ROME Therapeutics

Thank you to all speakers, panelists, poster presenters, and in-person and virtual attendees for making this the biggest and most insightful #DarkGenomeSymposium to date! We’re so proud of how far the #DarkGenome field has advanced in a few short years. Thank you to our co-hosts Enara Bio, Nucleome Therapeutics, and NYU Langone Health for the collaboration, hard work, and fun along the way. And thank you to our sponsors for supporting this important exchange of information to benefit human health and pioneer a new frontier in biology and medicine. Until next year! #DGS2024

We’re closing out the 3rd annual #DarkGenomeSymposium with a keynote address: “Drugging the #DarkGenome: Lessons from HIV Reverse Trancriptase.” We’re honored to have Eddy Arnold, PhD – Board of Governors Professor and Distinguished Professor, Department of Chemistry and Chemical Biology, and the Center for Advanced Biotechnology and Medicine, Rutgers University – with us to share his insights! #DGS2024

We appreciated all of today’s short talks from selected #DGS2024 posters! We saw promising data in #ParkinsonsDisease, #RheumatoidArthritis, and #Cancer. Thanks to all presenters! ?? Sarah Knutson, PhD Senior Director, Early Discovery, ROME Therapeutics ?? Chantal Hargreaves, PhD Principal Scientist, Immunology, Nucleome Therapeutics ?? Yonghao Liang (Holden),?Graduate Student, Wang Lab, Washington University in St. Louis ?? Joana Senra, PhD,?Director, Preclinical Validation, Enara Bio

The final #DarkGenomeSymposium panel discussion will discuss: “Are Dark Antigens the Key to Off-The-Shelf Approaches for Next-Generation Immuno-Oncology Targets?” #DGS2024 Panelists: ?? Joseph Dukes, PhD ?? Peter Johannes Holst, MD, PhD ?? Rom Leidner, MD ?? Santosh Vardhana, MD, PhD ?? Bhardwaj Nina, MD, PhD?(moderator)

Thank you to the Session 4 #DGS2024 presenters for sharing your insights on the promise of #DarkGenome approaches in immuno-oncology! #TranslationalMedicine #CancerResearch #DarkGenomeSymposium

The fourth and final session of this year’s #DarkGenomeSymposium is kicking off now! Erwei Song, Daniel De Carvalho, PhD, Abhijeet Pataskar, and session chair Sophie Papa will discuss immuno-oncology and the #DarkGenome. #DGS2024

At yesterday evening’s #DarkGenomeSymposium poster session, we debuted the first data in #NeurodegenerativeDisease for our LINE-1 reverse transcriptase (RT) inhibitors. Congratulations to Sarah Knutson, PhD, Senior Director of Early Discovery at ROME, on this poster’s selection for a short talk at the #DGS2024 podium! Learn more about the therapeutic potential of LINE-1 RT inhibitors in #ParkinsonsDisease: https://lnkd.in/eV9ettJG #DarkGenome

The next #DarkGenomeSymposium panel will discuss the question: “Is the #DarkGenome an instigator or innocent bystander in autoimmunity and neurodegeneration?” Looking forward to further illumination of this next frontier in biology and its potential role in challenging diseases. #DGS2024 Panelists: ?? Cristopher Bragg, PhD ?? Douglas Nixon, MD, PhD ?? Sophie Parmentier-Batteur, PhD, PharmD ?? Perron Hervé, PhD ?? Mike Dybbs, PhD (moderator)

Fantastic presentations from the #DGS2024 Session 3 speakers elucidating the potential of #DarkGenome therapeutic approaches in a range of #AutoimmuneDiseases and #NeurodegenerativeDiseases. Thank you for sharing your research! #DarkGenomeSymposium #TranslationalMedicine #Lupus #Alzheimers

"When we put this meeting together, we wanted to combine the basic science and translation -- developing therapies to ultimately benefit patients." -Heike Keilhack, Chief Scientific Officer, ROME #DGS2024 #DarkGenome #DarkGenomeSymposium #DrugDevelopment #TranslationalMedicine