OARSI - Osteoarthritis Research Society International

?????????????????? ?????????????????????? ?????? ?????????? ?????????????? ???? ???????? ???????? ???????????????????? OARSI members are invited to apply for one of the invited slots with waived ticket fees for Advanced Therapies in Orthopaedics Foundation (ATiO) Conference, taking place June 25–27, 2025, in Berlin, Germany. These spots are reserved for researchers and clinicians in orthopaedics and musculoskeletal therapies, providing them with the opportunity to engage with key industry leaders, investors, and decision-makers at this exclusive, invitation-only event. OARSI members interested in applying must submit: 1) CV, including five most important publications 2) short statement (max. 300 words) outlining your motivation to attend the conference 3) If applicable, details of involvement in a spin-off or startup related to musculoskeletal therapies The application deadline is April 30, 2025 and selected participants will be notified by May 4, 2025. Applications can now be submitted via the following link: https://lnkd.in/dxyyTwEq

?? ???????? ???? ?????? ?????? ???????????????? ???????????????? ???? ???????????? 27 ?????????? ???? ?????? ?????????? ?????????? ???????????????? ???? ????????????????????????????! ?? We’re excited to announce the following sessions on Sunday 27 April at the upcoming OARSI World Congress on Osteoarthritis! ???????????????????? ?????????????? ????: ???????????????? ?????????????????????????? ?????? ???????????????????? ???? ???? ???????????????? (8:45 AM to 10:15 AM) ?? Multi-Omic Strategies and Machine Learning: Application of integrative multi-omic approaches combined with machine learning to enhance OA research. ?? Genomics, Epigenetics & OA Risk: Presentations on spatiotemporal methylation patterns in hip OA, GWAS findings on post-traumatic knee OA, and genetic influences on hip shape and OA progression. ?? Microbiome & Inflammatory Regulation: The role of gut microbiota in modulating low-dose LPS signaling, neutrophil-driven osteogenesis, and maintaining inflammatory homeostasis in OA. ???????????????????? ?????????????? ????: ???????????? ?????? ??????????: ???????????????? ??????????????, ????-?????????????????????? ?????? ?????????? ???????????? (8:45 AM to 10:15 AM) ?? Sex/Gender Differences in OA: Exploring how biological sex and gender influence OA development and progression. ?? Metabolic and Systemic Factors: Presentations on how metabolic conditions like obesity, sarcopenia, and metabolic syndrome contribute to OA development, and how weight loss and aerobic exercise influence joint health. ?? Co-Morbidities and Systemic Inflammation: Presentations on the relationship between OA and systemic diseases such as cardiovascular conditions, diabetes, and the effects of adiposity on OA pathophysiology. Biomarkers and OA Progression: The role of biomarkers like MMP-3 and the impact of fat mass on disease severity and progression in OA patients. ?????????????? ?????????????? ??: ???????? ???? ???????????? (10:30 AM?-?12:15 PM) ?? Biology ?? Biomarkers ?? Biomechanics and Gait ?? Genetics, Genomics, and Epigenetics ?? Imaging ?? OA Clinical: Epidemiology and Therapy ?? Rehabilitation and Outcomes Visit https://congress.oarsi.org for details and registration. #OARSI2025 #OsteoarthritisResearch?

