In Kyoto? Say hello to our OpenEye scientist, Chiharu K., at the Japan Medicinal Chemistry Symposium 2024 for robust scientific discussions and presentations. #drugdiscovery #crypticpocket? https://lnkd.in/gmxPqJg5
关于我们
OpenEye, Cadence Molecular Sciences is an industry leader in computational molecular design based on decades of delivering rapid, robust, and scalable software, toolkits, and technology and design services across the drug discovery process. Our scientific approach has focused on visualizing and analyzing the shape and electrostatics of molecular 3D structures to inform and guide the advancement of pharmaceuticals and biotechnology. OpenEye recently integrated its applications and toolkits into Orion, the only cloud-native, fully integrated molecular design platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in an open development platform, Orion offers unprecedented capabilities for drug discovery and optimization. Founded in 1997, OpenEye was acquired by Cadence Design Systems (NASDAQ: CDNS) in August 2022. OpenEye is headquartered in Santa Fe, New Mexico, with offices in Boston, Massachusetts; Cologne, Germany; and Tokyo, Japan. For more information, go to https://www.openeye.inc.
- 网站
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https://www.openeye.inc
OpenEye, Cadence Molecular Sciences的外部链接
- 所属行业
- 软件开发
- 规模
- 51-200 人
- 总部
- Santa Fe，NM
- 类型
- 上市公司
- 创立
- 1997
- 领域
- molecular modeling、virtual screening、shape、electrostatics、cheminformatics、visualization、statistics、cloud computing、SaaS、HPC、AWS partner、computational chemistry、docking、protein-ligand interaction、CADD、drug discovery、large scale virtual screening和crystal structure prediction
地点
OpenEye, Cadence Molecular Sciences员工
动态
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Join us at our next webinar on November 21st, 2024 where we’ll explore the capabilities of Orion?, OpenEye’s cloud-native modeling platform. The webinar will include a high-level overview of Orion's functionality and insights into advanced methods like cryptic pocket detection and non-equilibrium switching for relative binding free energy calculations Don’t miss this chance to see how Orion is redefining the drug discovery process!
miniWEBINAR: Orion?: A Cloud-Native Molecular Modeling Platform
eyesopen.com
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OpenEye, Cadence Molecular Sciences转发了
We’re excited to share that Fortune and Great Place To Work US have named Cadence one of the World’s Best Workplaces, ranking #9 for 2024! ?? Huge thanks to our amazing global teams for making this happen! Together, we’re building an inspiring workplace where everyone thrives. Let’s keep the momentum going! ?? https://ow.ly/Og5C50U7zCj #WeAreCadence #WorldsBestWorkplaces
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Yesterday's miniCUP Boston event brought together scientists, industry leaders, and researchers to discuss the latest advancements in computational chemistry and molecular modeling. Attendees learned about the latest advances from OpenEye and networked with other scientists. Thank you to everyone who attended!
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Hot off the press! Cryptic pockets have the potential to open new therapeutic opportunities by revealing ligand binding sites that remain hidden in static apo structures of a target protein. To uncover these cryptic pockets, OpenEye’s scientists applied Weighted Ensemble path sampling to enhance protein motion along normal modes, and then used a combination of analysis methods—Exposon Analysis, Probe Map, and Dynamic Probe Binding—to successfully identify cryptic pockets on the G12D isoform of the KRAS oncoprotein. Now available as Articles ASAP on JCIM. Neha Vithani, She Zhang, Jeff Thompson, Lara Patel, Alexander Demidov, Junchao Xia, Alexander Balaeff, Ahmet Mentes, PhD, Yelena Arnautova, Anna Kohlmann, David Lawson, Anthony Nicholls, Geoff Skillman and David LeBard Cadence Design Systems
Exploration of Cryptic Pockets Using Enhanced Sampling Along Normal Modes: A Case Study of KRAS G12D
pubs.acs.org
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There is still time to register for miniCUP Boston this week!
This Thursday (Nov 7th) in Boston! ? Join us at the Museum of Science for OpenEye, Cadence Molecular Sciences industry event 'miniCUP'. Find the link below to see the full agenda (chock full of our latest scientific developments) and register at no cost. https://lnkd.in/eEDXcZuk
miniCUP Boston 2024
eyesopen.com
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Boost Your Career in Computational Drug Discovery!??? Learn core concepts in Lead Optimization. Looking to enhance your knowledge of key concepts in computational drug discovery? Want practical insights on finding and optimizing drug candidates? Join us for “Essentials of Computational Drug Discovery” - a new four-part lecture series presented by expert scientists at OpenEye —all at no cost to you! ?? Tues Nov 12, 2024 - Lecture 3: Essentials of Affinity Prediction in Lead Optimization Register now and secure your spot! Cadence Design Systems
Essentials of Computational Drug Discovery | Sep-Dec 2024
eyesopen.com
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In Tokyo? Join us at the Japan Chem-Bio Informatics Society 2024 conference for robust scientific discussions and poster sessions from October 29th-31st. #CBI2024
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