PROVE Network

Right Ventricular Injury Definition and Management in VV-ECMO Given the alarmingly high-mortality observed in critically ill patients necessitating advanced lung support and a rapid upsurge in utilization of ECMO support for respiratory failure, there is an urgent need for the frontline intensivist to understand the pathophysiology of Right Ventricular Injury in these high-risk patients. This PRORV (https://www.prorvnet.com) review in ASAIO (https://lnkd.in/dJxxKrix) accompanies our recent PRORV and PROVE Network (https://lnkd.in/dWinRK4z) Delphi study in ICM (https://lnkd.in/dnWSciMD). Interested in full copies of these papers? Contact us. #PRORV #PROVENetwork #PROVE #ICU #ECMO #RV #RightVentricle #ScopingReview image: SEBASTIAN KAULITZKI / SCIENCE PHOTO LIBRARY / Getty Images

Sedation Practices in Mechanically Ventilated Neurocritical Care Patients — a secondary analysis of the ENIO study In a post hoc analysis of neurocritically ill patients with acute brain injury requiring invasive mechanical ventilation, initial sedation practices did not significantly affect IMV duration, but patients started on midazolam had longer ICU stays, with variations in sedation choices between high-income and middle-income countries. Read our analysis in Neurocritical Care: https://lnkd.in/dqAnUNaW ENIO, a PROVE Network observational study (https://lnkd.in/dsgxvdb2). #PROtectiveVEntilationNetwork #PROVE #ENIO #AcuteBrainInjury #ABI #ICU #outcome #sedation

Exploring the Mechanical Power of Ventilation in Non-ARDS Patients Laura Buiteman-Kruizinga’s latest analysis of the wizARDS database (https://lnkd.in/dYy_mcRM) highlights airway pressures and respiratory rates as key drivers of MP. Lowering the respiratory rate could be a promising strategy to achieve lower MP. Further research is needed to validate these findings: … PERMISS! (https://lnkd.in/dgRYvz5u). Laura Buiteman-Kruizinga for the PROVE Network in Anesthesia: https://lnkd.in/dBfWgQvn #AmsterdamUMC #PROVENetwork #IntensiveCare #ICU #MechanicalVentilation #MechanicalPower #MP #TidalVolume #RespiratoryRate #DrivingPressure

Epidemiology, Ventilation Management, and Outcomes in Invasively Ventilated COVID-19 Patients Siebe Blok’s analysis of the PRoVENT-COP database (https://lnkd.in/dshwG9Kq) shows significant differences in COVID-ARDS outcomes, with higher ICU mortality in Argentina and Brazil than in the Netherlands and Spain, unlikely due to case mix or ventilation strategies. SATI–COVID–19, EPICCoV, PRoVENT–COVID, CIBERESUCICOVID and the PROVE Network (https://lnkd.in/dWinRK4z) in AJTMH: https://lnkd.in/dyEm-Jy8. #AmsterdamUMC #PROVENetwork #IntensiveCare #ICU #COVID #COVIDARDS #MechanicalVentilation #VentilationManagement #outcomes

‘PRIME’ — a Pooled Database for Comparing Ventilation in Neurocritical and Non-neurocritical Care PRIME integrates harmonized data from 3 large observational studies, PRoVENT (https://lnkd.in/d6a7KK58), PRoVENT—iMiC (https://lnkd.in/dsgxvdb2) and ENIO (https://lnkd.in/dsgxvdb2). PRIME is registered at clinicaltrials (https://lnkd.in/dXGEsBSP) and its protocol is now published: https://lnkd.in/dFVre3Qv. Ideally suited for analyzing ventilation management across patient groups, PRIME (https://lnkd.in/d-Qv_eME) is accessible via PROVE Network. For analysis inquiries, connect with simon corrado serafini or Chiara Robba. #PROVENetwork #PooledDatabases #ObservationalStudies #NeurocriticalCare

