Nucleate Boston

This Thanksgiving, we extend our heartfelt gratitude to the incredible leaders and volunteers across all our global regions who make Nucleate’s mission possible. To our sponsors and partners—your support is the foundation of our impact, and we are endlessly thankful for your belief in what we do. To the mentors and experts who guide the next generation of biotech leaders with their time, knowledge, and passion—you are the backbone of our community and an invaluable force for innovation. A special shoutout to our amazing Activator teams—you are the driving force behind the success of our programs, bringing unparalleled energy, dedication, and creativity to everything you do. We truly couldn’t achieve this without you! Together, we are building a brighter future for science and entrepreneurship. Thank you all for making this journey extraordinary. Wishing everyone a Happy Thanksgiving! ??????

As we enter Thanksgiving week, we’re reflecting on how much we have to be grateful for here at Nucleate. In August, we shared our 5-Year Impact Report, celebrating the incredible journey of our community—from a small student-led program to a global nonprofit with 41 chapters, 15 programs, and over 255 teams empowered worldwide. None of this would have been possible without the unwavering support of our partners, mentors, advisors, volunteers, and sponsors. This week, we want to say THANK YOU: ?? To our partners and sponsors for believing in our mission and fueling our growth. ?? To our volunteer leaders for their dedication and vision. ?? To our mentors and advisors for guiding and empowering the next generation of biotech leaders. ?? To our global community for inspiring us to push boundaries every day. If you haven’t had a chance to dive into our journey, we invite you to revisit the 2019–2023 Impact Report and celebrate the impact we’ve made together. Your support is what makes this all possible. Here's to a future filled with continued collaboration and innovation. #Gratitude #Mentorship #Biotech

?? Calling all women in biotech ?? Nucleate Boston is thrilled to be hosting another installation of the Women in Biotech Dinner series where they will have a women-focused, close conversation that strives towards advancing science innovation, featuring several women leaders in the biotech space: Sofia Guerra, MBA – Vice President, Bessemer Venture Partners and Co-founder of Nucleate Kerry Love ??, PhD – Founder & CEO, Sunflower Therapeutics This is part of Nucleate's new global initiative to support women in leadership positions. The initiative aims to bring together women trainees in leadership positions with current women leaders in the life sciences. Each dinner is at a local restaurant in the host’s region and is sponsored by one of our national sponsors, Lyda Hill Philanthropies. At each dinner, 10 trainees and 2 invited executives/founders will be in attendance. While the initiative is global, these dinners aim to bring together local communities of women making an impact in the life sciences like you! The event will take place Tuesday, December 3rd from 5:00 PM to 7:00 PM EST Seats are limited – First come first serve! RSVP for more details at: https://lnkd.in/eXTCHU9R

At Nucleate, we believe that progress in science and innovation is driven by the strength of community, mentorship, and leadership. It’s not just about participation; it’s about empowerment—ensuring that leaders aren’t just present but are shaping the systems and opportunities for those who follow. In this post, we’re thrilled to spotlight four extraordinary women whose leadership and vision are integral to our mission and global growth. Isabella Cardona Barber, as EVP of Partnerships, fosters impactful collaborations that open doors and build bridges across the ecosystem. Her work ensures that opportunities are accessible and transformative. Jennifer Kosmatka, our EVP of Organizational Development, strengthens the foundation of our organization, cultivating a culture of resilience, adaptability, and inclusion. Andrea Boitnott, as EVP of Professional Advancement and Training Hub (PATH), leads efforts to equip future leaders with the tools and guidance they need to succeed, bridging the gap between potential and achievement. Inga Van den Bossche, EVP of Research, ensures our work is anchored in innovation and excellence, driving forward initiatives that pave the way for groundbreaking discoveries. These women are more than leaders—they are pioneers building a future where science and innovation are open, inclusive, and impactful. Their commitment to mentorship, collaboration, and accessibility exemplifies the values we strive to uphold every day. Whether you’re a leader ready to give back or someone seeking guidance to take the next step in your journey, we invite you to join us. Together, we can build a thriving community and shape the future of science and innovation.

Excited to share that Spateo, our framework for spatiotemporal modeling of single-cell holograms, is now online in Cell! Spateo's most notable advanced features are: ? Efficient 3D alignment and reconstruction that operate at whole-embryo scale, on the order of millions of cells (special thanks to Yifan Lu at the Qiu lab at Stanford!) ? 3D spatial domain definition and cell-cell communication tools to understand potential causes and consequences of spatial variability ? 3D morphometric analyses and 3D morphogenesis vector field modeling to predict cell migration ? A "Google Earth" analogue for 3D spatial data (https://lnkd.in/eBZStx_x) We applied our tools to a few of the intermediate stages in mouse embryogenesis, E9.5 and E11.5 (see the video!). At these stages, there is already remarkable cellular diversity, especially in the central nervous system, where 3D organizers are beginning to emerge and pattern the brain, and the heart, one of the first organs to form! We mapped part of the signaling landscape of the Zona Limitans Intrathalamica (ZLI), which acts to septate the diencephalon, and characterized left-right asymmetry in heart development.?Check out the full story (or at least the portion we could fit in print) and the companion piece in Nature News & Views below. https://lnkd.in/evk5T5a4 https://lnkd.in/eMvCqxux This work is an early step towards true predictive modeling of tissues and organs. As a molecular biologist at my core, I'm excited about a future where we can develop comprehensive virtual models that extend to the scale of embryos, and believe this work is an important step towards this future! Stay tuned for and (potential) future scientific updates, blog pieces and other fun things at my (under development) page (https://dzhu8.github.io). I'd like to thank the team for their collective efforts to make this possible, particularly Xiaojie Qiu, who is recruiting for his new lab at Stanford! #Science #Research #ScienceNews

