Fresh in Press: Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – systematic literature review. This article was built on the great master’s thesis work done by my supervisee, Tomasz Gogola.?The systematic review provided highly valuable background information also for my PhD research, which focuses on testing which environmental chemicals could influence MASLD progression. Thanks to all coauthors — happy to see this published! https://lnkd.in/g4x-KEuu Tomasz Gogola Marjo Huovinen Heikki Laitinen Jenni Küblbeck
NEMESIS Project
高等教育
Novel effect biomarkers for metabolic disruptors: evidence on health impacts to answer science and policy needs
关于我们
NEMESIS investigates how exposure to metabolism disrupting chemicals (MDCs) present in the environment, food, and consumer products alter our body’s normal metabolism processes and cause diseases, such as fatty liver and type 2 diabetes. The project brings together experts from multiple fields of research to answer persisting scientific uncertainties regarding chemical-induced metabolic disruption. We will utilize a battery of New Approach Methodologies (NAMs) including state-of-the-art in vitro and in vivo methods and systems biology approaches, as well as large cohort datasets to provide more comprehensive understanding of the underlying mechanisms of action of metabolic disruptors and their mixtures. The main purpose of this is to find new biomarkers for chemical-induced metabolic disruption for human risk assessment of chemicals. This project has received funding from the European Union's Horizon Europe programme under grant agreement No 101137405. Horizon Europe aims to ensure its citizens’ are living and working in a health-promoting environment.
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www.nemesis-project.eu
NEMESIS Project的外部链接
- 所属行业
- 高等教育
- 规模
- 51-200 人
- 类型
- 教育机构
- 创立
- 2024
动态
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Zebrafish have become a crucial in vivo model in biomedical research, offering valuable insights into human diseases. In October last year, the Emma Wincent Lab at Karolinska Institutet started testing the effects of NEMESIS focus-compounds on adverse outcomes using zebrafish, a non-mammalian model, as part of the in vivo work done in the NEMESIS project. Read more in a blog by Postdoc Oscar Diaz Perez. ?? ????
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NEMESIS has run for just over one year and it was time to see where the project is at. The consortium members met at a General Assembly meeting in Barcelona on 29-30 January 2025 to discuss the progress of the project and the next steps. ?? ?? ?? The meeting was arranged at CSIC Spanish National Research Council – Institute of Environmental Assessment and Water Research (IDAEA-CSIC). #NEMESISproject #HorizonEU
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NEMESIS researchers Henriikka Hakom?ki and Sini Pitk?nen from the University of Eastern Finland made a research visit to the Emma Wincent group at the Karolinska Institutet. The aim of the visit was to explore Wincent's lab and learn new techniques. ?? ???? ?? ???? #NemesisProject #HorizonEU
Back from the holidays! ?? Starting the year strong with a research visit to Karolinska Institutet ???? I am soaking in all bits of information I can gather to make the most of this incredible opportunity. I already have so many great ideas for improvement in the research unit I founded, thanks to the very warm and welcoming staff here at KI! #researchvisit #karolinskainstitutet
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Stay up to date on the progress of the ENKORE projects! Be one of the first ones to subscribe to the ENKORE Cluster newsletter including research results from European research institutions and the NEMESIS project, MERLON research project, ENDOMIX, EDC-MASLD and HYPIEND! ?? ?? https://eepurl.com/i0Iao2 #HorizonEU
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Today, we concluded our first EDC-MASLD Policy Forum, attended by 60+ participants, including experts from the ENKORE Cluster. The forum was a space for exchanging knowledge and aligning science with regulatory needs on endocrine-disrupting chemicals (EDCs).? ? ? Highlights from the Forum:? ? Introduction by Tuulia Hy?tyl?inen (?rebro University) on EDC-MASLD and the ENKORE Cluster.? ? Presentations by Matej Oresic(?rebro University) on bile acids and liver health and Elisabetta Bugianesi and Chiara Rosso (University of Torino) on sexual dimorphism in liver damage.? ? Evidence synthesis used in EDC-MASLD and ENDOMIX by Jorke Kamstra (Utrecht University) and Georg Braun (Helmholtz Centre for Environmental Research (UFZ)) to support risk assessment practices.? ? Ways forward for non-animal methodologies (NAMs) for EDC identification shared by You Song (NIVA) on Adverse Outcome Pathways (AOPs) in EDC-MASLD, Marie Louise Holmer (DTU - Technical University of Denmark) for MERLON research project, and Eva Serrano Candelas (ProtoQSAR) for HYPIEND.? ? Insights from NEMESIS Project on novel biomarkers of exposure by Joan Grimalt (CSIC Barcelona).? ? Thank you to all speakers and participants for your involvement. Your expertise and contributions are crucial for advancing public health policy.? ? ENKORE Cluster HYPIEND ENDOMIX MERLON research project NEMESIS Project ?rebro University #EndocrineDisruptors #EDC #MASLD #NAFLD #PolicyForum #HealthResearch #ScienceAndPolicy #HorizonEurope #RegulatoryScience
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?? Didn’t get a chance to join the 6th Annual Forum on Endocrine Disruptors live? The recording of day 1 is now available! ?? ?? Our ENKORE Cluster session, where we are introduced as the successor to #EURION, starts at 14:45:00 in the video. ? Explore insightful presentations from each ENKORE project - NEMESIS Project, EDC-MASLD, ENDOMIX, HYPIEND, and MERLON research project -focused on advancing research on #EDCs and health impacts. Catch up on this important discussion session ?? https://lnkd.in/eiadczTK European Health and Digital Executive Agency (HaDEA)
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Policy Officer at European Commission (DG ENV, Safe & sustainable chemicals) - Posting in my personal capacity
[3/6] Third session of the 6th Annual Forum on #EndocrineDisruptors was on Research and focusing on ENKORE, the successor of EURION. #EDforum Organized in the European Commission's premises EU Environment and Climate Thanks a lot to our speakers: Alex M., DG RTD, European Commission - Bridging horizons in endocrine disruptors research Prof. Juliette Legler, Utrecht University - The EURION cluster: Highlights of 5 years of ED research ENKORE projects were presented by: 1. NEMESIS project Prof. Susana Viegas, NOVA National School of Public Health - Science to support evidence-based policies on chemical safety 2. EDC-MASLD project Dr. Jorke Kamstra, Utrecht University - Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease 3. ENDOMIX project Dr. Ana Zenclussen - Understanding how endocrine disruptors target the immune system to cause diseases 4. HYPIEND project Dr. Josep M del Bas, Eurecat - Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations 5. MERLON project Dr. Terje Svingen - Enhanced Identification of Endocrine Disruptors Through Integration of Science-Based Regulatory Practices and Innovative Methodologies Live streaming (one link for each day, also available for non-registered attendees, and permanently there for watching the event later): 29 October 2024 - https://lnkd.in/eMqViNiN? 30 October 2024 - https://lnkd.in/emubyvqS Info on the event: https://lnkd.in/dViH-ZK5 Presentations will be uploaded on the webpage of the event (link above) Audiovisual: Videlio-Events Moderation: Tamsin Rose
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?? Exciting update! Today, our #ENKORE cluster is taking part in the 6th Annual Forum on Endocrine Disruptors. ?? Join us this afternoon at 14:15 for a special session where ENKORE will be introduced as the successor to the #EURION cluster. This session will feature presentations from all ENKORE projects: NEMESIS Project, EDC-MASLD, ENDOMIX, HYPIEND and MERLON research project. ?? Don’t miss the opportunity to join the forum online via the following link ?? https://lnkd.in/eiadczTK European Health and Digital Executive Agency (HaDEA)
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