Rupa Health

Excited to announce we are kicking off an educational series on Metabolic Health with Dr. Casey Means, MD (who is not just a brilliant physician, but an incredible human as well! ??) on Rupa Health! Most people know Rupa as the platform for doctors that makes lab testing simple. But we’ve always been focused on so much more — especially, education. In just the last few years, tens of thousands of healthcare practitioners have gone through Rupa’s live classes and courses. Around half a million people read our educational content each month. And we’ve had over 10M downloads of our Root Cause Medicine Podcast. ?? In any growing market, education is key, but in this one, it’s truly critical. The world is waking up. Millions of patients want more root cause, holistic, whole person care — not just symptom treatment. And they’re looking for practitioners who can help. The more practitioners we can educate about how to use and understand advanced testing to get to the root cause, the more patients we can ultimately get healthier. The stakes are high — conversations about the metabolic health crisis we’re in as a country are on the national stage right now. And Dr. Casey Means, MD is one of the leading voices for our nation. Her book, Good Energy, has hit #1 on both Amazon and the New York Times Bestseller lists. And this is just the beginning.??? I couldn’t be more excited to host her on the Rupa platform. Join us for a?Live Class with Dr. Casey?on?Friday, October 11th at 9AM PST / 12 PM EST, where she’ll walk through pioneering a movement focused on?preventing?chronic disease through advanced diagnostics and lifestyle-based interventions. RSVP here: https://lu.ma/dr.means

Come join us for a Live Class on October 11th to learn from Dr. Casey Means live!!!!

Mapping the Connection Between Periodontal Disease and Cardiovascular Health The link between gum disease and heart health might seem surprising, but research suggests a strong connection. Exploring how periodontitis influences cardiovascular disease (CVD) can open new pathways for prevention and treatment strategies, emphasizing the need for integrated healthcare approaches. About the Study: This study conducted a comprehensive bibliometric analysis to explore the association between periodontal disease and cardiovascular disease (CVD). Researchers examined 3,447 articles from 98 countries, published between 2003 and 2022, using the Web of Science database. Advanced tools like VOSviewer, CiteSpace, and the R software package “bibliometrix” were employed to analyze research trends, collaborations among authors, and key knowledge areas. These tools functioned like precision instruments, allowing for detailed visualization and understanding of vast data sets. The University of Helsinki and the University of North Carolina were notable contributors to the research output. The analysis identified major research hotspots, such as the "oral microbiome," "inflammation," and "Porphyromonas gingivalis." These terms represent critical areas of focus in understanding the link between periodontitis and CVD. The study highlighted a significant increase in publications over the analyzed period, reflecting growing interest and advancements in this research field. The detailed mapping provided insights into the evolving landscape of research, illustrating the interconnectedness and collaborative efforts within the global scientific community. Key Findings of the Study: Periodontal disease potentially increases the risk of cardiovascular events, with notable contributions from the United States, Japan, and China. The Journal of Periodontology emerged as the most popular publication venue. Authors like Pussinen and Tonetti significantly influenced the field. The study underscored the critical roles of the oral microbiome (the community of bacteria in the mouth) and inflammation in linking periodontitis to CVD, noting a strong correlation between these factors and heightened cardiovascular risks. Key Takeaways: The comprehensive bibliometric analysis underscores the growing recognition of the link between periodontal disease and cardiovascular health. The study emphasizes the importance of integrating dental care into broader healthcare strategies to mitigate cardiovascular risks.

