The Pancreatic Cancer Center of Los Angeles

The Pancreatic Cancer Center of Los Angeles is the medical destination for patients in need of highly effective and safe treatment for pancreatic cancer. Led by Dr. William Isacoff, our team of doctors use staging to assess the extent of the cancer and the prognosis of the patient. Dr. William H. Isacoff was born in Brooklyn, New York and raised on Long Island. He received his undergraduate degree from Hofstra University, and in 1970 his medical degree from New York Medical College. At the completion of his fellowship training in Hematology and Oncology, Dr. Isacoff accepted a teaching appointment at UCLA-Harbor General Hospital and served as the Associate Chief of Medical Oncology, which he held until 1980. He was a pioneer in the research of the biochemical-pharmacology of methotrexate which resulted in the safe use of high-dose formulations for patients with bone cancer (osteogenic sarcoma). This work led to its safe use in the adjuvant setting which enabled patients to be cured without the necessity of amputation. He advocated the routine monitoring of methotrexate plasma levels in patients with bone cancer who were receiving high-dose formulations of this drug. This was made possible because Dr. Isacoff helped develop the analytical technique for measuring methotrexate in the patient’s plasma. Prior to the availability of monitoring plasma levels of these patients, the drug-related mortality was approaching 20% nationally for patients being treated on NCI approved protocols. Dr. Isacoff was able to identify patients at high risk of developing serious toxicity, and thus intervened with a modified dose and schedule of an antidote (referred to as a rescue) to methotrexate. This reduced the national drug-related mortality to less than 1% and ultimately allowed its safe use in the adjuvant setting which enabled patients with bone cancer to be cured without the need of an amputation.

网站

https://pancreaticcancercenterla.com

The Pancreatic Cancer Center of Los Angeles的外部链接

所属行业

医疗机构

规模

2-10 人

总部

Santa Monica，California

类型

私人持股

领域

oncology、chemotherapy、cancer treatment和pancreatic cancer