Porton Advanced | ATMP CDMO/CRO

?? Safety and Transduction Efficiency of Lentivirus Helper Plasmids Q2: What advancements have been made in the design of lentivirus helper plasmids to enhance their efficiency and safety? Advances in lentivirus helper plasmid design have focused on increasing transduction efficiency and enhancing safety. Innovations include the incorporation of self-inactivating (SIN) vectors, which reduce promoter activity in the long terminal repeat (LTR) regions, and the use of pseudotyping with different envelope proteins (e.g., VSV-G) to broaden tropism and improve stability. Moreover, improvements in plasmid backbones and the use of codon optimization enhance the expression of viral proteins, resulting in higher titers of produced lentiviral vectors. Follow us to read the scientific series and stay tuned for the last question for lentivirus helper plasmids! ?? ?? Read more: https://lnkd.in/gTQjhSe5 ?? Explore how Porton Advanced can assist you with lentivirus helper plasmids: https://lnkd.in/gRfSrMHq ?? Contact us: https://lnkd.in/gge_QVR8 #ATMP #CDMO #PortonAdvanced #LentiviralVectors #Plasmid #LentivirusHelperPlasmids #Lentivirus

???? Today is Rare Disease Day – A Day to Shine a Light on Hope! ???? At Porton Advanced (https://lnkd.in/gtvGNKHj), we stand with the 300 million people worldwide affected by rare diseases. Cell and gene therapies are transforming treatment possibilities, offering hope where none existed before. ?? Advancing Cell Therapy & Investigator-Initiated Trial (IIT) for Rare Diseases From CAR-T, TCR-T, and gene-edited T cells to MSC, NK, and iPSC-based therapies, we accelerate next-gen treatments with our CDMO and IIT services. ?? Investigator-initiated Trial (IIT) Services (https://lnkd.in/g8h32UiH): Enabling First-in-Human Studies ? End-to-end CMC & GMP manufacturing ? Regulatory & IND support ? Seamless transition from IIT to commercial production ? Clinical trial partnerships for rare disease therapies With our full-service IIT platform, we help innovators bring therapies from bench to bedside—faster. ?? On this Rare Disease Day, we remain committed to advancing life-changing therapies! #RareDiseaseDay #CellTherapy #GeneTherapy #IIT #PortonAdvanced #HopeForRareDiseases

?? Safety and Transduction Efficiency of Lentivirus Helper Plasmids ? Q1: What are the safety considerations when using lentivirus helper plasmids in research and clinical settings? Safety is paramount when using lentivirus helper plasmids. Researchers employ several strategies to minimize risks, including the use of third-generation packaging systems, which separate the viral functions into multiple plasmids, thus reducing the likelihood of recombination and generation of replication-competent viruses. Additionally, laboratory practices such as working in biosafety level 2 (BSL-2) facilities, using physical containment devices, and adhering to rigorous waste disposal protocols are implemented to ensure safe handling and reduce the risk of accidental exposure. You may ask what advancements have been made in the design of lentivirus helper plasmids to enhance their efficiency and safety? Follow us to read the scientific series and stay tuned for the following question for lentivirus helper plasmids! ?? ? ?? Read more: https://lnkd.in/gTQjhSe5 ?? Explore how Porton Advanced can assist you with lentivirus helper plasmids: https://lnkd.in/gRfSrMHq ??? Contact us: https://lnkd.in/gge_QVR8 #ATMP #CDMO #PortonAdvanced #LentiviralVectors #Plasmid #LentivirusHelperPlasmids #Lentivirus

?? Porton Advanced | ATMP CDMO/CRO is attending the Vendor Showcase at Valley Research Park in California on February 11! Please come visit our table between 12:00 PM and 1:30 PM for a chat! Date & Time: 2/11/2025 between 12:00 PM - 1:30 PM Table: Porton Advanced Venue: Valley Research Park, 319 Break Room Visit our table to learn more about our #ATMP #CDMO services and how we can support your research and development goals. Please come and enjoy complimentary lunch, refreshments, giveaways, and free tours of the biotech startup incubator space. We look forward to connecting with you at the event! If you would like to schedule a meeting with our experts or your local representatives, please email us at:?[email protected].