Dietary Factors and Hypertension: A Genetic Perspective High blood pressure, or hypertension, is a global health concern closely linked to cardiovascular disease. Using cutting-edge Mendelian randomization, researchers have uncovered how specific dietary habits directly cause or prevent hypertension. This approach helps reveal the true impact of our food choices on blood pressure. About the Study: The main goal of this study was to uncover the causal relationships between specific dietary factors and the risk of developing high blood pressure, or hypertension. By understanding which foods can raise or lower blood pressure, the researchers aimed to provide clear dietary recommendations to help people manage and prevent hypertension more effectively. To achieve these objectives, the researchers used genetic data to determine how different foods affect blood pressure, rather than just observing people's diets and health outcomes. This approach helps to eliminate the usual biases found in observational studies, offering more accurate and reliable results. The researchers gathered data on 16 different dietary factors from large genome-wide association studies (GWAS), including alcohol consumption, meat intake, and the consumption of vegetables, fruits, cheese, and cereals. They compared this genetic data with information from the FinnGen Study, which included over 350,000 participants of European descent, allowing for a detailed comparison. By examining genetic markers that indicate a person's likelihood to consume certain foods and comparing these markers to their blood pressure data, the researchers pinpointed which dietary habits were likely causing changes in blood pressure. This innovative approach provided clear, actionable insights into how different foods impact the risk of hypertension. Key Findings: The study found that higher alcohol and meat consumption significantly increased the risk of hypertension, with weekly alcohol intake raising the risk by 53%, frequent alcohol intake by 20%, poultry intake by 225%, and beef intake by 80%. Conversely, consuming protective foods like salad/raw vegetables, dried fruits, cheese, and cereal reduced the risk of hypertension by 42%, 49%, 38%, and 35%, respectively. Takeaways: Key dietary habits, such as alcohol consumption and intake of certain meats, increase hypertension risk, while the consumption of raw vegetables, dried fruits, cheese, and cereals appears protective. These insights can guide dietary recommendations for hypertension prevention and management.

Garlic: A Natural Agent for Managing Blood Sugar and Cholesterol Levels Garlic, long celebrated for its culinary and medicinal properties, may offer significant benefits for blood sugar and cholesterol management. A systematic review and meta-analysis published in Nutrients sheds light on how garlic consumption can positively impact these vital health parameters. Study Summary: The review encompassed data from 22 studies, involving a total of 1,567 participants including a diverse group of men and women, aged 18 to 80, from various countries, including Canada, Iran, Pakistan, India, the United States, and others. Researchers conducted an extensive review of randomized controlled trials to evaluate garlic's effects on key health indicators including fasting blood glucose (FBG, which indicates blood sugar levels after fasting), glycosylated hemoglobin (HbA1c, which shows long-term blood sugar control over approximately three months), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C, often referred to as "good" cholesterol), low-density lipoprotein cholesterol (LDL-C, known as "bad" cholesterol), and triglycerides (TG). These indicators were crucial in assessing the overall impact of garlic on both blood sugar and lipid profiles. By analyzing these specific metrics, the researchers aimed to provide a clear picture of how garlic supplementation could benefit metabolic health. Findings: The levels of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) significantly decreased. Conversely, high-density lipoprotein cholesterol (HDL-C) levels increased significantly, while triglyceride (TG) levels remained within the typical range, unaffected by garlic intake. Key Takeaways: Garlic has proven beneficial in managing blood sugar and cholesterol levels, making it a valuable addition to dietary interventions aimed at improving metabolic health. However, its effect on triglycerides remains inconclusive. There's a need for further research to standardize dosages and formulations of garlic.

Hidden Health Risk: Toxic Metals in Tampons Tampons, a staple in menstrual hygiene, might carry hidden health risks due to toxic metal contamination. Research has revealed the presence of harmful metals in these everyday products, raising concerns about potential long-term health impacts for those who use them regularly. Study Summary: In 2024, a study examining the concentrations of 16 metals in 30 different tampon brands, purchased from the US and Europe was published in Environment International. The study aimed to understand how different tampon characteristics, such as organic versus non-organic materials, and the region of purchase, influenced metal content. Researchers used inductively coupled plasma mass spectrometry (ICP-MS) to measure metal concentrations, analyzing both the inner absorbent core and outer covering of each tampon. They found significant variations in metal concentrations based on tampon type and region of purchase. Findings: The study detected measurable levels of all 16 metals in the tampon samples. Notably, lead was found at a geometric mean concentration of 120 ng/g, cadmium at 6.74 ng/g, and arsenic at 2.56 ng/g. Zinc showed the highest concentration, with a geometric mean of 52,000 ng/g. The geometric mean concentration is an average that better represents typical values by reducing the impact of unusually high or low numbers. Differences were noted between organic and non-organic tampons, with non-organic tampons having higher lead levels, while organic tampons showed higher arsenic levels. Takeaways: This study highlights the need for stricter regulations and routine testing of tampons for metal content to ensure consumer safety. The detection of toxic metals like lead, which has no safe exposure level, in commonly used menstrual products highlights potential health risks. Future research should focus on the bioavailability of these metals when tampons are used and their long-term health effects.

