MPN Research Foundation

While leukemia and lymphoma are widely recognized, myelofibrosis (MF) remains one of the most complex and poorly understood blood cancers. That’s why we’re proud to see MF featured in Mediaplanet?Blood Health magazine (?USA TODAY?) putting this rare blood cancer in the spotlight.? In this special feature, we break down how MF compares to other blood cancers.? Don't miss this must-read article on MF’s unique challenges and why research is more critical than ever.?? Read it here:

The March edition of “Under the Microscope” hit your inboxes at 5PM CT today!?? This digest includes:?? ?? Meet Dr. Simon Menedez-Ferrer? ?? Patient Profile: Tyler Parsons?? ?? Q&A with Dr. Mascarenhas? and more!? Join our community today to receive these stories and so much more with this link: https://lnkd.in/gdJNigWV

Dr. Kralovics' dedication has led to groundbreaking discoveries in myeloproliferative neoplasms (#MPNs), including identifying key gene mutations like #JAK2 and #CALR. His current research focuses on harnessing the immune system to target malignant cells, particularly through understanding how mutated calreticulin (mutCALR) escapes immune detection.? Each discovery in Dr. Kralovics' work raises new questions, driving deeper exploration into MPNs. By studying naturally occurring antibodies in MPN patients, his team aims to develop innovative therapies that could improve patient outcomes.? Dive into the full article to learn more about Dr. Kralovics' relentless pursuit of answers in MPN research: https://lnkd.in/gtkShwg3 Join our community of over 30,000 people empowered by research to find answers for these rare blood cancers. https://lnkd.in/g9QknSPR

MPN Research Foundation (MPNRF) recently partnered with Haymarket Medical Education?to develop a #CME-accredited 2-part video webinar series focused on key issues central to #polycythemiavera (PV) diagnosis and treatment.? As part of the project, which is available on the myCME education portal: https://lnkd.in/gbznurUy MPNRF surveyed 250 patients living with PV and nearly 30 clinicians treating the disease to ascertain their respective views on symptom burden, PV’s impact on quality of life, and preferred management strategies.? Two MPN investigators, Drs. Aaron Gerds from Cleveland Clinic and Gabriela Hobbs from Harvard, reviewed data from these surveys during each webinar while also sharing their own perspectives on challenging issues and new research informing the treatment landscape.? Both programs are complimentary and available for AMA, ANCC, and ACPE continuing education credit.

Polycythemia vera & cognitive dysfunction: What do we know?? PV patients often report brain fog, memory issues & difficulty concentrating, yet the underlying mechanisms remain unclear. Is it due to anemia-related hypoxia? Microvascular dysfunction? Chronic inflammation? All of the above?? A new population-based study suggests PV patients face an increased risk of dementia, reinforcing the need to explore inflammatory pathways and cerebrovascular health in MPNs.? One potential explanation is that chronic inflammation and a pro-thrombotic state in PV disrupt normal cerebral blood flow, leading to subtle but significant cognitive effects. Studies in MPN models have shown microvascular stalling in the brain, where capillaries intermittently lose blood flow, which could contribute to symptoms of brain fog. If inflammation and circulation issues are key players, could anti-inflammatory or vascular-targeted treatments help?? More research is needed to develop interventions that preserve cognitive function in PV patients. What are your thoughts on tackling this challenge?? #Hematology #MPNResearch #BrainHealth #PolycythemiaVera? Sources: Sun et al., 2024: https://lnkd.in/gtzZKdvt NCCN MPN Patient Guidelines: https://lnkd.in/gjUfpyDc? Santisakultarm et al., 2014: https://lnkd.in/g8DykMzA

Exciting News! MPN Research Foundation (MPNRF) and Canadian MPN Research Foundation (CMPNRF) are joining forces to accelerate research and improve outcomes for myeloproliferative neoplasm (MPN) patients across the U.S., Canada, and beyond. This collaboration will streamline funding efforts, drive innovation, and maximize impact — while maintaining each organization’s unique connection to its community. Read the full announcement here https://lnkd.in/gpcedFVB Join our community to be the first to know about MPN Research Foundation's upcoming programs and initiatives.

Want to learn more about myeloproliferative neoplasms (MPNs) and empower your journey with the latest research insights? Become a certified MPN Research Foundation Research Advocate! Catch up on the latest MPN Pathways webinars, including our Introduction to MPN Research Foundation & MPNs 101. Follow along today: https://lnkd.in/gukUCFU3

MPN Research Foundation has been called to action by the myeloproliferative neoplasms (MPN) community, including patients, clinicians, and industry stakeholders to further the study of disease progression.? MPN Research Foundation is actively pursuing this goal by building a patient registry that can capture the patient journey and MPN disease progression.? Building an MPN registry is a lofty goal that requires a clear vision to address challenges inherent to this patient population. Download our white paper detailing our background, approach, and vision for building this patient registry with guidance from the experts at @IQVIA. Download here: https://lnkd.in/gwYXD9ec Thank you Sobi - Swedish Orphan Biovitrum AB (publ)? for their support as the first sponsor of this registry. . . . #MPNResearchFoundation #Sobi #IQIVIA #MPNsm #ET #PV #MF #Patientregistry #whitepaper #clinicaltrials

When Jenny was diagnosed with an #MPN, she & Adam turned uncertainty into action — raising $26K for MPN research instead of wedding gifts. Research leads to progress, but we need your help to unlock more answers? Read their story: https://lnkd.in/g6CUT8xN? Donate: https://lnkd.in/gkCYsEkA

Did you know that you can help us fund research for myeloproliferative neoplasms (MPNs)by enjoying your favorite meals? ??? With HungryFriend, 4% of every meal at participating restaurants is donated directly funding groundbreaking research in pursuit of new treatments — and cures — for #ET, #PV, and #MF. Download the app by clicking here: https://lnkd.in/ghqH82_R Start #fundraising on-the-go and get a $5 gift card for signing up!? Want to keep up-to-date on other ways to get involved in the Foundation? Join our community today: https://lnkd.in/eYtrKrca