Publication Spotlight! 💡 What do you get when you utilize single-use #VerticalWheel bioreactors in the reproducible and scalable production of cerebellar organoids? Find out in our latest publication spotlight, 'Transcriptome profiling of human induced pluripotent stem cell-derived cerebellar organoids reveals faster commitment under dynamic conditions' 🔬 The full publication can be found here: https://hubs.li/Q02ZF3l30 #Organoids #hIPSCs #ScaleUp
关于我们
PBS Biotech aims to be the leading provider of innovative, single-use bioreactor systems specifically designed to address the unique challenges of cultivating shear sensitive cell types for cell therapy development. Our offering includes scalable, cost-effective disposable solutions designed to take you from benchtop R&D to large-scale cGMP manufacturing, and expert process development services to help solve cell culture challenges and accelerate your path to commercialization. To learn more, contact our sales team at sales@pbsbiotech.com or visit our website at www.pbsbiotech.com
- 网站
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http://www.pbsbiotech.com
PBS Biotech的外部链接
- 所属行业
- 生物技术研究
- 规模
- 51-200 人
- 总部
- Camarillo,California
- 类型
- 私人持股
- 创立
- 2008
- 领域
- Disposable bioreactors、Bioprocess solutions、Lab to cGMP cell culture development、USP Class VI plastics、cell therapy solutions、process development services、cGMP、iPSCs、MSCs、Pluripotent stem cells、Mesenchymal stem cells、stem cells、scale-up、3D cell culture、Single-use bioreactors、SUBs和process development
地点
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主要
4721 Calle Carga
US,California,Camarillo,93012
PBS Biotech员工
动态
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Now playing: Homogeneous mixing of induced pluripotent stem cells (iPSCs) in the PBS 3L Bioreactor! 🎥 This month we celebrated a remarkable milestone of 300 installations of our PBS 3L bioreactor. 🎉 We are deeply grateful for the unwavering support of our incredible customers, whose trust and loyalty made this achievement possible. Got questions? We are here to support you every step of the way on your linear scale-up journey! 📈 Contact us for more information here: https://hubs.li/Q02ZtV530 #ScienceForward #CellExpansion #VerticalWheel
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For biotech leaders and visionaries, the comprehensive roadmap offered by PBS Biotech #VerticalWheelBioreactor Platform in combination with RoosterBio Inc.’s hMSCs , expansion media, and bioreactor feed can guide clinical manufacturing with precision and efficacy from early phase clinical trials to full-scale commercialization. Check out the article below to join the conversation on the potential transformative impact powerful collaborations like this can have on #biotech advancements and patient care. 🚨 https://lnkd.in/e4mPiNig #cellandgenetherapy #regenerativemedicine #msc #biotechnolofy #advancedtherapies #celltherapymanufacturing
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Every journey has a beginning. If your vision is to one day scale to hundreds of billions of cells for your cell therapy, then that journey begins with the PBS Mini! https://lnkd.in/gs7DUMpJ
Imagine you just received your PBS Mini! 🎉 Check out the functions and features of the PBS Mini, plus a look at our Mini Vessels available in two sizes: 100 mL and 500 mL. To see what Vertical-Wheel technology can do for your cell therapy process, visit our website for more! 🎥 Watch full video here: https://hubs.ly/Q02XdSb_0 #VerticalWheel #Bioreactor #CellTherapy
Meet the PBS Mini: Vertical-Wheel Bioreactor
https://www.youtube.com/
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PBS Biotech转发了
Imagine you just received your PBS Mini! 🎉 Check out the functions and features of the PBS Mini, plus a look at our Mini Vessels available in two sizes: 100 mL and 500 mL. To see what Vertical-Wheel technology can do for your cell therapy process, visit our website for more! 🎥 Watch full video here: https://hubs.ly/Q02XdSb_0 #VerticalWheel #Bioreactor #CellTherapy
Meet the PBS Mini: Vertical-Wheel Bioreactor
https://www.youtube.com/
