Nautilus Biotechnology

Disease progression is not uniform for every Alzheimer's patient and tau proteoforms may hold the key to understanding why. In 2020, Simon Dujardin and colleagues including Fiona Elwood PhD, Judith Steen, Matthew Kennedy, and Bradley T. Hyman found that Alzheimer's patients have different mixes of tau proteoforms and these mixtures associate with different rates of tau aggregation and cognitive decline. These results suggest a patient’s tau proteoform profile may influence their disease trajectory. Imagine a future where we can: ? Identify the specific tau proteoforms driving pathology in a given patient ? Develop precision therapies that selectively deplete these proteoforms ? Personalize treatment based on a patient’s unique proteoform signature To make this future a reality, we need proteomics technologies that can precisely characterize individual tau proteoforms at scale. That’s why Nautilus Biotechnology is pioneering single-molecule proteomics—to help researchers and drug developers uncover the specific proteoforms driving Alzheimer’s disease. Learn more in our latest blog post: https://lnkd.in/g8gnCEEd #PrecisionMedicine #Alzheimers #TauProteoforms #Proteomics #Proteoforms

Learn how Alzheimer's biomarkers have changed Alzheimer's research and how new blood-based biomarkers can drive the field even further in this clip from Translating Proteomics featuring Sarah DeVos of Curie.Bio. https://lnkd.in/gMVY6Azv #Alzheimers #AlzherimersResearch #TranslatingProteomics #Podcast #Biomarkers

We're #hiring! Join the Nautilus Team as a Senior Product Support Engineer and help us maintain high-quality internal and customer-installed instruments. Learn more on our careers page: https://lnkd.in/gJRkXZi3 #Engineer #Biotech #BiotechJobs #Careers

Scientists are much more than folks in lab coats doing experiments. Our own Chief Scientist Parag Mallick is a professor, co-founder, professional magician, and more. On our most recent episode of #TranslatingProteomics, Parag and "The Proteomics Show" hosts Benjamin Neely and Benjamin Orsburn discuss how every scientist is interesting - a fact that shouldn't be overlooked in #scienceCommunication. https://lnkd.in/gpvPNrUR #Proteomics #Podcast

I'm very proud to work on a team that's excited to take on novel challenges and craft creative solutions. Read my recent "Life at Nautilus" interview to learn how my team and I use our image analysis and software engineering expertise to advance development of the Nautilus Platform with the ultimate goal of making proteomics accessible to any lab! https://lnkd.in/gjhiAXNV #BiotechCareer #BiotechJobs #Biotech #STEM #SoftwareEngineering

Behind every breakthrough in proteomics, there’s a team of innovators pushing boundaries. At Nautilus Biotechnology, Software Engineer Winnie Leung is doing just that—developing cutting-edge image analysis tools to enable us to decode proteins with unprecedented resolution. From capturing videos of beating heart cells in a petri dish to building robust pipelines that process images of billions of single protein molecules, Winnie’s journey in image analysis has been fueled by curiosity, creativity, and collaboration. Her work helps ensure that every image captured on the Nautilus Proteome Analysis Platform contributes to a clearer understanding of the proteome—unlocking insights that could accelerate discoveries in fields like neurodegenerative disease research. Read more about Winnie’s story and her impact at Nautilus: https://lnkd.in/gFJvgW5w #Proteomics #Biotech #Imaging #SoftwareEngineering

#Proteomics moves rapidly and it can be hard to keep up with all the exciting advances. Parag Mallick and Andreas Huhmer share 3 of their favorite examples of proteomics research from 2024 in this episode of Translating Proteomics, and we'd love to hear about some of your favorites! Share them in the comments here or on YouTube and we may cover them in a future episode. https://lnkd.in/gV3iisGM #Biology #Research #UnleashTheProteome #TranslatingProteomics

Interested in learning more about the data we presented at US HUPO 2025? Get access to some of our curated US HUPO 2025 content here: https://lnkd.in/gqZnW685 #USHUPO2025 #Proteomics #Proteoforms #UnleashTheProteome

At US HUPO 2025, we showcased how high-quality proteome measurements on the Nautilus Proteome Analysis Platform are opening new doors for understanding protein function and disease. ?? Key takeaways from our time at the conference: ?? Tau proteoforms & Alzheimer’s models – Our platform measured thousands of tau proteoforms from model systems and for the first time, the human brain. We hope to enable researchers to leverage similar measurements to unravel the role of these proteoforms in neurodegenerative diseases. ?? Broadscale proteomics with confidence – Our PrISM methodology enables single-molecule protein quantification and is designed to deliver high-confidence data at an unprecedented scale. ?? Engaged & enthusiastic conversations – We were thrilled by the curiosity and deep questions from attendees exploring how Nautilus could accelerate their discoveries. ?? Dive into the full recap and explore our latest data here: https://lnkd.in/gZBWxpWC #Proteomics #MassSpectrometry #AlzheimersResearch #Biotech #USHUPO2025 #NautilusBiotechnology #AlzheimersDisease

Do we need Ms Frizzle's help to make the importance of #proteomics clear to the world? https://lnkd.in/gEF6vhqm Parag Mallick, Benjamin Neely, and Benjamin Orsburn discuss many of the communication barriers surrounding proteomics on the latest episode of our Translating Proteomics. How do you think the proteomics can better engage the public imagination? #UnleashTheProteome #Biology #ScienceCommunication #SciComm