk #EnvironmentalJustice #EcoDisaster #SaveOurPlanet #StopPollution #ActNow #ClimateAction #ToxicWaste #PublicHealth #CleanEnvironment #SHRO
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Sbarro Health Research Organization转发了
The U.S. Surgeon General raises awareness about the link between alcohol consumption and cancer risk. Temple biology professor Antonio Giordano shares his insights on the connection. Read more:
Surgeon general warns: Alcohol is an ignored cancer risk
news.temple.edu
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#BlogPost The European Court of Human Rights has ruled that the Italian government is at least partially responsible for the environmental and health crisis in the “Land of Fires” in southern Italy, caused by illegal chemical waste dumping. Dr. Antonio Giordano, a prominent researcher and advocate, criticizes the government for its inaction, calling it a "silent massacre." He emphasizes that health is a constitutional right and urges immediate action, including environmental cleanups, strict regulations, and severe penalties for polluters. Giordano, who first exposed the crisis in his investigative book, warns that further delays will cost more human lives. To read more, click on the blog link. English: https://bit.ly/3XaV92m Original blog : https://bit.ly/4bd3dWn www.drantoniogiordano.com | www.shro.org Antonio Giordano Newswise Giancarlo Arra Temple University Università di Siena Temple University College of Science and Technology #EnvironmentalCrisis #LandOfFires #Italy #HumanRights #Pollution #HealthRisk #EnvironmentalJustice #EcoDisaster #SaveOurPlanet #StopPollution #ActNow #ClimateAction #ToxicWaste #PublicHealth #CleanEnvironment #SHRO
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We Are Hiring! Postdoctoral Researcher The Sbarro Institute for Cancer Research and Molecular Medicine at Temple University is seeking a Postdoctoral Researcher to join our team starting July 1, 2025. Focus: Molecular characterization of RB family tumor suppressors (RBL1/p107, RBL2/p130) in breast, mesothelioma, and bladder cancer, plus studies on novel RBL2 interactors. Requirements: Ph.D. in Molecular Biology, Cancer Biology, or related field Experience in cancer research & molecular biology techniques Apply Now: Send CV & cover letter to: [email protected], [email protected] #Hiring #Postdoc #CancerResearch #TempleUniversity #SHRO #joinourteam
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#BlogPost Understanding the Overlooked Cancer Risk of Alcohol The U.S. Surgeon General, Vivek Murthy, has issued an advisory highlighting that less than half of Americans recognize alcohol as a cancer risk. Alcohol consumption is the third leading preventable cause of cancer in the U.S., following tobacco and obesity, and is linked to at least seven types of cancer. Biology professor Antonio Giordano explains that alcohol is classified as a known human carcinogen, primarily due to its toxic metabolite, acetaldehyde, which causes DNA mutations and increases cancer risk. The advisory suggests updating warning labels on alcoholic beverages to raise awareness. Additionally, research shows that both regular and binge drinking elevate cancer risk, reinforcing the need for informed decision-making regarding alcohol consumption. To read more, click on the blog link. English: https://bit.ly/4bcRCqg www.drantoniogiordano.com | www.shro.org Antonio Giordano Giancarlo Arra Temple University Università di Siena Temple University College of Science and Technology #CancerAwareness #HealthRisk #AlcoholAndCancer #SurgeonGeneral #PublicHealth #PreventCancer #HealthyChoices #Wellness #KnowTheRisk #StayInformed #Cancercure #Cancerrisk #SHRO #molecularcancer?#Antoniogiordano #templemade
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A meaningful moment for SHRO at Sanremo 2025 – #HUMANOMA We were honored to present Humanoma in the literary lounge of Casa Sanremo, sharing a story that intertwines science, culture, and innovation. A special highlight was meeting Minister of Health Orazio Schillaci, who recognized our work and the importance of raising awareness about environmental and health issues. Our director, Prof. Antonio Giordano, for his nomination to the Ministry of Health’s Environment and Health Committee—a crucial step in the fight for public health protection. The recent European Court of Human Rights ruling on Terra dei Fuochi reinforces why our research and advocacy matter. Science has a voice, and through Humanoma, we continue to amplify it, ensuring that the impact of environmental pollution is neither ignored nor forgotten. A heartfelt thanks to Casa Sanremo, Mea Edizioni, Viridiana Myriam Salerno, journalist Maurilio Giordana, and the press for helping share this story. This is more than a book—it’s a movement. www.drantoniogiordano.com | www.shro.org Carlo Fumo Giancarlo Arra Temple University Università di Siena Temple University College of Science and Technology #Sanremo2025 #Humanoma #SHRO #ScienceForChange #HealthAndEnvironment #PublicHealth #EnvironmentalAwareness #Innovation #ResearchMatters #CasaSanremo #MeaEdizioni #TerraDeiFuochi #ScienceAndCulture #FutureOfHealth #Antoniogiordano #Carlofumo
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This Valentine’s Day is a time to celebrate love, and this year, let’s also spread awareness for World Congenital Heart Defect Awareness Day (February 14) shines a light on the resilience of children born with congenital heart defects (CHD) and their families. These defects are structural issues present at birth that can affect the heart's chambers, valves, and blood vessels, often requiring surgery and constant care. While challenging, this day highlights incredible advancements in CHD treatment, improving survival rates and offering hope for a long, fulfilling life. It also raises awareness about the need for early detection, as timely diagnosis and intervention can significantly improve outcomes. It is also a call to action, encouraging us to support research and awareness. Nearly 1 in 110 babies in the U.S. are born with CHD, and innovations in medical devices like heart valves and pumps are transforming their care. By spreading awareness, we can help increase funding for CHD research and ensure that more children have access to life-saving treatments. World CHD Day celebrates both scientific progress and the emotional strength of these families, reminding us that by coming together, we can make a difference in the lives of children living with congenital heart defects. Let’s unite to raise awareness, www.drantoniogiordano.com | www.shro.org Antonio Giordano Giancarlo Arra Temple University Università di Siena Temple University College of Science and Technology #CHDAwarenessDay #CongenitalHeartDefects #TinyHeartsMightySpirits #HeartHealth #CHDResearch #HeartWarriors #EarlyDetectionSavesLives #WorldCHDAwarenessDay #CongenitalHeartDefectAwareness #HeartHealthMatters #SHRO #Cancercure #Celltheraphy #Awarenesspost
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