?? ???????? ???? ?????? ?????? ???????????????? ???????????????????? ???????????????? ???? ???????????????? 26 ?????????? ???? ?????? ?????????? ?????????? ???????????????? ???? ????????????????????????????! ?? Clinical Aspects and Outcomes in OA (8:45 AM to 10:15 AM) ?? Intervention Effects: Insights into the efficacy of various treatments for osteoarthritis. ?? Emerging Research Findings: Presentations on digital health literacy, the impact of viral infections on knee and hip OA, and the relationship between walking and the onset of knee OA. ?? Risk Factors and Progression: Presentations on factors influencing OA, including waist circumference, air pollution exposure, and the effects of resistance training on knee joint health in postmenopausal women. New and Innovative Treatments (8:45 AM to 10:15 AM) ?? Regenerative Medicine Approaches: Exploring the role of neural crest-derived cells in limb regeneration. ?? Nanotechnology-Based Therapies: Presentations on apoptotic body-inspired nanotherapeutics targeting synovial macrophages, collagen-targeting nanomicelles for enhanced cartilage treatment, and magnetic nanoemulsions as intra-articular therapeutic strategies. ?? Molecular and Cellular Targets: Presentations on novel targets such as NLRP3/NLRP1 inflammasomes, interleukin 11 for arthrofibrosis therapy, and adenosine and guanosine-based oligonucleotides to attenuate catabolic phenotypes in chondrocytes. Beyond Hip & Knee OA (2:00 PM - 3:30 PM) ?? Mechanosensing and Plasticity of Tendons and Ligaments: The role of tendons and ligaments in responding to mechanical stimuli, crucial for understanding OA beyond the hip and knee joints. ?? OA in Other Joints: Presentations on osteoarthritis in the shoulder, fingers, ankle, and temporomandibular joints, including bone texture changes and surgical outcomes. ?? Pain Management & Interventions: Presentations on the impact of antidepressants on OA pain, biomechanical approaches to low back pain, and novel therapeutic strategies. Molecular Drivers of OA (2:00 PM - 3:30 PM) ?? Neurochemical Changes and Cognitive Effects: Exploring the connections between osteoarthritis, pain, anxiety, memory deficits, and associated neurochemical alterations. ?? Genetic and Molecular Mechanisms: Presentations on key molecular factors influencing osteoarthritis, including PRDM16's role in cartilage homeostasis, transcriptome regulation identifying effector genes, and the impact of YAP1-regulated glycolysis in synoviocytes on disease progression. ?? Inflammation and Cellular Pathways: Presentations on the roles of acetylcholinesterase in cartilage maintenance, mitochondrial dysfunction linked to interferon signaling, angiogenesis in synovial tissues, and the influence of senescent immune cells via the GCA-PLXINB2 axis. Visit https://congress.oarsi.org for details and registration. #OARSI2025 #OsteoarthritisResearch?

?????????????????? ???????????????????????? ?????? ???? ?????? ?????????????? ???? ?????? ?????????? 2025 ?????????? ???????????????? ???? ????????????????????????????!?? Here's a snapshot of the concurrent sessions scheduled for Friday, April 25th: ??:???? ???? - ????:???? ????: ???????????????????? ????????????????: ?? Joint Related Tissue: Focusing on synovitis in knee osteoarthritis. ?? Risk Factors, Prevention, and Early Disease: Discussing the components of early osteoarthritis and preventive strategies. ??:???? ???? - ??:???? ????: ???????????????????? ????????????????: ?? Molecular Circuits Regulating Joint Destruction: Examining the influence of circadian rhythms and mechanical loading on joint health. ?? Rehabilitation Medicine and Biomechanics: Exploring the future of exercise therapy for knee and hip osteoarthritis. ??:???? ???? - ??:???? ????: ???????????? ?????????????? ?? ?? An opportunity to engage with the latest research findings. ??:???? ???? - ??:???? ????: ???????????????????? ????????????????: ?? Imaging: Investigating the relationship between pain and imaging techniques. ?? Pain: From Basic to Clinic: Advancements in sodium channel-mediated regulation of osteoarthritis pain. Join us for a day filled with insightful discussions and groundbreaking research in osteoarthritis. Don't miss the chance to connect with experts and peers in the field. Visit https://congress.oarsi.org for details and registration. #OARSI2025 #OsteoarthritisResearch?

