O2M Technologies

For the first time, we show the power of deep learning in oxygen imaging. Thanks to National Cancer Institute (NCI) for funding the project. In collaboration with Alan McMillan from University of Wisconsin-Madison and Boris Epel from University of Chicago Great job team- Irene Canavesi Navin Viswakarma Mrignayani Kotecha, PhD University of Wisconsin Department of Medicine Check out the full paper (Accelerated EPR Imaging Using Deep Learning Denoising, Magnetic Resonance in Medicine, 2025): https://lnkd.in/g5PAujhm

New paper using a UNet and joint bilateral filters to accelerate and improve oxygen imaging with electron MRI:

Published in Issue! Access the full article from here: https://lnkd.in/dbahDvX4

JIVA-25? for Cancer Hypoxia Imaging, check out this recently published article from the group of Martyna Elas from Jagiellonian University detailing the protocol. National Cancer Institute (NCI) https://lnkd.in/gCdHZwXd

Second workshop at Cornell University! Cornell University

Upcoming workshop at Cornell University! Cornell University

We are bringing back the popular O2M webinar series. The topic of our next webinar is: "Application of Tissue Oxygenation Measurements in Mouse Models of Anemia to Inform Transfusion Quality", by Dr. Paul Buehler on March 20th, 2025, 3 pm ET. The webinar will be moderated by Dr. Christopher Kroenke. Hope you can join us. Register here: https://lnkd.in/gXrDjQKQ Abstract:?The goal of red blood cell transfusion is to transport and deliver O2?to tissues, yet astonishingly, tissue oxygenation is not measured to assess the effect of transfusion in clinical settings. Tissue perfusion and oxygenation define the effectiveness of red blood cell transfusions in life threatening anemia, which is determined by O2?availability and blood flow. Shear-dependent blood flow governs effective O2?transport to tissues and is affected by plasma volume and viscosity, and by red blood cell morphology, membrane mechanics, and orientation in blood vessels. Red blood cells are transfused after refrigerator storage (i.e., Blood Banking), which is allowable for up to forty-two days in most preservation solutions. Anemia may require multiple red blood cell transfusions, of varying storage duration and quality. The variability is linked to donor genetics (e.g., G6PD deficiency and STEAP3 polymorphisms) and the exposome (e.g., diet, drugs, exercise) which degrade red blood cell integrity at differing rates over time in refrigerator storage. Cellular energetics, O2?carrying capability and membrane function underpin the quality of red blood cells at the time of transfusion. Simultaneously studying RBC storage age, donor effects on RBC quality, recipient effects on blood flow and velocity, and ultimately tissue oxygenation, requires a reductionist approach to inform translation to human transfusion practices.??This talk will discuss the methods and approaches to understanding red blood cell quality in murine models of anemia with a focus on measurements of tissue oxygenation.

We are bringing back the popular O2M webinar series. The topic of our next webinar is: "Application of Tissue Oxygenation Measurements in Mouse Models of Anemia to Inform Transfusion Quality", by Dr. Paul Buehler on March 20th, 2025, 3 pm ET. The webinar will be moderated by Dr. Christopher Kroenke. Hope you can join us. Register here: https://lnkd.in/gXrDjQKQ Abstract:?The goal of red blood cell transfusion is to transport and deliver O2?to tissues, yet astonishingly, tissue oxygenation is not measured to assess the effect of transfusion in clinical settings. Tissue perfusion and oxygenation define the effectiveness of red blood cell transfusions in life threatening anemia, which is determined by O2?availability and blood flow. Shear-dependent blood flow governs effective O2?transport to tissues and is affected by plasma volume and viscosity, and by red blood cell morphology, membrane mechanics, and orientation in blood vessels. Red blood cells are transfused after refrigerator storage (i.e., Blood Banking), which is allowable for up to forty-two days in most preservation solutions. Anemia may require multiple red blood cell transfusions, of varying storage duration and quality. The variability is linked to donor genetics (e.g., G6PD deficiency and STEAP3 polymorphisms) and the exposome (e.g., diet, drugs, exercise) which degrade red blood cell integrity at differing rates over time in refrigerator storage. Cellular energetics, O2?carrying capability and membrane function underpin the quality of red blood cells at the time of transfusion. Simultaneously studying RBC storage age, donor effects on RBC quality, recipient effects on blood flow and velocity, and ultimately tissue oxygenation, requires a reductionist approach to inform translation to human transfusion practices.??This talk will discuss the methods and approaches to understanding red blood cell quality in murine models of anemia with a focus on measurements of tissue oxygenation.

We are bringing back the popular O2M webinar series. The topic of our next webinar is: "Application of Tissue Oxygenation Measurements in Mouse Models of Anemia to Inform Transfusion Quality", by Dr. Paul Buehler on March 20th, 2025, 3 pm ET. The webinar will be moderated by Dr. Christopher Kroenke. Hope you can join us. Register here: https://lnkd.in/gXrDjQKQ Abstract:?The goal of red blood cell transfusion is to transport and deliver O2?to tissues, yet astonishingly, tissue oxygenation is not measured to assess the effect of transfusion in clinical settings. Tissue perfusion and oxygenation define the effectiveness of red blood cell transfusions in life threatening anemia, which is determined by O2?availability and blood flow. Shear-dependent blood flow governs effective O2?transport to tissues and is affected by plasma volume and viscosity, and by red blood cell morphology, membrane mechanics, and orientation in blood vessels. Red blood cells are transfused after refrigerator storage (i.e., Blood Banking), which is allowable for up to forty-two days in most preservation solutions. Anemia may require multiple red blood cell transfusions, of varying storage duration and quality. The variability is linked to donor genetics (e.g., G6PD deficiency and STEAP3 polymorphisms) and the exposome (e.g., diet, drugs, exercise) which degrade red blood cell integrity at differing rates over time in refrigerator storage. Cellular energetics, O2?carrying capability and membrane function underpin the quality of red blood cells at the time of transfusion. Simultaneously studying RBC storage age, donor effects on RBC quality, recipient effects on blood flow and velocity, and ultimately tissue oxygenation, requires a reductionist approach to inform translation to human transfusion practices.??This talk will discuss the methods and approaches to understanding red blood cell quality in murine models of anemia with a focus on measurements of tissue oxygenation.

We enjoyed hosting Alan McMillan and his group from University of Wisconsin-Madison at our facility in O2M Technologies.