National Institute of General Medical Sciences (NIGMS)

#ICYMI: The recording of the 2024 Stetten Lecture is now available. NIGMS grant recipient Dr. Sudha Chakrapani spoke on the “Molecular Mechanisms Underlying Glycinergic Neurotransmission.” Find the link to the full lecture in the comments. Case Western Reserve University #StettenLecture #BiomedicalResearch

Stem cells are unique because they can replicate many times and transform into many specialized types of cells. Two main kinds of stem cells—embryonic and adult—exist in nature, but scientists can create a third type in the laboratory for research. Read our latest Biomedical Beat blog post to learn more about stem cells and how NIGMS-funded scientists are studying them to help unlock the secrets of human biology and treat diseases in the future—link in comments.? #StemCells #StemCellDifferentiation #BasicResearch

Notice of Change to Budget Information for New Investigators in PAR-22-180 “Maximizing Investigators' Research Award (R35 - Clinical Trial Optional).” This notice applies to applications submitted to the January 16, 2025, due date and beyond. For more information, visit the link in the comments.

Notice of Funding Opportunity (NOFO): Advancing Research Careers (ARC) Predoctoral to Postdoctoral Transition Award to Promote Broad Participation (F99/K00 - Clinical Trial Not Allowed). This NOFO supports cohorts of promising, late-stage graduate students from a wide range of backgrounds pursuing research training in NIH mission areas. For more information, visit the link in the comments.

Notice of Funding Opportunity (NOFO): Focused Technology Research and Development (R01 Clinical Trial Not Allowed) (PAR-25-203). This NOFO supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. For more information, visit the link in the comments.

Notice of Funding Opportunity (NOFO): Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed) (PAR-25-202). This NOFO supports exploratory research leading to proof of concept for the development of new technologies relevant to the NIGMS mission. For more information, visit the link in the comments.

Thanks to the National Institutes of Health Office of Extramural Research for having Dr. Alison Gammie, director of the Training and Workforce Development Division at NIGMS, on the NIH All About Grants podcast! Dr. Gammie joined Dr. Lystranne Maynard-Smith, a Scientific Review Officer with the Center for Scientific Review (CSR), to discuss fellowships. In the episode, they share more about how NIH obtained feedback from the research community over several years to help inform the changes to fellowships. They also discuss considerations when putting an application together; approaching the science and training plans; mentoring; resubmissions; and much more. You can listen to the episode via the All About Grants YouTube channel here, or you can listen on Apple Podcasts and Spotify.

Researchers at UC San Diego used the program Cytoscape to visualize a part of the yeast molecular interaction network shown in the image here. The lines in the network represent connections among genes (shown as little dots) and different-colored networks indicate subnetworks—for instance, those in specific locations or pathways in the cell. By following changes in architectures of these networks in response to altered environmental conditions, such as when a cell encounters stress, scientists can further investigate the precise role of these genes to uncover how a cell's molecular machinery deals with stress or other factors. Find this and related images by visiting the link in the comments. #CoolScienceImage #Yeast #BasicResearch #Genetics

It was great meeting everyone who stopped by our booth at Annual Biomedical Research Conference for Minoritized Scientists in Pittsburgh! We hope you enjoyed learning about the variety of training and development programs NIGMS supports. We're looking forward to seeing you again next year in San Antonio, Texas!

In this #CoolScienceImage of the human brain, researchers at UCLA used colors and shapes to show neurological differences between two people. The blurred portion in the front of the brain is associated with complex thought and varies most between the individuals. The blue ovals mark areas of basic function that vary relatively little. Visualizations like this one are part of a project to map complex and dynamic information about the human brain, including genes, enzymes, disease states, and anatomy. It also represents the collaborations between neuroscientists and experts in math, statistics, computer science, bioinformatics, imaging, and nanotechnology. Find this image in the NIGMS gallery using the link in the comments. #Biomedical #BasicScience #HumanBrain