?? Start your OARSI World Congress day with expert-led learning! ????? Join us for ?????????????????? ?????????????????? at the ?????????? ?????????? ???????????????? —an opportunity to dive deep into cutting-edge topics with leading experts. These workshops require pre-registration and an additional fee, so be sure to sign up during conference registration! ?????????? ???????? ???????????????????????? ???????? ???? ?????????? 7????! ????????????, ?????????? ???? ?????????????????? ???????????????? ??: ?????????? ???????????????????? ???? ?????? ???????????????????? ???????????????????? ???? ???????? ????????????????????????????: ?????????? ???? ?????? ?????? (??????????-?????????? ?????????? ??????????????????) Ali Mobasheri & Roland Chapurlat ??The Delineation of Endotype and Phenotype to Identify the Patients with Knee Osteoarthritis Who Should Be Treated ??The Role of Biomarkers (Imaging, Biological) to Identify the Patients with Knee Osteoarthritis Who Should Be Treated ?????????????????? ???????????????? ??: ?????????????????????? ????????????, ???????????????????????????? ?????? ???????? Andras Bilkei-Gorzo, Katarzyna Starowicz, Rafael Maldonado ??Cannabinoid System in Brain-Periphery Interactions ??Exploring Cannabinoid-Based Therapeutics for Osteoarthritis: Mechanisms and Efficacy ??Involvement of CB2 Receptors in Chronic Pain ????????????????, ?????????? ???? ?????????????????? ???????????????? ??: ?????? ???????? ???? ???????????? ???? ???? Britt Elin ?iestad ??Clinical Associations Between Muscle Strength and OA of the Knee ??Skeletal Muscle Weakness in OA Progression ?????????????????? ???????????????? ??: ?????????? ?????????? ???????????????????????? ???? ?????????????? ???????????????????????? ???????????????? ?????? ????????????????????????????: ?????????????????? ???????? ???????????? ?????? ?????????? ?????????????? ???????????????? Nataly Kravchenko-Balasha & Jason Rockel ??Modeling Heterogeneity Towards Tailored Medicine: Examples From Cancer ??Omic Approaches to Better Understand Osteoarthritis ????????????, ?????????? ???? ?????????????????? ???????????????? ??: ???????????????????? ???? ?????????????? ???????? ?????? ?????????????????? ???? ???????????????????????????? Kent C. Kwoh & Ali Guermazi ??Mechanisms and Assessment of Pain in Osteoarthritis ??Structural Correlation of Pain: What Do We Know? ?????????????????? ???????????????? ??: ???????????????????? ???????????????????? ?????? ?????????????????????????? ???? ?????????? ???????????????????????????? ?????????????? ?????????????? Stefan Nehrer, Danny Chan, Marcel Karperien, Ali Mobasheri ??Artificial-Intelligence-Aided Diagnostic of Osteoarthritis ??Cells and Molecular Regulations in Joint Formation and OA ??Joint-on-Chip Platforms: a New Era of Models for Osteoarthritis ??Molecular Endotypes of Osteoarthritis and Implications for Therapeutic Development https://lnkd.in/eEvftpWY #OARSI2025 #Osteoarthritis #workshop

?????????????? ????????????????????????! The OARSI Asian Alliances Committee is hosting a webinar on?Thursday, March 6 at 7:30-8:30 am ET. Title: ?????????????????? ???????????????????? ???? ???????????????????????????? Session Description: Biomarkers have great promise for improving treatment outcomes. There is potential for biomarkers to support early diagnosis and intervention for osteoarthritis, as well as potentially distinguish between disease endotypes.?Despite substantial progress, there remain no molecular biomarkers in widespread use for osteoarthritis. This presentation will review recent progress in osteoarthritis biomarkers and discuss the potential of metabolomic profiling for developing osteoarthritis biomarkers. Presenter: Dr. Ronald June, Ph.D. Montana State University Department of Mechanical & Industrial Engineering Department of Microbiology & Cell Biology (Affiliate Faculty) More information in the attached flyer. Register here: https://lnkd.in/eX75xbXp

?? ???????????? ?????????? ???? ?????????? ????????!? ?? Osteoarthritis (OA) treatment is evolving—are we moving toward regenerative medicine, or will pharmacological approaches remain the gold standard? ?? Join us for a dynamic debate at OARSI 2025 in Incheon, South Korea! ?? Plenary Session 6: Debate ?? Saturday, April 26, 2025 ? 5:00 PM – 6:00 PM ?? ???????????? ?????????????????????? ?????? ??????????: ?????????????????? ????????-?????????? ?????????????????? ?????? ???????????????????????????? ?? Jérome Guicheux will champion cell-based regenerative therapies as a path forward for OA treatment. ?? ????????????????????-?????????? ?????????? ?? Philip Conaghan will argue the case for pharmacological interventions, the current mainstay of OA management. This session promises to be an insightful, evidence-based discussion on the future of OA therapy. Whether you’re a clinician, researcher, or industry expert, you won’t want to miss this! ?? ???????????????? ?????????? ?????? ???? ???????? ???? ?????? ????????????????????????!? https://lnkd.in/gyqNm8aH #OARSI2025 #Osteoarthritis #RegenerativeMedicine #Pharmacology #Debate #FutureOfMedicine