Gut Microbiota Reveals New Diagnostic Pathways for Autism Research has identified unique markers in the gut microbiota that could transform the diagnosis and understanding of Autism Spectrum Disorder (ASD). These findings open up promising avenues for non-invasive diagnostic tools. Overview of the Study: The study aimed to explore the associations between the gut microbiome and ASD, focusing on bacteria, archaea, fungi, and viruses. Researchers conducted a detailed analysis of the gut microbiome using metagenomic sequencing (comparable to creating a comprehensive map by analyzing every detail carefully) on fecal samples from 1,627 children, aged 1 to 13 years, including both ASD and neurotypical children. Advanced DNA sequencing techniques and machine learning algorithms were employed to identify and analyze a wide range of microorganisms and their functions within the gut microbiome. This comprehensive approach allowed researchers to identify specific microbial markers and metabolic pathways that differ between children with and without ASD. By integrating these data, the researchers were able to highlight significant differences in the gut microbiomes of children with ASD compared to neurotypical children. Key Findings: The study found that 14 archaea, 51 bacteria, 7 fungi, 18 viruses, 27 microbial genes, and 12 metabolic pathways were significantly altered in children with ASD. These findings suggest that gut microbiota markers have substantial potential as diagnostic tools for ASD. The Takeaway: The study highlights that analyzing gut microbiota markers shows promise as a non-invasive diagnostic tool for Autism Spectrum Disorder (ASD), revealing distinct microbial and metabolic differences. This could lead to earlier, more accurate diagnoses and pave the way for innovative treatments tailored to the unique gut profiles of individuals with ASD.

The Impact of Cheese Consumption on Cardiovascular Health Cheese, often seen as an indulgence, might actually benefit heart health. Research explores the potential protective effects of cheese against various forms of atherosclerosis (AS) and atherosclerotic cardiovascular diseases (ASCVD). These findings could revolutionize dietary guidelines for preventing heart-related complications. The Study Breakdown: This study utilized a two-sample Mendelian randomization (MR) analysis to explore the causal relationship between cheese consumption and the risk of developing AS, ASCVD, and their complications. Researchers analyzed data from genome-wide association studies (GWAS) to avoid overlap between participating populations, ensuring comprehensive results. Advanced statistical methods like random-effects inverse-variance-weighted analysis, Cochran's Q statistic, and MR-Egger intercept tests, which function like a detailed inspection toolkit for ensuring accuracy and reliability in findings, were used to validate results. This analysis provides a strong theoretical foundation for incorporating cheese into dietary management strategies to combat cardiovascular diseases. What Did They Find? The study found that higher genetically predicted cheese consumption was associated with lower risks of various types of atherosclerosis and ASCVD complications. Specifically, it reduced the risks of coronary artery disease, angina pectoris, myocardial infarction, heart failure, ischemic stroke, peripheral artery disease, and cognitive impairment. The protective effects were not observed for cerebrovascular AS, arrhythmia, and cardiac death. These findings highlight the potential benefits of cheese in cardiovascular health management. The Key Takeaways: This research highlights the potential cardiovascular benefits of cheese consumption. By leveraging genetic data, the study provides compelling evidence that incorporating cheese into a balanced diet may help reduce the risk of several serious heart conditions. This insight opens new avenues for dietary recommendations aimed at preventing atherosclerotic cardiovascular diseases.

