Prasad Lab I WSU

We are thrilled to congratulate Aarzoo Thakur (Dr Thakur) on the successful defense of her PhD work, focusing on the discovery and clinical translation of renal Organic Anion Transporter (OAT1/3) biomarkers. Aarzoo’s work is crucial for predicting renal drug-drug interactions and interindividual variability in OAT substrates, a significant step forward in precision medicine and clinical treatments. Aarzoo’s dedication, focus, and deep sense of ownership have been truly inspiring. Her research is a perfect example of how academic work can drive real-world, clinical impact and transform scientific discoveries into practical applications. As a team, we couldn’t be more proud of her outstanding achievements. Aarzoo, we wish you the best as you embark on the next chapter of your career. The sky is the limit for you!

Congratulations, Dr. Dilip Kumar Singh for this well-deserved recognition! https://lnkd.in/gTxRBzHR

Sandhya Subash, research associate at Prasad Lab I WSU, will be giving a talk on “Uncertainties and Opportunities in Predicting Non-CYP Mediated Drug Metabolism” at the Applied Pharmaceutical Analysis (APA) 2024 Meeting in Cambridge, MA on 9th October 2024. In case you are at the meeting, please attend the talk!

We are thrilled to share that Prasad Lab I WSU members won awards at the Pacific Northwest Association of Toxicologists (PANWAT) 2024 Regional Conference held in Seattle, WA. · Anoud Ailabouni was awarded first place in Graduate Poster Presentation category for her work on "Interindividual Variability in the Disposition and Pharmacokinetics of Organic Cation Substrates in Humans: Asymmetric Effects on Systemic and Tissue Exposures." · Kari Gaither won first place in Postdoctoral Poster Presentation category for her work on "Proteomic Changes in Human Hepatocytes Treated with Alcohol and its Association with the Liver Tissue proteome from Donors with Alcohol Exposure." ? Many congratulations to the winners! ????

Traditionally, developmental changes in the expression of cytochrome P450 (CYP) enzymes have been reported using mRNA expression and activity data from liver microsomes, which are prone to high technical variability due to contamination with other organelles or the loss of proteins during early fractionation. To address this, we used viable pediatric and adult human hepatocytes for the first time to map ontogeny of major CYP isoforms, including orphan CYPs (such CYPs 20A1, 27A1, 51A1, 7B1, 8B1, and the CYP4 subfamily) through quantitative proteomics. This data provides valuable insights to improve pediatric drug metabolism and refine PBPK models, enabling safer dosing for children. Check out our article now available online: https://lnkd.in/gANfcUZX

We are delighted to share that Dilip Kumar Singh from Prasad Lab I WSU was awarded first place in the Best Poster Presentation, Post-doctoral category at the 26th North American ISSX and 39th JSSX Meeting held in Honolulu last week. Dilip’s exemplary work on examining the ontogeny and inter-individual variability in hydrolytic drug-metabolizing enzymes in human liver was well received at the meeting. We are thankful to the #PRINCE consortium members for providing the resources to carry out this research.?????? Many?congratulations, Dilip!

In case you are attending the 26th North American ISSX and 39th JSSX Meeting (September 15-18, 2024), please visit the Prasad Lab I WSU posters and attend our presentations. Looking forward to connecting with you during the meeting! Here's the agenda of the lab posters/presentations:

Prasad Lab is organizing?a series of educational sessions sponsored by Mass Spec vendors?titled “Unlocking the Omics Potential: An In-Depth Luncheon Lecture Series on Proteomics and Metabolomics,” featuring sessions from different mass spectrometry vendors. For the first?session, folks from Thermo Fisher Scientific will be presenting on “Advances in Mass Spectrometry Instrumentation” from 11 AM to 2 PM, PDT, on Wednesday, 11th September 2024. Interested individuals can register for the event and attend the session virtually. Students are highly encouraged to attend the session! For registration, click here:?https://lnkd.in/gz4WaWac Meeting agenda is available in the flyer.

Immature drug elimination pathways in children can lead to drug toxicity. While the ontogeny of various hepatic DMET proteins has been reported, the data are often from subcellular fractions isolated from frozen tissue and are prone to high technical variability. To address this, we characterized the ontogeny of 34 hepatic drug transporters and conjugating enzymes in 50 pediatric and 8 adult human hepatocyte samples. Incorporating this data in PBPK models can help improve pediatric dose prediction, leading to safer drug pharmacotherapy in children. The article can be accessed here: https://lnkd.in/g2BJpzR5 Thanks to all the co-authors (Sandhya Subash, Deepak Ahire, PhD, and Bhagwat Prasad) for their invaluable contributions to this work!

I recently had the pleasure of attending the Gordon Research Seminar and Conference 2024 on Drug Metabolism, where I connected with brilliant scientists, graduate students, and pharma industry professionals from around the globe. It was a one of its kind, incredible experience, full of inspiring conversations, innovative ideas, and cutting-edge research ?????? I also had the honor of presenting my scientific research as a poster titled "Evidence of the inhibition of OCT1-mediated hepatic uptake of metformin by piperine: A spice-drug interaction with potential implications to metformin efficacy", which sparked some fantastic discussions and valuable feedback. ?? A huge thank you to the GRS chairs?Deepak Ahire, PhD,?Annamarie Bustion, PhD and GRC chair?John Harrelson,?and vice-chair?Mitchell Taub for organizing this year's conference. I am grateful to my PI, Dr. Bhagwat Prasad, for his constant support and mentoring and for bestowing me the opportunity to present my research work on such a big platform. Also, thank you to everyone who stopped by to chat. I am looking forward to continuing these conversations and exploring new collaborations!?? #GRC2024 #ScientificResearch #PharmaIndustry #Networking #ProfessionalGrowth