Day 1 of the ?????????? ?????????? ???????????????? #OARSI2025 features two exciting plenary sessions: ?????????????? ?????????????? ??????????????: ?????? ?????????? ???????? ????????????: ???????????????? ???????????????????? ?????????????? ???? 2:00 PM to 3:30 PM KST https://lnkd.in/eKGtNxsF ?????? ?????????????? ???????? ???????????????????? ?????? ???????????????????? ?????????????? ?????????????? ???????? ???? ???? Lars Arendt-Nielsen ?????? ???????????? ???? ?????????????????????????????? ???? ?????? ?????? ???????????? Jan Tuckermann ?????????????? ??????????????: ?????????????????????? ???? ?????????? ?????????????????????? ?????? ???????? ?????????? 6:30 PM to 7:30 PM KST https://lnkd.in/eXwwycVB ?????????????????????? ???? ????????-??????????, ???? ??????????-????-??-????????, ???? ?????????? ???????????????????????????? ???????????????????????? ?????? ???????? ?????????????????? Rocky Tuan ?????????????????????????? ???????????? ???? ???????? ?????????? ?????? ???????????????????????? ???????????????? Susan Kimber Find more information on the 2025 OARSI World Congress, including registration information, important dates, and the congress program here: https://lnkd.in/gyqNm8aH #OARSI2025 #OsteoarthritisResearch #Pain #RegenerativeMedicine #Biomimetics

?? OARSI is delighted to be hosting the OARSI World Congress in Asia! ?? OARSI is excited to welcome attendees to ??????????????, ?????????? ??????????’?? ?????????????? ???????? ???????? and a dynamic gateway to the heart of East Asia! Known for its modernity, rich history, and picturesque landscapes, Incheon offers a unique blend of experiences that will captivate travelers from around the globe. From the bustling streets of ???????????? ?????????????????????????? ???????????????? ????????????????, a futuristic hub of innovation, to the serene beauty of ??????????????’?? ?????????????? ??????????????, the city seamlessly merges tradition with cutting-edge development. Visitors can explore the charm of ??????????????????, home to Korea’s oldest Chinese community, savor authentic Korean cuisine, or take a stroll through the historic ???????? ???????? ????????, which reflects the city’s rich maritime heritage. Find more information here: https://lnkd.in/eyefjuNt including - information on the congress venue, Songdo Convensia - helpful travel tips - important information on getting a visa Please also see the attached brochure from our #OARSI local champions. #OARSI2025 #OsteoarthritisResearch #Incheon #SouthKorea

?? ???????? ???? ?????? ??????????????-???????? ??????-???????????????????? ?????????????????? ???? ?????? ?????????? ?????????? ???????????????? ???? ????????????????????????????!??? We’re excited to announce three pre-congress workshops at the upcoming ?????????? ?????????? ???????????????? ???? ????????????????????????????. Don't miss this chance to expand your knowledge and network! ??????-???????????????? ?????????????????? will take place on Thursday, April 24, 2025 8:00 AM - 10:30 AM. ???????????????????? ?????? ?????????????????????? ???? ????: ???????? ?????????? ?????????????? ???? ??????-???????????????? ?????????????? Explore how sex differences influence osteoarthritis development and treatment, including: ??The role of joint anatomy and sex hormones in OA progression. ??Advances in cartilage repair and tissue engineering. ??Insights into sex-specific genomics, epigenomics, and chondrocyte mechanobiology. ???? ???????????????????? ?????? ???????????????????????? ???? ???????? Discover strategies to improve OA care in Asia and beyond, including: ??Addressing misconceptions and enhancing education for self-management. ??Best practices in physical activity, diet, and weight management. ??The latest in pharmacotherapies, injectables, and dietary supplements. ?????? ?????? ???? ???????????????????? ???????????????????????? ???? ????: ???????????????? ?? ?????????????? ?????????????? Dive into the transformative potential of AI in osteoarthritis research: ??Highlights from the OAC special issue on AI applications in imaging. ??How AI is reshaping OA research, biomechanics, and publishing. ??The future of large language models in clinical and research applications. Visit https://congress.oarsi.org for details and registration. Note: Pre-Congress Workshop registration is required #OARSI2025 #OsteoarthritisResearch #AIinHealthcare #SexDifferences #Epidemiology #Workshops