Exploring the Mechanical Power of Ventilation in Non-ARDS Patients Laura Buiteman-Kruizinga’s latest analysis of the wizARDS database (https://lnkd.in/dYy_mcRM) highlights airway pressures and respiratory rates as key drivers of MP. Lowering the respiratory rate could be a promising strategy to achieve lower MP. Further research is needed to validate these findings: … PERMISS! (https://lnkd.in/dgRYvz5u). Laura Buiteman-Kruizinga for the PROVE Network in Anesthesia: https://lnkd.in/dBfWgQvn #AmsterdamUMC #PROVENetwork #IntensiveCare #ICU #MechanicalVentilation #MechanicalPower #MP #TidalVolume #RespiratoryRate #DrivingPressure

Wishing You All a Wonderful New Year Filled with Health, Success, and Inspiration As we bid farewell to 2024, we reflect on a remarkable year for the PROVE Network. It has been a year of growth and achievement, marked by the launch of our new website, the addition of esteemed new steering committee members, the successful completion of impactful studies, and numerous thought-provoking publications that have advanced the field. To all those who share a passion for ventilation and the care of critically ill patients, thank you for your unwavering dedication and collaboration. Let us look forward to 2025 with optimism and continued commitment to innovation and excellence. Marcus Schultz, Marcelo Gama de Abreu, Ary Serpa Neto MD MSc PhD FCICM, Sabrine Hemmes, Guido Mazzinari, Juliana Ferreira, Chiara Robba, Denise Battaglini, David van Meenen, Lorenzo Ball, Martin Scharffenberg, Jakob Wittenstein, Frederique Paulus, Laura Buiteman-Kruizinga, Patricia Rocco, Silvia De Rosa, Prashant Nasa, and Robert Huhle.

Automation in Ventilation: Fewer Adjustments, but More Alarms—At What Cost? Michela Botta et al. compared automated ventilation using INTELLiVENT-ASV with conventional pressure-controlled or pressure support ventilation in critically ill patients undergoing invasive ventilation. The study found no differences in the quality of oxygenation between the two modes. Automated ventilation required fewer manual interventions but led to more ventilator alarms. Further research is needed to assess the impact of automated ventilation on ICU nursing staff workload. Read the full report in J Clin Med here: https://lnkd.in/daYpgdsk. This work was part of INTELLiPOWER, a substudy of a randomized crossover clinical trial conducted by PROVE Network (https://lnkd.in/dWinRK4z). #AmsterdamUMC #ReinierDeGraaf #PROVENetwork #PROVE #INTELLiPOWER #ICU #InvasiveVentilation #Ventilation #Automation #ClosedLoop #Oxygenation #Alarms #Alarmmanagement #Workload

PROVE Network Wishes You Happy Days and All the Best for 2025 Marcus Schultz, Marcelo Gama de Abreu, Ary Serpa Neto MD MSc PhD FCICM, Sabrine Hemmes, Guido Mazzinari, Juliana Ferreira, Chiara Robba, Denise Battaglini, David van Meenen, Lorenzo Ball, Martin Scharffenberg, Jakob Wittenstein, Frederique Paulus, Laura Buiteman-Kruizinga, Patricia Rocco, Silvia De Rosa, Prashant Nasa, and Robert Huhle.

Unlocking Insights with Win Ratio Analysis — re-evaluating PEEP in perioperative care The win ratio analysis is a novel statistical method that prioritizes clinically meaningful outcomes by comparing pairs of patients across a hierarchical composite measure. Ary Serpa Neto MD MSc PhD FCICM re-analysed the REPEAT database (https://lnkd.in/dub-7sqK, https://lnkd.in/dZeDtJtB, https://lnkd.in/dnDDU7Ua) using this method to evaluate the impact of high versus low PEEP during general anaesthesia for surgery, focusing on hospital mortality, hospital length of stay, and postoperative pulmonary complications, revealing no clear advantage of high PEEP: https://lnkd.in/dn-MGewJ. Excellent work by Ary Serpa Neto MD MSc PhD FCICM for the REPEAT—investigators of the PROVE Network. #AmsterdamUMC #PROtectiveVEntilationNetwork #PROVENetwork #REPEAT #Anesthesiology #IntraoperativeVentilation #Ventilation #PEEP #PPC #WinRatioAnalysis #WinRatio #WR