Last night, Sanofi and Nucleate Boston co-hosted a panel on the topic Synergy in Innovation: Inspiring Stories of Startup-Pharma Partnerships. This is an area of particular interest for Nucleate with its alignment to our mission of empowering biotech leaders to transform their scientific discoveries into viable commercial ventures. Represented on the panel were voices from both the startup and pharma space: Cole Lewis of Cloverleaf Bio, Jen Rice, Ph.D. of Takeda, and Eric Kelsic of Dyno Therapeutics. All three of the panelists shared not only personal reflections on the nuances of startup-pharma relationships, but also actionable insights for attendees in their work on either side of these partnerships. Thank you again to Sanofi for enabling and sponsoring this illuminating event, and to Carla D'Avanzo, PhD for moderating the discussion!

Check out our latest episode of the Nucleate Podcast with Michael Langer, Co-founder & Managing Partner at T.Rx Capital & Executive Producer at MacGillivray Freeman Films. Join us as we explore: ??Michael’s career path at startups and as a VC. ??His unique experience as a filmmaker and the importance of storytelling. ??How exploring the world on service missions informed his career and life. ??Guidance for entrepreneurs interested in building strong teams. Catch the full episode and dive into these critical topics on Signal: https://lnkd.in/gGqxbJ4e More ways to listen: Apple: https://lnkd.in/gf8vyfEs Spotify: https://lnkd.in/gvTbwEvw YouTube: https://lnkd.in/g_HKdcuM

Curious about what it takes to bring a drug from preclinical development to patients? Join us for an insightful panel discussion featuring leaders from top biotech and pharmaceutical companies, sharing their unique paths towards spearheading clinical-stage drug development efforts. Featuring: Osaze Udeagbala, MD, MBA - Associate Medical Director, Takeda Jon Kluft, MD - VP, Business Development, Roivant Sciences Chris Wright, MD, PhD - Chief Medical Officer, Ring Therapeutics Date: December 4th, 5-6 pm ET RSVP here: https://lu.ma/cjigf2di Zoom information and a calendar invitation will be provided upon registration. Hope to see you there! This event is a prelude to our upcoming Clinical Development 101 series, a virtual course intended to provide participants with an understanding of the clinical development process and enable their pursuit of careers in this area. Stay tuned for more information! Nucleate organizers: Feyisayo Eweje, Robert F., Eshita G., Grace McAuley, Shahad Abdulsahib

?Nucleate Leadership Spotlight? Meet Suyen Espinoza Miranda, PhD , a Postdoc Scientist at the University of Würzburg, Germany, in the Vogel Lab. She is also the Co-Advisor of Global Activator Strategy for Nucleate HQ and was the founding Activator Lead of Nucleate Germany . Since her joining of Nucleate in 2023, Suyen has continued to make significant contributions to both her local chapter and Nucleate as a whole. As former Activator Lead and Co-Advisor of Global Activator Strategy, Suyen plays a pivotal role in fostering connections across our organization, strategically forging partnerships that bridge diverse fields. Her dedicated efforts not only enhance collaboration but also lay a robust foundation for the success of future Activator cycles, driving innovation and growth within our community. In her research, Suyen focuses on designing and optimizing single-cell RNA sequencing protocols in bacteria, aiming to refine and advance methodologies that enable groundbreaking scientific discoveries. Her overarching passion lies in making science accessible to all, fostering inclusivity and broadening the reach of scientific innovation. Suyen's dedication and perseverance have been pivotal in driving the global expansion of Nucleate, and we look forward to witnessing the lasting impact she will continue to make!

On November 18th, Foundess is partnering with Harvard Undergraduate Women in Entrepreneurship to bring you an inspiring evening filled with a fireside chat, networking, and demo night designed for female entrepreneurs! ???We would love to invite you to join us for this hybrid event, and connect with a vibrant community of women in the space! ?? What to Expect: ? Founder Matches: Before the event, you will be matched with another attendee to foster connections from the start. ? Demos: Pitch your idea in a safe space, and get feedback from industry veterans and fellow founders. This is the perfect place to find team members and practice your pitch! ? Fireside chat: Have an intimate conversation with a seasoned female entrepreneur (to be REVEALED). This event is open to ALL women passionate about entrepreneurship. You?don’t?need to have a fully-formed idea to attend—bring your curiosity and desire to connect. ?? For attendees in the Boston area, the in-person event will be at Harvard’s campus in Cambridge. We are also offering a virtual option, with the same offerings as the in-person event, to make this event accessible to fellow female entrepreneurs across the country! ??? ?? Date: November 18th, 2024, 5:45 PM - 8:30 PM EST ?? Location: Harvard University, Cambridge, MA (with a virtual option) ?? RSVP: https://lu.ma/hzzq8okd (In-person and virtual) ???????Hosted by:?Foundess, a nationwide community of early-stage female founders created by Stanford University, University of Michigan, and Tufts University students, in collaboration with Harvard Undergraduate Women in Entrepreneurship. Whether you’re here to launch, join, or simply learn, this evening promises meaningful connections and endless inspiration. Reserve your spot today (at https://lu.ma/hzzq8okd) and be part of an empowering community of women founders! ??