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Our recent Webinar highlights the keys to efficient Linear Scale-Up of Shear-Sensitive Cell Therapy Products, don't miss out on the insights given in this expert-led presentation! Topics covered: ✔️Demonstrating liner scale-up of PSC aggregate expansion from PBS 0.1L to PBS 80L scale to produce over 200 Billion PSCs from one bioreactor. ✔️Utilizing the wide operating window of the Vertical-Wheel Bioreactor family to enable effective scale-down model process development for linear scale-up. Rewatch the full Webinar here: https://hubs.ly/Q02Z0rND0 Visit our website for even more cell therapy resources! 📸: Incredible shot of mesenchymal stem cells (#MSCs) grown on Microcarriers harvested in the PBS Mini! #VerticalWheel #ScaleUp #CellTherapy
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Regular sampling allows you to make informed adjustments and ensures optimal conditions throughout your cell culture process. 🔎 Join our Sr. Applications Engineer, Kenny C. for an expert-led detailed look at sampling completed in the 0.5L PBS Mini. SPOILER ALERT: Hydrodynamics at play! 🌊 🎥Watch the Full video here: https://hubs.li/Q02YBFLH0 #CellCutlure #Hydrodynamics #VerticalWheel
Sampling in PBS Mini
https://www.youtube.com/
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💡 #Publication Spotlight! Seeking a breakthrough in iPSC expansion? We would like to spotlight this publication from the Stem Cell Research & Therapy journal- BMC. Transform your cell expansion protocol with revolutionary Vertical-Wheel technology in 3D cell culture! 🚀 Would like to learn more? Visit our website for the latest on our products and services. We look forward to connecting with you! 👉Read the full publication here: https://hubs.ly/Q02YrC-n0 #3D #CellExpansion #iPSC #VerticalWheelBioreactor
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Excellent publication by Trailhead Biosystems describing a refined method for manufacturing functional #iPSC-derived β-cells using PBS Biotech Vertical-Wheel Bioreactors. Unlike traditional 2D protocols, this method enables optimal suspension culture conditions and #scalability required to serve as a potential source of #insulin-producing cells for the advancement of cell-replacement therapies for patients suffering with Type 1 #Diabetes Mellitus. #celltherapy #scaleup #verticalwheel
Excited to share our latest work on scalable #manufacturing of #iPSC-derived #insulin producing #βcells for Type 1 diabetes (T1D) treatment🌟 Type 1 diabetes, an autoimmune disorder requiring lifelong insulin therapy, has highlighted the need for innovative alternatives. Our research explores how iPSCs can provide a scalable source of functional β-cells, and we’ve made incredible progress toward optimizing this process. 🔬 What We Did - Explored critical bioreactor scale-up parameters using an advanced High Dimensional Design of Experiments (HD-DoE) protocol. - Implemented a three-stage suspension manufacturing process in 0.5L vertical wheel bioreactors, transitioning from adherent to scalable suspension culture. - Optimized stage times and nutrient profiles to improve differentiation and maturation of iPSC-derived islet-like clusters. 📈 Key Findings - Extended differentiation times and controlled lactate accumulation enhanced β-cell-like marker expression and function. - Cryopreserved aggregates retained viability and insulin secretion capacity post-recovery, demonstrating potential for storage and future transplantation therapies. - Continuous bioreactor runs showed promising metabolic shifts and differentiation profiles compared to traditional media change methods. This work represents a significant step forward in making scalable, cost effective, functional insulin-producing cells a reality. 🌟 A huge thank you to the amazing team at Trailhead Biosystems for their innovation and dedication in driving meaningful advancements in diabetes research and cell therapy! Special thanks to all co-authors: Alexandra Wells, Michael Majcher, Dhruv Nakhwa, Ryan King, Faruk Senturk, Dr. Roshan Padmanabhan, Jan Jensen, and PI Michael Bukys.
Identifying and optimizing critical process parameters for large-scale manufacturing of iPSC derived insulin-producing β-cells - Stem Cell Research & Therapy
stemcellres.biomedcentral.com
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#PublicationSpotlight 💡 "Human pluripotent stem cells (PSCs) hold great promise for promoting regenerative medical therapies due to their ability to generate multiple mature cell types and for their high expansion potential." Topics covered in this publication include: ✔️ Effective 3D Differentiation ✔️ Consistency in Morphology and Cell Cycle profiles Read FULL publication here 👇: https://hubs.ly/Q02XPhfr0 #Microcarriers #iPSCs #3DSuspensionCulture