???? Celebrating Spring Festival 2025! ???? As we welcome the Year of the Snake, we extend our deepest gratitude to our colleagues, partners, and clients for their continued support and collaboration. Your dedication and hard work have been the foundation of our success, and together, we look forward to achieving even greater milestones in the coming year. May this Spring Festival bring you and your loved ones happiness, prosperity, and good health. Let's embrace the opportunities that 2025 has to offer and make it a year to remember! Wishing everyone a joyful and prosperous Year of the Snake! ???? #SpringFestival2025 #YearOfTheSnake #PortonAdvanced #CDMO?

?? Curious about conducting investigator-initiated clinical trials in China? Porton Advanced has recently achieved a major milestone by successfully completing the import of a batch of overseas biological products to China. We've established a reliable import and export process for a variety of biological samples, providing essential support for overseas #ATMP projects aiming to conduct investigator-initiated clinical trials in China. Our stringent, full-process management system ensures both the efficiency and safety of the import process. With experience in handling various biological samples—including AAV-293 cell lines, viral vectors, mycoplasma, nucleic acids, and more—Porton Advanced showcases its professional capabilities in seamless import and export processes. Read more about investigator-initiated clinical trials in China here: https://lnkd.in/eVDnyNVk Download Brochures here: https://lnkd.in/gBJPPutd Contact us here: https://lnkd.in/gge_QVR8 #PortonAdvanced #ClinicalTrials #Biotech #ImportExport #ATMP #GlobalCollaboration

?? Game-Changer for 2025! CAR T Therapies: Ushering in a New Era with Porton Advanced! ?? 2025 is kicking off with groundbreaking advancements in CAR T therapy, and Porton Advanced | ATMP CDMO/CRO is here to help you stay ahead of the curve! - Why Partner with Porton Advanced? 1. Expertise You Can Trust: With years of experience in cell therapy CMC manufacturing, we specialize in CAR-T, UCAR-T, γδ T, TCR-T, and more. 2. End-to-End Solutions: From vector cloning to clinical-grade manufacturing, we provide seamless support through every stage of your CAR T development. 3. Proven Track Record: We've successfully supported clients in obtaining 16 global IND approvals, including 4 FDA IND approvals. - Ready to take your CAR T therapy to the next level? Contact Shelley HL Wu today to explore how we can accelerate your project’s success! #CellTherapy #CART #Biotech #CDMO #Innovation #GeneTherapy #PortonAdvanced

???Porton Advanced | ATMP CDMO/CRO has received a heartfelt thank you letter from our client regarding Project C2436, recognizing our outstanding performance and professional services in project management and delivery. Leveraging our comprehensive nucleic acid CDMO platform, Porton Advanced successfully completed the entire workflow from plasmid to lipid nanoparticle (LNP) formulation pilot production in just two weeks, achieving a remarkable 100% release success rate. Our team delivered multiple batches of plasmids, in vitro transcription (IVT) mRNA, and LNP formulations. This achievement highlights our exceptional service quality and efficient management in project communication, tackling technical challenges, optimizing processes, and understanding client needs. These efforts have significantly accelerated the drug development and regulatory submission process. A big thank you to our dedicated team and valued clients for making this possible. We look forward to continuing to drive innovation and success together! Learn more about mRNA/LNP production service: https://lnkd.in/gYvdjE3T #Plasmid #mRNA #LNP #PortonAdvanced #CDMO

As the holiday season fills the air with warmth and joy, we at Porton Advanced | ATMP CDMO/CRO sincerely thank you for your trust and partnership. May your Christmas be merry and bright, and the New Year bring success, innovation, and new opportunities. Here's to advancing together in 2025 and beyond! ???

Join Porton Advanced | ATMP CDMO/CRO today at the SSE Biotech vendor show at the North Torrey Pines Science Park in La Jolla! Please come visit our table between 12PM and 1:30PM for a chat, and get our popular massage hammers! ?? Date: 12/10/24 ?? Time: 12:00 pm - 1:30 pm ?? Venue: North Torrey Pines Science Park – Sanford Burnham Prebys Medical Discovery Institute ?? Address: 11011 North Torrey Pines Road, La Jolla, CA 92037 Enjoy free lunch and drinks! We look forward to seeing you there. Don't miss out!