Social Media Use and Adolescent Mental Health: Insights from a US Study The widespread use of social media has raised concerns about its impact on mental health, especially among adolescents. This study delves into how different levels of social media use affect the mental health of adolescents, providing crucial insights into this growing issue. Summary of the Study: This population-based study utilized data from the 2022 National Youth Tobacco Survey, encompassing 23,366 US middle and high school students aged 11–18. Mental health was assessed using the Patient Health Questionnaire-4 (PHQ-4), and social media use was categorized by frequency. Researchers used multinomial logistic regression, which categorizes different types of data into clear groups to identify patterns and correlations, helping them determine the link between social media use and mental health issues. Additionally, they employed a finite mixture Poisson model, similar to uncovering hidden structures within complex datasets. This method enabled them to identify distinct subgroups of adolescents based on their mental health status, providing detailed insights into how social media use affects various mental health conditions. The study identified significant differences in mental health outcomes based on social media use and sexual identity. This detailed analysis highlighted the complex and varied effects of social media use on different adolescent subgroups, emphasizing the need for targeted mental health interventions. Significant Findings: The study found a consistent link between frequent social media use and poor mental health. Two latent groups emerged: one with minimal mental health issues and another with significant indicators. Frequent social media users in both groups exhibited worse mental health outcomes. Sexual minorities, especially bisexual students, were more likely to report poor mental health. The findings highlight the varied impacts of social media use on different adolescent subgroups. Implications for Mental Health Interventions: The study emphasizes the need for targeted mental health interventions considering the varying impacts of social media use on different youth subgroups. Integrating these insights into mental health strategies can help address the unique challenges faced by frequent social media users and sexual minority adolescents.

The Impact of Periodontitis on Diabetes Complications Diabetes is a complex disease, and managing it requires paying attention to more than just blood sugar levels. Research highlights how gum disease, specifically periodontitis, can significantly impact diabetes complications. This connection emphasizes the need for comprehensive healthcare that includes dental care to improve overall outcomes for diabetic patients. Study Overview: Conducted in Sweden, this comprehensive study spanned over a decade, from 2010 to 2020. The study analyzed data from 28,801 individuals with type 1 diabetes (T1D) and 251,645 with type 2 diabetes (T2D), compared with matched non-diabetic controls. Participants were monitored for periodontitis, defined by the presence of at least three teeth with probing depths of 6 mm or more. The study also assessed diabetes-related complications such as retinopathy (eye disease), albuminuria (a condition where excess protein is found in the urine, indicating kidney damage), stroke, ischemic heart disease (a condition characterized by reduced blood flow to the heart), and mortality rate alongside socioeconomic factors, glycemic control, and demographic data. Researchers employed multiple logistic regression models to estimate the prevalence and risk ratios of periodontitis in diabetic versus non-diabetic groups. They also used Poisson regression models to evaluate the incidence rates of tooth loss, similar to tracking the frequency of an event over time, and Cox regression analyzes to explore the impact of periodontitis on diabetes-related complications, much like examining the ripple effects of a single event across a larger system. This extensive, long-term study provided valuable insights into the complex relationship between diabetes, gum health, and overall well-being. Key Findings: Periodontitis was more prevalent in individuals with T2D (22%) compared to non-diabetic individuals (17%), with younger age groups showing the most significant differences. In T1D, periodontitis prevalence was higher especially among those with poor glycemic control. Gender differences were also noted, with males generally exhibiting higher rates of periodontitis than females. Additionally, periodontitis was linked to increased risks of retinopathy and albuminuria in both T1D and T2D patients, but not to stroke, cardiovascular disease, or higher mortality rates. Important Insights: This study highlights the crucial role of gum health in managing diabetes complications. Incorporating dental care into diabetes management strategies could significantly improve patient outcomes, particularly for those with poor glycemic control.